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Association of Hyponatremia on Mortality in Cryptococcal Meningitis: A Prospective Cohort
(Open Forum Infectious Diseases, 2022-06-17)
Background: Sodium abnormalities are frequent in central nervous system infections and may be caused by cerebral salt wasting, syndrome of inappropriate antidiuretic hormone secretion, or medication adverse events. In ...
Causal impact of malnutrition on mortality among adults hospitalized for medical illness in sub-Saharan Africa: what is the role of severe sepsis?
(BMC Nutrition, 2015)
Background: In sub-Saharan Africa, malnutrition is associated with mortality in adults hospitalized for medical illness. However, it remains unclear whether this association is causal, and if causal, what the potential ...
Impact of CD8+ T Cell Activation on CD4+ T Cell Recovery and Mortality in HIV-infected Ugandans Initiating Antiretroviral Therapy
(AIDS, 2011)
Objectives—To assess whether T cell activation independently predicts the extent of CD4+ T
cell recovery and mortality in HIV-infected Ugandans initiating antiretroviral therapy (ART).
Design—Prospective cohort ...
The Effect of Therapeutic Lumbar Punctures on Acute Mortality From Cryptococcal Meningitis
(Clinical infectious diseases, 2014-07-23)
Introduction. Cryptococcal meningitis is the most common cause of adult meningitis in sub-Saharan Africa. Raised intracranial pressure (ICP) is common in cryptococcosis. Prior studies suggest elevated ICP is associated ...
Blood neutrophil counts in HIV-infected patients with cryptococcal meningitis: Association with mortality
(PLoS ONE, 2018)
Background: The mortality from cryptococcal meningitis remains high, despite the availability of antiretroviral therapy (ART) and amphotericin-based fungal regimens. The role of neutrophils in cryptococcosis is controversial. ...
Cerebrospinal Fluid Lactate as a Prognostic Marker of Disease Severity and Mortality in Cryptococcal Meningitis
(Clinical Infectious Diseases, 2021)
Background: Cerebrospinal fluid (CSF) lactate levels can be used to differentiate between bacterial and viral meningitis. We measured CSF lactate in individuals with cryptococcal meningitis to determine its clinical ...
HIV-infected women on antiretroviral treatment in Uganda have increased mortality during pregnant and postpartum periods
(AIDS, 2013)
Objective: To assess the impact of pregnancy on mortality among HIV-infected Ugandan women initiating antiretroviral therapy (ART).
Design: Prospective cohort study.
Methods: HIV-infected women initiating ART in the ...