Browsing by Author "Nabeta, Henry W"
Now showing items 1-4 of 4
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Cerebrospinal Fluid Culture Positivity and Clinical Outcomes After Amphotericin-Based Induction Therapy for Cryptococcal Meningitis
Rolfes, Melissa A; Rhein, Joshua; Schutz, Charlotte; Taseera, Kabanda; Nabeta, Henry W; Hullsiek, Kathy Huppler; Akampuira, Andrew; Rajasingham, Radha; Musubire, Abdu; Williams, 2Darlisha A; Thienemann, Friedrich; Bohjanen, Paul R; Muzoora, Conrad; Meintjes, Graeme; Meya, David B; Boulware, David R (Infectious Diseases Society of America., 2015-10-19)Background. Amphotericin-based combination antifungal therapy reduces mortality from human immunode-fificiency virus (HIV)-associated cryptococcal meningitis. However, 40%–50% of individuals have positive cerebrospinal ... -
Cerebrospinal Fluid Early Fungicidal Activity as a Surrogate Endpoint for Cryptococcal Meningitis Survival in Clinical Trials
Pullen, Matthew F; Hullsiek, Katherine Huppler; Rhein, Joshua; Musubire, Abdu K; Tugume, Lillian; Nuwagira, Edwin; Abassi, Mahsa; Ssebambulidde, Kenneth; Mpoza, Edward; Kiggundu, Ruben; Akampurira, Andrew; Nabeta, Henry W; Schutz, Charlotte; Evans, Emily E; Rajasingham, Radha; Skipper, Caleb P; Pastick, Katelyn A; Williams, Darlisha A; Morawski, Bozena M; Bangdiwala, Ananta S; Meintjes, Graeme; Muzoora, Conrad; Meya, David B; Boulware, David R (Clinical Infectious Diseases, 2020)Background: In cryptococcal meningitis phase 2 clinical trials, early fungicidal activity (EFA) of Cryptococcus clearance from cerebrospinal fluid (CSF) is used as a surrogate endpoint for all-cause mortality. The Food and ... -
The Effect of Therapeutic Lumbar Punctures on Acute Mortality From Cryptococcal Meningitis
Rolfes, Melissa A; Huppler Hullsiek, Kathy; Rhein, Joshua; Nabeta, Henry W; Taseera, Kabanda; Schutz, Charlotte; Musubire, Abdu; Rajasingham, Radha; Williams, Darlisha A; Thienemann, Friedrich; Muzoora, Conrad; Meintjes, Graeme; Meya, David B; Boulware, David R (2014)Introduction. Cryptococcal meningitis is the most common cause of adult meningitis in sub-Saharan Africa. Raised intracranial pressure (ICP) is common in cryptococcosis. Prior studies suggest elevated ICP is associated with ... -
Timing of Antiretroviral Therapy after Diagnosis of Cryptococcal Meningitis
Boulware, David R; Meya, David B; Muzoora, Conrad; Rolfes, Melissa A; Hullsiek, Huppler Katherine; Musubire, Abdu; Taseera, Kabanda; Nabeta, Henry W; Schutz, Charlotte; Williams, Darlisha A; Rajasingham, Radha; Rhein, Joshua; Thienemann, Friedrich; Lo, Melanie W.; Manabe, Manabe C; Janoff, Edward N; Bohjanen, Paul R; Meintjes, Graeme (2014-06-26)Background Cryptococcal meningitis accounts for 20 to 25% of acquired immunodeficiency syndrome–related deaths in Africa. Antiretroviral therapy (ART) is essential for survival; however, the question of when ART should ...