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Timing of Antiretroviral Therapy and Systemic Inflammation in Sub-Saharan Africa: Results From the META Longitudinal Cohort Study
(The Journal of infectious diseases, 2019)
Chronic inflammation predicts complications in persons with human immunodeficiency virus infection. We compared D-dimer, soluble CD14, and interleukin 6 levels before and 12 months after antiretroviral therapy (ART) ...
Inflammatory biomarkers prior to antiretroviral therapy as prognostic markers of 12-month mortality in South Africa and Uganda
(AIDS, 2019)
Objective: The aim of this study was to determine the utility of biomarkers of immune activation, systemic inflammation and coagulopathy prior to antiretroviral therapy to predict mortality during the first year of ...
D-dimer levels and traditional risk factors are associated with incident hypertension among HIV-infected individuals initiating antiretroviral therapy in Uganda
(Journal of acquired immune deficiency syndromes, 2016)
Objectives-We sought to describe blood pressure changes after antiretroviral therapy (ART) initiation and evaluate the association of markers of inflammation with incident hypertension in a cohort of HIV-individuals in ...
GPS-measured distance to clinic, but not self-reported transportation factors, are associated with missed HIV clinic visits in rural Uganda
(AIDS, 2013)
Objective—Studies of the association between transportation barriers and HIV-related health
outcomes have shown both positive and negative effects, possibly because a reliable, validated
measure of transportation barriers ...
Disinhibition in Risky Sexual Behavior in Men, but Not Women, during Four Years of Antiretroviral Therapy in Rural, Southwestern Uganda
(PLoS ONE, 2013-07-19)
Background: In resource-rich areas, risky sexual behavior (RSB) largely diminishes after initiation of anti-retroviral therapy, with notable exceptions among some populations who perceive a protected benefit from anti-retroviral ...
Rethinking the ‘‘Pre’’ in Pre-Therapy Counseling: No Benefit of Additional Visits Prior to Therapy on Adherence or Viremia in Ugandans Initiating ARVs
(PLoS One, 2012)
Background: Many guidelines recommend adherence counseling prior to initiating antiretrovirals (ARVs), however the additional benefit of pre-therapy counseling visits on early adherence is not known. We sought to assess ...
The Technology Acceptance Model for Resource-Limited Settings (TAM-RLS): A Novel Framework for Mobile Health Interventions Targeted to Low-Literacy End-Users in Resource-Limited Settings
(AIDS and Behavior, 2017)
Although mobile health (mHealth) technologies have shown promise in improving clinical care in resource limited settings (RLS), they are infrequently brought to scale. One limitation to the success of many mHealth interventions ...
A combination SMS and transportation reimbursement intervention to improve HIV care following abnormal CD4 test results in rural Uganda: a prospective observational cohort study
(BMC medicine, 2015)
Background: Up to 50 % of HIV-infected persons in sub-Saharan Africa are lost from care between HIV diagnosis and antiretroviral therapy (ART) initiation. Structural barriers, including cost of transportation to clinic and ...
Depression and suicidal ideation among HIV-infected adults receiving efavirenz versus nevirapine in Uganda: a prospective cohort study
(Annals of internal medicine, 2018)
Background: There is conflicting evidence about potential adverse neuropsychiatric effects of efavirenz and limited data from sub-Saharan Africa, where efavirenz is used as first-line therapy and 70% of people living with ...
Antiretroviral Therapy Adherence Interruptions are Associated with Systemic Inflammation among Ugandans who Achieved Viral Suppression
(Journal of acquired immune deficiency syndromes, 2019)
Background: Residual systemic inflammation, which is associated with non-AIDS clinical outcomes, may persist despite viral suppression. We assessed the effect of antiretroviral (ART) adherence interruptions on systemic ...