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Acute and sub-acute oral toxicity of aqueous whole leaf and green rind extracts of Aloe vera in Wistar rats
(BMC complementary medicine and therapies, 2022)
Background: Several local communities in Central, Western, Eastern, and Northern regions of Uganda have been using the whole leaf extracts of Aloe vera (L.) Burm. f. (Asphodelaceae) in the treatment of various ailments. ...
Ethno medical knowledge and traditional use of Aristolochia bracteolata Lam. for malaria among local communities in Jubek State of South Sudan: A cross-sectional survey
(Journal of Ethnopharmacology, 2009)
Ethnopharmacological relevance: The recognized challenges to access conventional antimalarial medicines could have contributed to the extensive use of Aristolochia bracteolata Lam. (Aristolochiaceae) to manage malaria in ...
Evaluation of the adverse effects of Dracaena steudneri Engl. stem bark aqueous extract in Wistar rats
(African Journal of Pharmacy and Pharmacology, 2021)
Safety of medicinal plants/products is one of the major areas that require more attention because of the high rate at which consumers use medicinal plants/products due to their availability and accessibility. Dracaena ...
The safety and efficacy of Momordica charantia L. in animal models of type 2 diabetes mellitus: A systematic review and meta-analysis
(Phytotherapy Research, 2021)
Type 2 diabetes mellitus is a chronic hyperglycemic condition due to progressively impaired glucose regulation. Momordica charantia L. could potentially improve hyperglycemia because its fruit extracts can alleviate insulin ...
Acute and repeated-dose toxicity of Echinops kebericho Mesfin essential oil
(Toxicology Reports, 2021)
Echinops kebericho Mesfin is used for the management of various diseases and fumigation during child birth. This study investigated acute and repeated-dose toxicity of E. kebericho M. essential oils (EOs). The study was ...
Systematic review and meta-analysis protocol for efficacy and safety of Momordica charantia L. on animal models of type 2 diabetes mellitus
(Systematic Reviews, 2020-01-08)
Background: Studies on several preclinical models of type 2 diabetes mellitus have been conducted to establish the hypoglycemic activity of Momordica charantia L. Concerned with appropriateness of these models, we designed ...
The efficacy and safety of Momordica charantia L. in animal models of type 2 diabetes mellitus; A systematic review and meta-analysis
(BioRxiv, 2019-06-24)
Background: Momordica charantia L. (Cucurbitaceae) has been used to control hyperglycemia in people with type 2 diabetes mellitus in Asia, South America, and Africa for decades. However, a meta-analysis of clinical trials ...
Quality Control for the Safety of Natural Products
(Poisonous Plants and Phytochemicals in Drug Discovery, 2020)
The World Health Organization (WHO) has defined a medicinal plant as any plant in which one or more of its parts consists of substances that are used for the synthesis of beneficial drugs [1]. These plants need to be studied ...