Now showing items 1-4 of 4

    • Cerebrospinal Fluid Culture Positivity and Clinical Outcomes After Amphotericin-Based Induction Therapy for Cryptococcal Meningitis 

      Rolfes, Melissa A; Rhein, Joshua; Schutz, Charlotte; Taseera, Kabanda; Nabeta, Henry W; Hullsiek, Kathy Huppler; Akampuira, Andrew; Rajasingham, Radha; Musubire, Abdu; Williams, 2Darlisha A; Thienemann, Friedrich; Bohjanen, Paul R; Muzoora, Conrad; Meintjes, Graeme; Meya, David B; Boulware, David R (Infectious Diseases Society of America., 2015-10-19)
      Background. Amphotericin-based combination antifungal therapy reduces mortality from human immunode-fificiency virus (HIV)-associated cryptococcal meningitis. However, 40%–50% of individuals have positive cerebrospinal ...
    • Cerebrospinal Fluid Early Fungicidal Activity as a Surrogate Endpoint for Cryptococcal Meningitis Survival in Clinical Trials 

      Pullen, Matthew F; Hullsiek, Katherine Huppler; Rhein, Joshua; Musubire, Abdu K; Tugume, Lillian; Nuwagira, Edwin; Abassi, Mahsa; Ssebambulidde, Kenneth; Mpoza, Edward; Kiggundu, Ruben; Akampurira, Andrew; Nabeta, Henry W; Schutz, Charlotte; Evans, Emily E; Rajasingham, Radha; Skipper, Caleb P; Pastick, Katelyn A; Williams, Darlisha A; Morawski, Bozena M; Bangdiwala, Ananta S; Meintjes, Graeme; Muzoora, Conrad; Meya, David B; Boulware, David R (Clinical Infectious Diseases, 2020)
      Background: In cryptococcal meningitis phase 2 clinical trials, early fungicidal activity (EFA) of Cryptococcus clearance from cerebrospinal fluid (CSF) is used as a surrogate endpoint for all-cause mortality. The Food and ...
    • The Effect of Therapeutic Lumbar Punctures on Acute Mortality From Cryptococcal Meningitis 

      Rolfes, Melissa A; Huppler Hullsiek, Kathy; Rhein, Joshua; Nabeta, Henry W; Taseera, Kabanda; Schutz, Charlotte; Musubire, Abdu; Rajasingham, Radha; Williams, Darlisha A; Thienemann, Friedrich; Muzoora, Conrad; Meintjes, Graeme; Meya, David B; Boulware, David R (2014)
      Introduction. Cryptococcal meningitis is the most common cause of adult meningitis in sub-Saharan Africa. Raised intracranial pressure (ICP) is common in cryptococcosis. Prior studies suggest elevated ICP is associated with ...
    • Timing of Antiretroviral Therapy after Diagnosis of Cryptococcal Meningitis 

      Boulware, David R; Meya, David B; Muzoora, Conrad; Rolfes, Melissa A; Hullsiek, Huppler Katherine; Musubire, Abdu; Taseera, Kabanda; Nabeta, Henry W; Schutz, Charlotte; Williams, Darlisha A; Rajasingham, Radha; Rhein, Joshua; Thienemann, Friedrich; Lo, Melanie W.; Manabe, Manabe C; Janoff, Edward N; Bohjanen, Paul R; Meintjes, Graeme (2014-06-26)
      Background Cryptococcal meningitis accounts for 20 to 25% of acquired immunodeficiency syndrome–related deaths in Africa. Antiretroviral therapy (ART) is essential for survival; however, the question of when ART should ...