Browsing Research Articles by Title
Now showing items 88-107 of 224
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Gender differences among patients with drug resistant tuberculosis and HIV co‑infection in Uganda: a countrywide retrospective cohort study
(BMC Infectious Diseases, 2021)Background: Gender differences among patients with drug resistant tuberculosis (DRTB) and HIV co-infection could affect treatment outcomes. We compared characteristics and treatment outcomes of DRTB/HIV co-infected men and ... -
A General Report of the Prevalence and Correlates of Peripheral Arterial Disease in Southwestern Uganda
(Journal of the American College of Cardiology, 2013)Background: Chronic non-communicable diseases (NCDs) are increasingly recognized as a public health priority in developing countries, with the greatest regional increase in NCD deaths over the next decade predicted in ... -
Genotypic and Mechanistic Characterization of Subtype- Specific HIV Adaptation to Host Cellular Immunity
(Journal of virology, 2018)The extent to which viral genetic context influences HIV adaptation to human leukocyte antigen (HLA) class I-restricted immune pressures remains incompletely understood. The Ugandan HIV epidemic, where major pandemic group ... -
Global Dialysis Perspective: Uganda
(Kidney 360, 2022)Kidney injury and CKD are common complications of infectious and non-communicable diseases (NCDs) alike. Patients with advanced kidney disease need RRT in the form of dialysis or renal transplantation. Both these interventions ... -
GPS-measured distance to clinic, but not self-reported transportation factors, are associated with missed HIV clinic visits in rural Uganda
(AIDS, 2013)Objective—Studies of the association between transportation barriers and HIV-related health outcomes have shown both positive and negative effects, possibly because a reliable, validated measure of transportation barriers ... -
Handheld Point-of-Care Cerebrospinal Fluid Lactate Testing Predicts Bacterial Meningitis in Uganda
(The American Journal of Tropical Medicine and Hygiene, 2013)We validated a handheld point-of-care lactate (POCL) monitor’s ability to measure lactate in cerebrospinal fluid (CSF) and diagnose bacterial meningitis in Uganda. There was a strong linear correspondence between POCL and ... -
Head and Neck Squamous Cell Carcinoma in Western Uganda: Disease of Uncertainty and Poor Prognosis
(Sage, 2018)Objectives Patients with head and neck squamous cell carcinoma (HNSCC) have symptoms that masquerade as benign conditions, resulting in late presentations. The objective is to describe characteristics and stages of patients ... -
Hearing loss among patients on treatment for drug-resistant tuberculosis in Uganda
(South Sudan Medical Journal, 2021-08)Introduction: Second-line injectable therapy using aminoglycosides (AG) like kanamycin, amikacin or capreomycin is associated with irreversible hearing loss. We aimed to determine the incidence and predictors of hearing ... -
High acceptability for cell phone text messages to improve communication of laboratory results with HIV-infected patients in rural Uganda: a cross-sectional survey study
(BMC medical informatics and decision making, 2012)Background: Patient-provider communication is a major challenge in resource-limited settings with large catchment areas. Though mobile phone usership increased 20-fold in Africa over the past decade, little is known about ... -
High dose oral and intravenous rifampicin for improved survival from adult tuberculous meningitis: a phase II open-label randomised controlled trial (the RifT study) [version 1; referees: 2 approved]
(Wellcome open researc, 2018)Background: Tuberculous meningitis (TBM) has 44% (95%CI 35-52%) in-hospital mortality with standard therapy in Uganda. Rifampicin, the cornerstone of TB therapy, has 70% oral bioavailability and ~10-20% cerebrospinal fluid ... -
High Mobility Group Box 1 (HMGB1) and HIV-Associated Kaposi’s Sarcoma in Africa
(Academia.edu, 2015)Other than Kaposi’s sarcoma-associated herpesvirus (KSHV) and CD4+ T cell lymphopenia, the mechanisms responsible for KS are poorly understood. Additional mechanisms must exist in sub-Saharan Africa given that only a ... -
High Mortality Associated with Unmasking Cryptococcal Meningitis
(Boston, 2018)Introduction: Increased antiretroviral therapy (ART) availability in Africa has led to more patients developing cryptococcosis after ART initiation. Despite this changing epidemiology, data regarding cryptococcal meningitis ... -
High Prevalence of Metabolic Syndrome and Cardiovascular Disease Risk Among People with HIV on Stable ART in Southwestern Uganda
(AIDS patient care and STDs, 2016)The objectives of this study were to determine the epidemiology and correlates of cardiovascular disease (CVD) risk among Ugandans on first-line antiretroviral therapy (ART). We conducted a cross-sectional study at an HIV ... -
High-Dose Oral and Intravenous Rifampicin for the Treatment of Tuberculous Meningitis in Predominantly Human Immunodeficiency Virus (HIV)-Positive Ugandan Adults: A Phase II Open-Label Randomized Controlled Trial
(Clinical Infectious Diseases, 2021)Background: High-dose rifampicin may improve outcomes of tuberculous meningitis (TBM). Little safety or pharmacokinetic (PK) data exist on high-dose rifampicin in human immunodeficiency virus (HIV) coinfection, and no ... -
Higher ART Adherence is Associated with Lower Systemic Inflammation in Treatment-naïve Ugandans who Achieve Virologic Suppression
(Journal of acquired immune deficiency syndromes, 2018)Background: Residual systemic inflammation persists despite suppressive antiretroviral therapy (ART) and is associated with non-AIDS clinical outcomes. We aimed to evaluate the association between ART adherence and ... -
Higher baseline CD4 cell count predicts treatment interruptions and persistent viremia in patients initiating ARVs in rural Uganda
(Journal of acquired immune deficiency syndromes, 2013)We examined the association between CD4 cell count and adherence in a cohort of Ugandans initiating ARVs. Outcomes were: a) adherence<90%; b) any treatment interruptions>72 hours; c) number of treatment interruptions; and ... -
Highly Active Antiretroviral Therapy and Increased Use of Contraceptives Among HIV-Positive Women During Expanding Access to Antiretroviral Therapy in Mbarara, Uganda
(Andia, I., Kaida, A., Maier, M., Guzman, D., Emenyonu, N., Pepper, L., ... & Hogg, R. S. (2009). Highly active antiretroviral therapy and increased use of contraceptives among HIV-positive women during expanding access to antiretroviral therapy in Mbarara, Uganda. American journal of public health, 99(2), 340-347., 2009)Objectives: We investigatedwhether the prevalence of contraceptive use among women who are HIV positive varied according to use of highly active antiretroviral therapy (HAART) in Mbarara, Uganda. Methods: We used data ... -
HIV Infection Is an Independent Predictor of Mortality Among Adults with Reduced Level of Consciousness in Uganda
(The American journal of tropical medicine and hygiene, 2022)The clinical epidemiology of adults admitted with reduced level of consciousness (LOC) in sub-Saharan Africa (SSA) and the impact of HIV infection on the risk of mortality in this population is unknown. We secondarily ... -
HIV-Associated Cryptococcal Meningitis Occurring at Relatively Higher CD4 Counts
(The Journal of infectious diseases, 2019)Background: Cryptococcal meningitis can occur in persons with less-apparent immunosuppression. We evaluated clinical characteristics and outcomes of persons with HIV-related Cryptococcus presenting with higher CD4 ... -
HIV-infected women on antiretroviral treatment in Uganda have increased mortality during pregnant and postpartum periods
(AIDS, 2013)Objective: To assess the impact of pregnancy on mortality among HIV-infected Ugandan women initiating antiretroviral therapy (ART). Design: Prospective cohort study. Methods: HIV-infected women initiating ART in the ...