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Cytomegalovirus Infections in Ugandan Infants: Newborns, Neonates with Sepsis and Infants with Hydrocephalus
(2019)
Background: Congenital and postnatal cytomegalovirus (CMV) infections in Uganda is prevalent and may compromise the health of Ugandan children. The objective of this study is to
estimate the prevalence of CMV infections ...
Incidence of postpartum infection, outcomes and associated risk factors at Mbarara regional referral hospital in Uganda
(BMC pregnancy and childbirth, 2018)
Background: There is a paucity of recent prospective data on the incidence of postpartum infections and associated risk factors in sub-Saharan Africa. Retrospective studies estimate that puerperal sepsis causes approximately ...
Antimicrobial-resistant infections among postpartum women at a Ugandan referral hospital
(PLOS ONE, 2017)
Puerperal sepsis causes 10% of maternal deaths in Africa, but prospective studies on incidence, microbiology and antimicrobial resistance are lacking.
Methods
We performed a prospective cohort study of 4,231 Ugandan women ...
Vaginal microbiome topic modeling of laboring Ugandan women with and without fever
(Biofilms and Microbiomes, 2020)
The composition of the maternal vaginal microbiome influences the duration of pregnancy, onset of labor, and even neonatal outcomes. Maternal microbiome research in sub-Saharan Africa has focused on non-pregnant and ...
Risk Factors for Vaginal Colonization and Relationship between Bacterial Vaginal Colonization and In-Hospital Outcomes in Women with Obstructed Labor in a Ugandan Regional Referral Hospital
(International Journal of Microbiology, 2018)
Introduction. (e proportion of women with severe maternal morbidity from obstructed labor is between 2 and 12% in resource-limited settings. Maternal vaginal colonization with group B streptococcus (GBS), Escherichia coli, ...
Wireless versus routine physiologic monitoring after cesarean delivery to reduce maternal morbidity and mortality in a resource-limited setting: protocol of type 2 hybrid effectiveness-implementation study
(BMC pregnancy and childbirth, 2021)
Background: Women in sub-Saharan Africa have the highest rates of morbidity and mortality during childbirth globally. Despite increases in facility-based childbirth, gaps in quality of care at facilities have limited ...
Placental Decidual Arteriopathy and Vascular Endothelial Growth Factor A Expression Among Women With or Without Human Immunodeficiency Virus
(The Journal of Infectious Diseases, 2021)
Background. Women with human immunodeficiency virus (HIV) (WHIV) are at higher risk of adverse birth outcomes. Proposed mechanisms for the increased risk include placental arteriopathy (vasculopathy) and maternal vascular ...
Altered Maternal Antibody Profiles in Women With Human Immunodeficiency Virus Drive Changes in Transplacental Antibody Transfer
(Clinical Infectious Diseases, 2022)
Background: Human immunodeficiency virus (HIV)–exposed, uninfected (HEU) children have a higher risk of severe infection, but the causes are poorly understood. Emerging data point to altered antibody transfer in women with ...
Placental decidual arteriopathy and vascular endothelial growth factor A (VEGF-A) expression among women with and without HIV
(The Journal of Infectious Diseases, 2021)
Background: Women with HIV (WHIV) are at higher risk of adverse birth outcomes. Proposed mechanisms for the increased risk include placental arteriopathy (vasculopathy) and maternal vascular malperfusion (MVM) due to ...
Chronic Placental Inflammation Among Women Living With HIV in Uganda
(ournal of Acquired Immune Deficiency Syndromes, 2020)
Background: HIV-exposed, uninfected (HEU) children have poorer early-life outcomes than HIV-unexposed children. The determinants of adverse health outcomes among HEU children are poorly understood but may result from chronic ...