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Improving the Specificity of Plasmodium falciparum Malaria Diagnosis in High- Transmission Settings with a Two-Step Rapid Diagnostic Test and Microscopy Algorithm
(Journal of Clinical Microbiology, 2017)
Poor specificity may negatively impact rapid diagnostic test (RDT)-based diagnostic strategies for malaria. We performed real-time PCR on a subset of subjects who had undergone diagnostic testing with a multiple-antigen ...
A novel CRISPR-based malaria diagnostic capable of Plasmodium detection, species differentiation, and drug-resistance genotyping
(BioMedicine, 2021)
Background: CRISPR-based diagnostics are a new class of highly sensitive and specific assays with multiple applications in infectious disease diagnosis. SHERLOCK, or Specific High-Sensitivity Enzymatic Reporter UnLOCKing, ...
Comparison of Capillary Versus Venous Blood for the Diagnosis of Plasmodium falciparum Malaria Using Rapid Diagnostic Tests
(The Journal of infectious diseases, 2021)
We enrolled 250 febrile children in western Uganda to compare the results of malaria rapid diagnostic tests (RDTs) when using capillary vs venous blood. Participants were tested with 4 different RDT types. Polymerase chain ...
Reuse of malaria rapid diagnostic tests for amplicon deep sequencing to estimate Plasmodium falciparum transmission intensity in western Uganda
(Scientific reports, 2018)
Molecular techniques are not routinely employed for malaria surveillance, while cross-sectional,
community-based parasite surveys require significant resources. Here, we describe a novel use of
malaria rapid diagnostic ...
Permethrin‑treated baby wraps for the prevention of malaria: results of a randomized controlled pilot study in rural Uganda
(Malaria Journal, 2022)
Background: Progress against malaria has stalled and may even be slipping backwards in high-burden countries. This is due to a range of factors including insecticide resistance and mosquito feeding behaviours that limit ...