dc.contributor.author | Kasali, Félicien Mushagalusa | |
dc.contributor.author | Ali, Muhammad Shaiq | |
dc.contributor.author | Kadima, Justin Ntokamunda | |
dc.contributor.author | Tusiimire, Jonans | |
dc.contributor.author | Lateef, Mehreen | |
dc.contributor.author | Omole, Ruth Anyango | |
dc.contributor.author | Tabakam, Gaétan Tchangou | |
dc.contributor.author | Agaba, Amon Ganafa | |
dc.date.accessioned | 2023-10-13T09:13:02Z | |
dc.date.available | 2023-10-13T09:13:02Z | |
dc.date.issued | 2023 | |
dc.identifier.citation | Kasali, F. M., Ali, M. S., Kadima, J. N., Tusiimire, J., Lateef, M., Omole, R. A., ... & Agaba, A. G. (2023), GC-FID and GC-MS profiling and in vitro antidiabetic and antioxidant activities of Chenopodium ambrosioides L.;Natural Resources for Human Health. | en_US |
dc.identifier.uri | http://ir.must.ac.ug/xmlui/handle/123456789/3169 | |
dc.description.abstract | Chenopodium ambrosioides is widely used in traditional medicines to manage several health conditions. This study aimed to investigate the chemical composition of the n-hexane fraction and the in vitro antidiabetic and antioxidant properties of C. ambrosioides L. The chemical composition was determined using Gas Chromatography-Flame Ionization Detection and Gas Chromatography-Mass Spectrometry. In vitro evaluations were assessed by evaluating the inhibitory potentials on the activities of _-glucosidase and antioxidant. A total of 58 phytochemicals were identified belonging to 11 classes of substances, of which aliphatic hydrocarbons (38.25%), diterpenes (20.54%), esters (16.33%), triterpenes (11.91%), diverse functional groups (3.74%), aromatic hydrocarbons (2.64%), sesquiterpenes (2.31%), alcohols (1.41%), ketones (0.29%), monoterpenes (0.16%), and fatty acids (0.14%). The major compounds were heptacosane (30.48%) (46), phytol (20.94) (35), and squalene (11.07%) (56). The methanol extract and its fractions showed moderate _-glucosidase activity, but their IC50 values were lower than the positive control 1-deoxynojirimycin. However, the methanol and methanol-water fractions exhibited more scavenging activity on 2,2-diphenyl-1-picrylhydrazyl with IC50 values similar to butylated hydroxyanisole (BHA). The plant is rich in various phytoconstituents, and it’s _-glucosidase and antioxidant status may justify its use in traditional medicine, especially for preventing complications of diabetes. | en_US |
dc.description.sponsorship | PHARMBIOTRAC | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | Natural Resources for Human Health. | en_US |
dc.subject | Antidiabetic activity | en_US |
dc.subject | Antioxidant inhibition | en_US |
dc.subject | Chenopodium ambrosioides | en_US |
dc.subject | GC-FID | en_US |
dc.subject | GC-MS | en_US |
dc.title | GC-FID and GC-MS profiling and in vitro antidiabetic and antioxidant activities of Chenopodium ambrosioides L. | en_US |
dc.type | Article | en_US |