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Improving the Specificity of Plasmodium falciparum Malaria Diagnosis in High- Transmission Settings with a Two-Step Rapid Diagnostic Test and Microscopy Algorithm
(Journal of Clinical Microbiology, 2017)
Poor specificity may negatively impact rapid diagnostic test (RDT)-based diagnostic strategies for malaria. We performed real-time PCR on a subset of subjects who had undergone diagnostic testing with a multiple-antigen ...
Effi cacy and safety of artemether–lumefantrine compared with quinine in pregnant women with uncomplicated Plasmodium falciparum malaria: an open-label, randomised, non-inferiority trial
(The Lancet infectious diseases, 2010)
Background: Malaria in pregnancy is associated with maternal and fetal morbidity and mortality. In 2006, WHO recommended use of artemisinin-based combination treatments during the second or third trimesters, but data on ...
Comparison of Capillary Versus Venous Blood for the Diagnosis of Plasmodium falciparum Malaria Using Rapid Diagnostic Tests
(The Journal of infectious diseases, 2021)
We enrolled 250 febrile children in western Uganda to compare the results of malaria rapid diagnostic tests (RDTs) when using capillary vs venous blood. Participants were tested with 4 different RDT types. Polymerase chain ...
Detection of Plasmodium Species by High-Resolution Melt Analysis of DNA from Blood Smears Acquired in Southwestern Uganda
(Journal of Clinical Microbiology, 2017-10-02)
Microscopic diagnosis of malaria using Giemsa-stained blood smears is the standard of care in resource-limited settings. These smears represent a potential source of DNA for PCR testing to confirm Plasmodium infections or ...
Malaria is an uncommon cause of adult sepsis in south-western Uganda
(Malaria Journal, 2013-05-01)
Background: Malaria is often considered a cause of adult sepsis in malaria endemic areas. However, diagnostic limitations can make distinction between malaria and other infections challenging. Therefore, the objective of ...
Permethrin‑treated baby wraps for the prevention of malaria: results of a randomized controlled pilot study in rural Uganda
(Malaria Journal, 2022)
Background: Progress against malaria has stalled and may even be slipping backwards in high-burden countries. This is due to a range of factors including insecticide resistance and mosquito feeding behaviours that limit ...