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Improving the Specificity of Plasmodium falciparum Malaria Diagnosis in High- Transmission Settings with a Two-Step Rapid Diagnostic Test and Microscopy Algorithm
(Journal of Clinical Microbiology, 2017)
Poor specificity may negatively impact rapid diagnostic test (RDT)-based diagnostic strategies for malaria. We performed real-time PCR on a subset of subjects who had undergone diagnostic testing with a multiple-antigen ...
Reuse of malaria rapid diagnostic tests for amplicon deep sequencing to estimate Plasmodium falciparum transmission intensity in western Uganda
(Scientific reports, 2018)
Molecular techniques are not routinely employed for malaria surveillance, while cross-sectional,
community-based parasite surveys require significant resources. Here, we describe a novel use of
malaria rapid diagnostic ...
Malaria Prevalence and Associated Factors in Children Under Five Years in Dokolo District, Northern Uganda: A Community-Based Cross-Sectional Study
(Annals of Epidemiology and Public Health, 2023)
Introduction: Malaria remains a major public health problem affecting children <5 years because of the weak im¬mune system. Uganda set targets to control and eliminate malaria with interventions of most at-risk groups; ...
Supervised versus unsupervised intake of sixdose artemether-lumefantrine for treatment of acute, uncomplicated Plasmodium falciparum malaria in Mbarara, Uganda: a randomised trial.
(Lancet, 2005)
Background: The six-dose regimen of artemether-lumefantrine is effective and is among combination therapies prioritised to replace antimalarials that no longer work in Africa. However, its effectiveness has not been assessed ...
Limited threat of Plasmodium falciparum pfhrp2 and pfhrp3 gene deletion to the utility of HRP2-based malaria RDTs in Northern Uganda
(Malaria Journal, 2024)
Background: Rapid diagnostic tests (RDTs) that detect Plasmodium falciparum histidine-rich protein-2 (PfHRP2) are exclusively deployed in Uganda, but deletion of the pfhrp2/3 target gene threatens their usefulness as malaria ...