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Sterile Cerebrospinal Fluid Culture at Cryptococcal Meningitis Diagnosis Is Associated with High Mortality
(Journal of Fungi, 2023)
Cryptococcus is the leading cause of AIDS-related meningitis in sub-Saharan Africa. The clinical implications of a sterile cerebrospinal fluid (CSF) culture among individuals diagnosed with cryptococcal meningitis using ...
Rate of clearance of infection is independently associated with clinical outcome in HIV-associated cryptococcal meningitis: analysis of a combined cohort of 262 patients
(Clinical infectious diseases: an official publication of the Infectious Diseases Society of America, 2009)
Background—Progress in therapy of cryptococcal meningitis has been slow because of the lack
of a suitable marker of treatment response. Previously, we demonstrated the statistical power of a
novel endpoint, the rate of ...
Detrimental Outcomes of Unmasking Cryptococcal Meningitis With Recent ART Initiation
(In Open forum infectious diseases, 2018)
Background: Increased antiretroviral therapy (ART) availability has been associated with more patients developing cryptococcosis after ART initiation. Despite this changing epidemiology, data regarding cryptococcal meningitis ...
Tuberculosis in HIV-Associated Cryptococcal Meningitis is Associated with an Increased Risk of Death
(Journal of Clinical Medicine, 2020)
Tuberculosis (TB) and cryptococcal meningitis are leading causes of morbidity and mortality
in advanced HIV disease. Data are limited on TB co-infection among individuals with cryptococcal meningitis. We performed a ...
Cryptococcosis in pregnancy and the postpartum period: Case series and systematic review with recommendations for management
(Medical Mycology, 2020)
Cryptococcal meningitis causes 15% of AIDS-related deaths. Optimal management and clinical outcomes of pregnant women with cryptococcosis are limited to case reports, as pregnant women are often excluded from research. ...
Cerebrospinal Fluid Early Fungicidal Activity as a Surrogate Endpoint for Cryptococcal Meningitis Survival in Clinical Trials
(Clinical Infectious Diseases, 2020)
Background: In cryptococcal meningitis phase 2 clinical trials, early fungicidal activity (EFA) of Cryptococcus clearance from cerebrospinal fluid (CSF) is used as a surrogate endpoint for all-cause mortality. The Food and ...
Human Immune Response Varies by the Degree of Relative Cryptococcal Antigen Shedding
(Open Forum Infectious Diseases, 2016)
Background: Cerebrospinal fluid (CSF) cryptococcal glucuronoxylomannan antigen (CrAg) titers generally correlate with quantitative fungal culture burden; however, correlation is not precise. Some patients have higher CrAg ...
The Mouse Inhalation Model of Cryptococcus neoformans Infection Recapitulates Strain Virulence in Humans and Shows that Closely Related Strains Can Possess Differential Virulence
(Infection and Immunity, 2019)
Cryptococcal meningitis (CM) causes high rates of HIV-related mortality, yet the Cryptococcus factors influencing patient outcome are not well understood. Pathogen-specific traits, such as the strain genotype and degree ...