Browsing Research Articles by Title
Now showing items 1-20 of 36
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Acute and Sub-acute Toxicity Evaluation in Rats of PPOJ5 and ADOJ6 Herbal Remedies Used Traditionally in the Management of HIV Infection
(European Journal of Medicinal Plants, 2016-09-27)The use of herbal medicine in the treatment of many ailments is on the rise. It’s a common practice in many rural communities where access to health care is poor but also in the developed world. There is however, no much ... -
Acute toxicity, antipyretic and antinociceptive study of the crude saponin from an edible vegetable
(Int. J. Biol. Chem. Sci., 2012)Vernonia amygdalina is commonly used for food and health purposes. Processing of the leaf for food is aimed at removing bitter tasting antinutritional principles like saponins. This study was designed to determine the ... -
ADMET profiling and molecular docking of potential antimicrobial peptides previously isolated from African catfish, Clarias gariepinus
(Frontiers in Molecular Biosciences, 2022)Amidst rising cases of antimicrobial resistance, antimicrobial peptides (AMPs) are regarded as a promising alternative to traditional antibiotics. Even so, poor pharmacokinetic profiles of certain AMPs impede their utility ... -
Antibacterial prescription and the associated factors among outpatients diagnosed with respiratory tract infections in Mbarara Municipality, Uganda
(BMC Pulmonary Medicine, 2021-11-15)Background: Respiratory tract infections (RTI) are the second most frequent diagnosis after Malaria amongst Outpatients in Uganda. Majority are Non pneumonia cough and flu which are self-limiting and often do not require ... -
Antidiabetic Medicinal Plants Used in Democratic Republic of Congo: A Critical Review of Ethnopharmacology and Bioactivity Data
(Frontiers in Pharmacology, 2021-10-27)Several studies have been conducted and published on medicinal plants used to manage Diabetes Mellitus worldwide. It is of great interest to review available studies from a country or a region to resort to similarities/d ... -
Body composition of type 2 diabetes patients in Uganda: A case-control study
(Journal of public health in Africa, 2023)Introduction: The prevalence of obesity among people diagnosed with Type 2 Diabetes Mellitus (T2DM) has been widely documented. However, the specific composition of this bodyweight remains largely unknown. The study aimed ... -
Chemical constituents and evidence-based pharmacological properties of Physalis peruviana L.: An overview
(Journal of Herbmed Pharmacology, 2021)Physalis peruviana L. is among plant species possessing evident nutritional, nutraceutical, and commercial interests. This review highlights the complexity of the chemical composition supporting the multiple pharmacotherapeutic ... -
Chemometric Classification of Mangifera indica L. Leaf Cultivars, Based on Selected Phytochemical Parameters; Implications for Standardization of the Pharmaceutical Raw Materials
(Evidence-Based Complementary and Alternative Medicine, 2023)Introduction: Mangifera indica leaves are among the most common materials employed in manufacturing herbal medicinal products. Despite the phytochemical variation of M. indica cultivars, there are no monographs to guide ... -
Chronic wound isolates and their minimum inhibitory concentrations against third generation cephalosporins at a tertiary hospital in Uganda
(Scientific Reports, 2022)Globally, the burden of chronic wound infections is likely to increase due to the rising levels of bacterial resistance to antibiotics. In the United States of America alone, more than 6.5 million chronicwounds with evidence ... -
Comparison of the Wound Healing Activity of the Leaf and Leaf Ash Extracts of Vernonia amygdalina in Rats
(Research square, 2023)Background: Species in the genus Vernonia (Asteraceae) are traditionally used in the treatment of different ailments, for example, leaves in both fresh and dry forms have been used in dressing wounds. Anecdotal reports ... -
Development and validation of a revised instrument to measure burden of long-term medicines use: the Living with Medicines Questionnaire version 3
(Patient Related Outcome Measures, 2018)Methods: New statements were developed and validated through cognitive interviews with medicine users, and these and a global visual analog scale (VAS) were added to the 42-item LMQ-2. Construct validity was assessed ... -
Differential Effects of Chronic Ethanol Administration and Withdrawal on -Aminobutyric Acid Type A and NMDA Receptor Subunit Proteins in Male and Female Rat Brain
(2004-06)Background: Investigations have shown that chronic ethanol exposure results in selective alterations in levels of -aminobutyric acid (GABA)A and NMDA receptor subunits. We previously reported significant sex differences ... -
Diversity of bacterial community in the rhizosphere and bulk soil of Artemisia annua grown in highlands of Uganda
(Plos one, 2023)High land areas in Uganda are suitable for the farming of Artemisia annua. However, harvested A. annua from these areas contain varying concentrations of antimalarial components. This may be attributed to variation in soil ... -
Effect of Bee Venom and Its Fractions on the Release of Pro-Inflammatory Cytokines in PMA-Differentiated U937 Cells Co-Stimulated with LPS
(Vaccines, 2016-04-19)The venom of Apis mellifera (honey bee) has been reported to play a role in immunotherapy, but existing evidence to support its immuno-modulatory claims is insufficient. Four fractions from whole bee venom (BV) were separated ... -
Effect of Covid-19 in Management of Lung Cancer Disease: A Review
(Asian Journal of Pharmaceutical Research and Development, 2022)COVID-19 outcomes may be more severe in lung cancer patients. As a COVID-19 pandemic spreads, it's critical to identify which people and malignancies are most susceptible. COVID-19 appears to have the worst results in lung ... -
Evaluation of antibiotic use among inpatients in surgical ward at Mbarara Regional Referral Hospital, South-Western Uganda
(Infectious Diseases Research, 2023)Objective: The main aim of this study was to evaluate antibiotic use among inpatients in surgical ward at South-Mbarara Regional Referral Hospital, South-Western Uganda. Methodology: A retrospective cross-sectional study ... -
High PrEP uptake and objective longitudinal adherence among HIV-exposed women with personal or partner plans for pregnancy in rural Uganda: A cohort study
(PLoS Medicine, 2023)Background: In Uganda, fertility rates and adult HIV prevalence are high, and many women conceive with partners living with HIV. Pre-exposure prophylaxis (PrEP) reduces HIV acquisition for women and, therefore, infants. ... -
The Impact on Public Health and Economy Using Lockdown as a Tool against COVID-19 Pandemic in Africa: A Perspective
(Journal of Epidemiology and Public Health Reviews, 2020)Background: Since the spread of Corona Virus Disease 19 (COVID-19) most African countries have embarked on a system of either total or partial lockdown and have used it as a tool for curbing the spread of COVID-19. This ... -
An LCMS method for the assay of melittin in cosmetic formulations containing bee venom
(Analytical and Bioanalytical Chemistry, 2015)There is a growing interest in the potential of bee venom in cosmetics as a rejuvenating agent. Products currently on the market do not specify exactly their content of bee venom (BV). Therefore, we developed a method for ... -
Metabolomic Profiling of the Effects of Melittin on Cisplatin Resistant and Cisplatin Sensitive Ovarian Cancer Cells Using Mass Spectrometry and Biolog Microarray Technology
(Metabolites, 2017)In the present study, liquid chromatography-mass spectrometry (LC-MS) was employed to characterise the metabolic profiles of two human ovarian cancer cell lines A2780 (cisplatin-sensitive) and A2780CR (cisplatin-resistant) ...