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Cytomegalovirus Infections in Ugandan Infants: Newborns, Neonates with Sepsis and Infants with Hydrocephalus
(2019)
Background: Congenital and postnatal cytomegalovirus (CMV) infections in Uganda is prevalent and may compromise the health of Ugandan children. The objective of this study is to
estimate the prevalence of CMV infections ...
Vaginal microbiome topic modeling of laboring Ugandan women with and without fever
(Biofilms and Microbiomes, 2020)
The composition of the maternal vaginal microbiome influences the duration of pregnancy, onset of labor, and even neonatal outcomes. Maternal microbiome research in sub-Saharan Africa has focused on non-pregnant and ...
Placental Decidual Arteriopathy and Vascular Endothelial Growth Factor A Expression Among Women With or Without Human Immunodeficiency Virus
(The Journal of Infectious Diseases, 2021)
Background. Women with human immunodeficiency virus (HIV) (WHIV) are at higher risk of adverse birth outcomes. Proposed mechanisms for the increased risk include placental arteriopathy (vasculopathy) and maternal vascular ...
Altered Maternal Antibody Profiles in Women With Human Immunodeficiency Virus Drive Changes in Transplacental Antibody Transfer
(Clinical Infectious Diseases, 2022)
Background: Human immunodeficiency virus (HIV)–exposed, uninfected (HEU) children have a higher risk of severe infection, but the causes are poorly understood. Emerging data point to altered antibody transfer in women with ...
Placental decidual arteriopathy and vascular endothelial growth factor A (VEGF-A) expression among women with and without HIV
(The Journal of Infectious Diseases, 2021)
Background: Women with HIV (WHIV) are at higher risk of adverse birth outcomes. Proposed mechanisms for the increased risk include placental arteriopathy (vasculopathy) and maternal vascular malperfusion (MVM) due to ...
Chronic Placental Inflammation Among Women Living With HIV in Uganda
(ournal of Acquired Immune Deficiency Syndromes, 2020)
Background: HIV-exposed, uninfected (HEU) children have poorer early-life outcomes than HIV-unexposed children. The determinants of adverse health outcomes among HEU children are poorly understood but may result from chronic ...
Maternal anemia is associated with adverse obstetric, neonatal and placental outcomes in Mbarara, Uganda
(American Journal of Obstetrics & Gynecology, 2020)
Objective: Maternal anemia is a significant risk factor for maternal morbidity and mortality, affecting 42% of pregnant women globally. In addition to increased risk of death from peripartum hemorrhage, anemic pregnant ...
Building Perinatal Pathology Research Capacity in Sub-Saharan Africa
(Frontiers in Medicine, 2022-07-08)
Introduction: Over two million stillbirths and neonatal deaths occur in sub-Saharan Africa (sSA) annually. Despite multilateral efforts, reducing perinatal mortality has been slow. Although targeted pathologic investigation ...