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Capacity Building in Sub-Saharan Africa as Part of the INTENSE-TBM Project During the COVID-19 Pandemic
(Infectious Diseases and Therapy, 2022)
Tuberculous meningitis (TBM) is the most severe and disabling form of tuberculosis (TB), with at least 100,000 cases per year and a mortality rate of up to 50% in individuals co-infected with human immunodeficiency virus ...
High Mobility Group Box 1 (HMGB1) and HIV-Associated Kaposi’s Sarcoma in Africa
(Academia.edu, 2015)
Other than Kaposi’s sarcoma-associated herpesvirus (KSHV) and CD4+ T cell lymphopenia, the mechanisms responsible for KS are poorly understood. Additional mechanisms must exist in sub-Saharan Africa given that only a ...
Bedside measures of malnutrition and association with mortality in hospitalized adults
(Clinical nutrition, 2015)
Background & aims: The impact of malnutrition on the outcomes of hospitalized adults in resource limited settings such as sub-Saharan Africa (SSA) is not fully described. We aimed to determine the association between ...
A Causal Framework for Understanding the Effect of Losses to Follow-up on Epidemiologic Analyses in Clinic-based Cohorts: The Case of HIV-infected Patients on Antiretroviral Therapy in Africa
(American journal of epidemiology, 2012)
Although clinic-based cohorts are most representative of the ‘‘real world,’’ they are susceptible to loss to follow-up. Strategies for managing the impact of loss to follow-up are therefore needed to maximize the value of ...
Adherence to HIV antiretroviral therapy among pregnant and postpartum women during the Option B+ era: 12-month cohort study in urban South Africa and rural Uganda
(Journal of the International AIDS Society, 2020)
Introduction: We conducted a cohort study to understand patterns of anti-retroviral therapy (ART) adherence during pregnancy, postpartum and non-pregnancy follow-up among women initiating ART in public clinics offering ...
Single-Dose Liposomal Amphotericin B Treatment for Cryptococcal Meningitis
(New England Journal of Medicine, 2022-03-24)
Background: Cryptococcal meningitis is a leading cause of human immunodeficiency virus (HIV)–related death in sub-Saharan Africa. Whether a treatment regimen that includes a single high dose of liposomal amphotericin B ...
Outcomes of patients with severe infection in Uganda according to adherence to the World Health Organization's Integrated Management of Adolescent and Adult Illness fluid resuscitation guidelines
(Journal of Critical Care, 2017)
Purpose: We determined outcomes in hospitalized patients in Uganda with World Health Organization's Integrated Management of Adolescent and Adult Illness (IMAI) defined septic shock (IMAI-shock) or severe respiratory ...
Unfavorable treatment outcomes among patients with drugresistant TB in Uganda
(The International Journal of Tuberculosis and Lung Disease, 2023)
Background: Drug-resistant TB (DR-TB) remains a significant public health burden and a threat to the progress made in TB control and prevention in sub- Saharan Africa.
Objective: To determine the risk-predictors of poor ...
Hypoglycemia at admission is associated with inhospital mortality in Ugandan patients with severe sepsis
(Critical care medicine, 2011)
Objective—Dysglycemia during sepsis is associated with poor outcomes in resource-rich settings. In resource-limited settings, hypoglycemia is often diagnosed clinically without the benefit of laboratory support. We studied ...
Smoking cessation after engagement in HIV care in rural Uganda
(AIDS care, 2018)
People living with HIV (PLWH) are more likely to smoke compared to HIV-uninfected counterparts, but little is known about smoking behaviors in sub-Saharan Africa. To address this gap in knowledge, we characterized smoking ...