Now showing items 1-14 of 14

    • Cerebrospinal Fluid Early Fungicidal Activity as a Surrogate Endpoint for Cryptococcal Meningitis Survival in Clinical Trials 

      Pullen, Matthew F; Hullsiek, Katherine Huppler; Rhein, Joshua; Musubire, Abdu K; Tugume, Lillian; Nuwagira, Edwin; Abassi, Mahsa; Ssebambulidde, Kenneth; Mpoza, Edward; Kiggundu, Ruben; Akampurira, Andrew; Nabeta, Henry W; Schutz, Charlotte; Evans, Emily E; Rajasingham, Radha; Skipper, Caleb P; Pastick, Katelyn A; Williams, Darlisha A; Morawski, Bozena M; Bangdiwala, Ananta S; Meintjes, Graeme; Muzoora, Conrad; Meya, David B; Boulware, David R (Clinical Infectious Diseases, 2020)
      Background: In cryptococcal meningitis phase 2 clinical trials, early fungicidal activity (EFA) of Cryptococcus clearance from cerebrospinal fluid (CSF) is used as a surrogate endpoint for all-cause mortality. The Food and ...
    • Cerebrospinal Fluid Lactate as a Prognostic Marker of Disease Severity and Mortality in Cryptococcal Meningitis 

      Abassi, Mahsa; Bangdiwala, Ananta S.; Nuwagira, Edwin; Tadeo, Kiiza Kandole; Okirwoth, Michael; Williams, Darlisha A.; Mpoza, Edward; Tugume, Lillian; Ssebambulidde, Kenneth; Hullsiek, Kathy Huppler; Musubire, Abdu K.; Muzoora, Conrad; Rhein, Joshua; Meya, David B.; Boulware, David R. (Clinical Infectious Diseases, 2021)
      Background: Cerebrospinal fluid (CSF) lactate levels can be used to differentiate between bacterial and viral meningitis. We measured CSF lactate in individuals with cryptococcal meningitis to determine its clinical ...
    • Detrimental Outcomes of Unmasking Cryptococcal Meningitis With Recent ART Initiation 

      Rhein, Joshua; Hullsiek, Kathy H.; Evans, Emily E.; Tugume, Lillian; Nuwagira, Edwin; Ssebambulidde, Kenneth; Kiggundu, Reuben; Mpoza, Edward; Musubire, Abdu K.; Bangdiwala, Ananta S.; Bahr, Nathan C.; Williams, Darlisha A.; Abassi, Mahsa; Muzoora, Conrad; Meya, David B.; Boulware, David R. (In Open forum infectious diseases, 2018)
      Background: Increased antiretroviral therapy (ART) availability has been associated with more patients developing cryptococcosis after ART initiation. Despite this changing epidemiology, data regarding cryptococcal meningitis ...
    • Differences in Immunologic Factors Among Patients Presenting with Altered Mental Status During Cryptococcal Meningitis 

      Lofgren, Sarah; Hullsiek, Kathy H.; Morawski, Bozena M.; Nabeta, Henry W.; Kiggundu, Reuben; Taseera, Kabanda; Musubire, Abdu; Schutz, Charlotte; Abassi, Mahsa; Bahr, Nathan C.; Tugume, Lillian; Muzoora, Conrad; Williams, Darlisha A.; Rolfes, Melissa A.; Velamakanni, Sruti S.; Rajasingham, Radha; Meintjes, Graeme; Rhein, Joshua; Meya, David B.; Boulware, David R. (The Journal of Infectious Diseases, 2017-01)
      Altered mental status in cryptococcal meningitis results in poorer survival, but underlying causes of altered mentation are poorly understood. Within two clinical trials, we assessed risk factors for altered mental status ...
    • The effect of sertraline on depression and associations with persistent depression in survivors of HIV-related cryptococcal meningitis 

      Lofgren, Sarah M.; Velamakanni, Sruti S.; Hullsiek, Katherine Huppler; Bangdiwala, Ananta S.; Namudde, Alice; Musubire, Abdu K.; Mpoza, Edward; Abassi, Mahsa; . Pastick, Katelyn A; Nuwagira, Edwin; Evans, Emily E.; Rajsasingham, Radha; . Williams, Darlisha A; Muzoora, Conrad; Creswell, Fiona V.; Rhein, Joshua; Bond, David J.; Nakasujja, Noeline; Meya, David B.; Boulware, David R. (Wellcome Open Research, 2021)
      Background: Depression is a risk factor for worse outcomes in persons living with HIV/AIDS and has a prevalence more than three times as high as in the general population. Despite this, there are few randomized studies of ...
    • Evaluation of a point-of-care immunoassay test kit `StrongStep' for cryptococcal antigen detection 

      Mpoza, Edward; Mukaremera, Liliane; Kundura, Didas Atwebembere; Akampurira, Andrew; Luggya, Tonny; Tadeo, Kiiza Kandole; Pastick, Katelyn A.; Bridge, Sarah C.; Tugume, Lillian; Kiggundu, Reuben; Musubire, Abdu K.; Williams, Darlisha A.; Muzoora, Conrad; Nalintya, Elizabeth; Rajasingham, Radha; Rhein, Joshua; Boulware, David R.; Meya, David B.; Abassi, Mahsa (PLoS One, 2018)
      Background: HIV-associated cryptococcal meningitis is the leading cause of adult meningitis in Sub- Saharan Africa, accounting for 15%±20% of AIDS-attributable mortality. The development of point-of-care assays has greatly ...
    • High Mortality Associated with Unmasking Cryptococcal Meningitis 

      Rhein, Joshua; Hullsiek, Kathy Huppler; Bahr, Nathan C; Tugume, Lillian; Nuwagira, Edwin; Ssebambulidde, Kenneth; Kiggundu, Reuben; Evans, Emily E; Mpoza, Edward; Williams, Darlisha A; Abassi, Mahsa; Musubire, Abdu; Muzoora, Conrad; Meya, David B; Boulware, David R (Boston, 2018)
      Introduction: Increased antiretroviral therapy (ART) availability in Africa has led to more patients developing cryptococcosis after ART initiation. Despite this changing epidemiology, data regarding cryptococcal meningitis ...
    • HIV-Associated Cryptococcal Meningitis Occurring at Relatively Higher CD4 Counts 

      Tugume, Lillian; Rhein, Joshua; Hullsiek, Kathy Huppler; Mpoza, Edward; Kiggundu, Reuben; Ssebambulidde, Kenneth; Schutz, Charlotte; Taseera, Kabanda; Williams, Darlisha A.; Abassi, Mahsa; Muzoora, Conrad; Musubire, Abdu K.; Meintjes, Graeme; Meya, David B.; Boulware, David R.; On behalf of COAT and ASTRO-CM teams (The Journal of infectious diseases, 2019)
      Background: Cryptococcal meningitis can occur in persons with less-apparent immunosuppression. We evaluated clinical characteristics and outcomes of persons with HIV-related Cryptococcus presenting with higher CD4 ...
    • HIV-Associated Cryptococcal Meningitis Occurring at Relatively Higher CD4 Counts 

      Tugume, Lillian; Rhein, Joshua; Hullsiek, Kathy Huppler; Mpoza, Edward; Kiggundu, Reuben; Ssebambulidde, Kenneth; Schutz, Charlotte; Taseera, Kabanda; Williams, Darlisha A.; Abassi, Mahsa; Muzoora, Conrad; Musubire, Abdu K.; Meintjes, Graeme; Meya, David B.; Boulware, David R. (The Journal of infectious diseases, 2019)
      Background. Cryptococcal meningitis can occur in persons with less-apparent immunosuppression. We evaluated clinical characteristics and outcomes of persons with HIV-related Cryptococcus presenting with higher CD4 ...
    • Outpatient Cryptococcal Antigen Screening Is Associated With Favorable Baseline Characteristics and Improved Survival in Persons With Cryptococcal Meningitis in Uganda 

      Levin, Anna E.; Bangdiwala, Ananta S.; Nalintya, Elizabeth; Kagimu, Enock; Kasibante, John; Rutakingirwa, Morris K.; Mpoza, Edward; Jjunju, Samuel; Nuwagira, Edwin; Naluyima, Rose; Kirumira, Paul; Hou, Cody; Ssebambulidde, Kenneth; Musubire, Abdu K.; Williams, Darlisha A.; Abassi, Mahsa; Muzoora, Conrad; Hullsiek, Katherine H.; Rajasingham, Radha; Meya, David B.; Boulware, David R.; Skipper, Caleb P. (Clinical Infectious Diseases, 2023)
      Background: It is unknown whether persons with symptomatic cryptococcal meningitis detected during routine blood cryptococcal antigen (CrAg) screening have better survival than persons presenting with overt meningitis. ...
    • A secondary analysis of depression outcomes from a randomized controlled trial of adjunctive sertraline for HIV associated cryptococcal meningitis 

      Lofgren, Sarah M.; Velamakanni, Sruti S.; Hullsiek, Katherine Huppler; Bangdiwala, Ananta S.; Namudde, Alice; Musubire, Abdu K.; Mpoza, Edward; Abassi, Mahsa; Pastick, Katelyn A.; Nuwagira, Edwin; Evans, Emily E.; Rajsasingham, Radha; Williams, Darlisha A.; Muzoora, Conrad; Creswell, Fiona V.; Rhein, Joshua; Bond, David J.; Nakasujja, Noeline; Meya, David B.; Boulware, David R. (Wellcome Open Research, 2022)
      Background: Depression is a risk factor for worse HIV outcomes in persons living with HIV/AIDS, including engagement-in-care, HIV medication adherence, and retention-in-care. Depression has a prevalence of more than three ...
    • Seizures in HIV-associated Cryptococcal Meningitis: Predictors and Outcomes 

      Pastick, Katelyn A; Bangdiwala, Ananta S; Abassi, Mahsa; Flynn, Andrew G; Morawski, Bozena M; Musubire, Abdu K; Eneh, Prosperity C; Schutz, Charlotte; Taseera, Kabanda; Rhein, Joshua; Hullsiek, Kathy Huppler; Nicol, Melanie R; Vidal, Jose E; Nakasujja, Noeline; Meintjes, Graeme; Muzoora, Conrad; Meya, David B; Boulware, David R (In Open Forum Infectious Diseases, 2019)
      Background: Seizures commonly occur in patients with cryptococcal meningitis, yet risk factors and outcomes related to seizures are not well described. Methods: We performed post-hoc analyses on participants prospectively ...
    • Symptomatic Cryptococcal Antigenemia Presenting as Early Cryptococcal Meningitis With Negative Cerebral Spinal Fluid Analysis 

      Ssebambulidde, Kenneth; Bangdiwala, Ananta S.; Kwizera, Richard; Kandole, Tadeo Kiiza; Tugume, Lillian; Kiggundu, Reuben; Mpoza, Edward; Nuwagira, Edwin; Williams, Darlisha A.; Lofgren, Sarah M.; Abassi, Mahsa; Musubire, Abdu K.; Cresswell, Fiona V.; Rhein, Joshua; Muzoora, Conrad; Hullsiek, Kathy Huppler; Boulware, David R.; Meya, David B. (Clinical Infectious Diseases, 2019)
      Background: Individuals with cryptococcal antigenemia are at high risk of developing cryptococcal meningitis if untreated. The progression and timing from asymptomatic infection to cryptococcal meningitis is unclear. We ...
    • Therapeutic lumbar punctures in HIV-associated cryptococcal meningitis: should opening 3 pressure direct management 

      Kagimu, Enock; Engen, Nicole; Ssebambulidde, Kenneth; Kasibante, John; Kiiza, Tadeo K; Mpoza, Edward; L, Lillian Tugume; Nuwagira, Edwin; Nsangi, Laura; Williams, Darlisha A; Hullsiek, Kathy Huppler; Boulware, David R; Meya, David B; Rhein, Joshua; Abassi, Mahsa; Musubire, Abdu K (In Open Forum Infectious Diseases, 2022)
      Background: Increased intracranial pressure (ICP) frequently complicates cryptococcal meningitis. Therapeutic lumbar punctures (LPs) have acute survival benefits in the first week, 4and we sought to understand the longer-term ...