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Now showing items 1-10 of 11
High Mobility Group Box 1 (HMGB1) and HIV-Associated Kaposi’s Sarcoma in Africa
(Academia.edu, 2015)
Other than Kaposi’s sarcoma-associated herpesvirus (KSHV) and CD4+ T cell lymphopenia, the mechanisms responsible for KS are poorly understood. Additional mechanisms must exist in sub-Saharan Africa given that only a ...
A Causal Framework for Understanding the Effect of Losses to Follow-up on Epidemiologic Analyses in Clinic-based Cohorts: The Case of HIV-infected Patients on Antiretroviral Therapy in Africa
(American journal of epidemiology, 2012)
Although clinic-based cohorts are most representative of the ‘‘real world,’’ they are susceptible to loss to follow-up. Strategies for managing the impact of loss to follow-up are therefore needed to maximize the value of ...
D-dimer levels and traditional risk factors are associated with incident hypertension among HIV-infected individuals initiating antiretroviral therapy in Uganda
(Journal of acquired immune deficiency syndromes, 2016)
Objectives-We sought to describe blood pressure changes after antiretroviral therapy (ART) initiation and evaluate the association of markers of inflammation with incident hypertension in a cohort of HIV-individuals in ...
Self-reported alcohol abstinence associated with ART initiation among HIV-infected persons in rural Uganda
(Drug and alcohol dependence, 2014)
BACKGROUND—There is limited data on the impact of anti-retroviral treatment (ART) initiation on alcohol consumption. We characterized predictors of abstaining from alcohol among
HIV-infected individuals following ART ...
Incidence of postpartum infection, outcomes and associated risk factors at Mbarara regional referral hospital in Uganda
(BMC pregnancy and childbirth, 2018)
Background: There is a paucity of recent prospective data on the incidence of postpartum infections and associated risk factors in sub-Saharan Africa. Retrospective studies estimate that puerperal sepsis causes approximately ...
HIV Infection and risk of postpartum infection, complications and mortality in rural Uganda
(AIDS Care, 2018)
HIV infection may increase risk of postpartum infection and infection-related mortality. We hypothesized that postpartum infection incidence and attributable mortality in Mbarara, Uganda would be higher in HIV-infected ...
Optimizing Network Connectivity for Mobile Health Technologies in sub-Saharan Africa
(PLoS ONE, 2012)
Background: Mobile health (mHealth) technologies hold incredible promise to improve healthcare delivery in resource limited settings. Network reliability across large catchment areas can be a major challenge. We performed ...
Non-R5-tropic HIV-1 in Subtype A1 and D Infections Were Associated with Lower Pre-therapy CD4 Count But Not with PI/(N)NRTI Therapy Outcomes in Mbarara, Uganda
(AIDS, 2016)
Background: Previous studies suggest that infection with non-R5-tropic subtype B HIV-1, compared to R5, is associated with a more rapid decline in CD4 count, but does not affect PI/(N)NRTI therapy outcome. Here, we explored ...
Prevalence and Clinical Impacts of HIV-1 Intersubtype Recombinants in Uganda Revealed by Near-Full-Genome Population and Deep Sequencing Approaches
(Lee, G. Q., Bangsberg, D. R., Mo, T., Lachowski, C., Brumme, C. J., Zhang, W., ... & Harrigan, P. R. (2017). Prevalence and clinical impacts of HIV-1 intersubtype recombinants in Uganda revealed by near-full-genome population and deep sequencing approaches. AIDS (London, England), 31(17), 2345., 2017)
Objectives: To estimate prevalence, examine time trends, and test for clinical correlates and outcomes associated with HIV-1 intersubtype recombination under a full-genome sequencing context in a rural community in Mbarara, ...
Tracking a sample of patients lost to follow-up has a major impact on understanding determinants of survival in HIV-infected patients on antiretroviral therapy in Africa
(Tropical Medicine & International Health, 2010)
Objective: To date, data regarding the determinants of mortality in HIV-infected patients starting antiretroviral therapy (ART) in Africa have been primarily derived from routine clinical care settings practicing the public ...