Browsing Research Articles by Title
Now showing items 151-170 of 224
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Patient choice improves self-efficacy and intention to complete tuberculosis preventive therapy in a routine HIV program setting in Uganda
(PLoS One, 2021)A 12-dose weekly regimen of rifapentine plus isoniazid (3HP) is recommended for the prevention of active tuberculosis (TB); however, it is unclear whether 3HP should be provided by directly observed therapy (DOT) or ... -
Patient-provider experiences with chronic non-communicable disease care during COVID-19 lockdowns in rural Uganda: A qualitative analysis
(Plos one, 2023)Non-communicable diseases (NCDs) are a growing health burden in Sub-Saharan Africa and especially Uganda, where they account for over one third of all deaths. During the COVID-19 pandemic, public health control measures ... -
Perceived barriers and facilitators to antiretroviral therapy adherence among youth aged 15-24 years at a regional HIV clinic in SouthWestern Uganda: a qualitative study
(African Health Sciences, 2022)Introduction: South-Western region has the second highest HIV prevalence in Uganda. Youth aged 15-24 have shown poor adherence to antiretroviral therapy compared to the older cohorts. Previous studies from other regions ... -
Performance of a histidine-rich protein 2 rapid diagnostic test, paracheck pf ® , for detection of malaria infections in Ugandan pregnant women
(The American Society of Tropical Medicine and Hygiene, 2012)Improved laboratory diagnosis is critical to reduce the burden of malaria in pregnancy. Peripheral blood smears appear less sensitive than Plasmodium falciparum histidine-rich protein 2–based rapid diagnostic tests (RDTs) ... -
Persistently elevated intracranial pressure in cryptococcal meningitis– 76 therapeutic lumbar punctures
(Medical Mycology Case Reports, 2023)Cryptococcal meningitis still remains the most common form of adult meningitis in sub-Saharan Africa, due to the burden of HIV/AIDS. Increased intracranial pressure (ICP) is a major complication of cryptococcosis and ... -
Point-of-Care C-Reactive Protein Testing to Facilitate Implementation of Isoniazid Preventive Therapy for People Living with HIV
(Journal of acquired immune deficiency syndromes, 2014)Background—Symptom-based tuberculosis screening identifies less than one-third of eligible HIV-infected patients as candidates for isoniazid preventive therapy (IPT). We evaluated whether testing for C-reactive protein ... -
Point-of-Care Diagnosis and Prognostication of Cryptococcal Meningitis With the Cryptococcal Antigen Lateral Flow Assay on Cerebrospinal Fluid
(Oxford University Press, 2013)The cryptococcal antigen (CRAG) lateral flow assay (LFA) had 100% sensitivity and specificity on cerebrospinal fluid samples. Pretreatment LFA titers correlated with quantitative cultures (R2 = 0.7) and predicted 2- and ... -
Population attributable fraction of esophageal squamous cell carcinoma due to smoking and alcohol in Uganda
(BMC Cancer, 2016)Background: Despite the high rates and regional variation of esophageal squamous cell carcinoma (ESCC) in East Africa, the contributions of smoking and alcohol to the ESCC burden in the general population are unknown. ... -
Population Pharmacokinetics and Significant Under-Dosing of Anti-Tuberculosis Medications in People with HIV and Critical Illness
(Antibiotics, 2021)Critical illness from tuberculosis (TB) bloodstream infection results in a high case fatality rate for people living with human immunodeficiency virus (HIV). Critical illness can lead to altered pharmacokinetics and ... -
Positive Deviance for Dual-Method Promotion among Women in Uganda: A Qualitative Study
(International journal of environmental research and public health, 2020-07-12)Dual-method use is the most reliable form of protection against unintended pregnancies and human immunodeficiency virus/sexually transmitted infections (HIV/STIs). Although dual-method use remains uncommon among women in ... -
Post-traumatic stress disorder among persons with HIV who engage in heavy alcohol consumption in southwestern Uganda
(BMC psychiatry, 2021)Background: We aimed to describe the prevalence of PTSD symptoms and its associated factors in persons living with HIV (PLWH) in Uganda who engage in heavy alcohol use. Methods: We analyzed baseline data from the Drinkers ... -
Post-traumatic stress disorder, psychiatric comorbidities and associated factors among refugees in Nakivale camp in southwestern Uganda
(Springer Nature, 2020)Background: Armed conflict in Africa has led to displacement of over 24.2 million people, more than 1.4 million of whom are living in Uganda. Studies show that refugees living in Ugandan refugee settlements are at increased ... -
A pragmatic approach to managing antiretroviral therapy-experienced patients diagnosed with HIVassociated cryptococcal meningitis: impact of antiretroviral therapy adherence and duration
(AIDS, 2020)Cryptococcal meningitis accounts for 15% of all HIV related deaths [1]. The overall number of cryptococcal meningitis cases has remained relatively stable in many low-to-middle income countries (LMICs) despite increasing ... -
Pre-treatment integrase inhibitor resistance is uncommon in ART-naïve individuals with HIV-1 subtype A1 and D infections in Uganda
(AIDS, 2020)Objective: Dolutegravir (DTG) is now a preferred component of first-line antiretroviral therapy (ART). However, prevalence data on natural resistance to integrase inhibitors (INSTIs) in circulating non-subtype B HIV-1 in ... -
Prevalence and Clinical Impacts of HIV-1 Intersubtype Recombinants in Uganda Revealed by Near-Full-Genome Population and Deep Sequencing Approaches
(Lee, G. Q., Bangsberg, D. R., Mo, T., Lachowski, C., Brumme, C. J., Zhang, W., ... & Harrigan, P. R. (2017). Prevalence and clinical impacts of HIV-1 intersubtype recombinants in Uganda revealed by near-full-genome population and deep sequencing approaches. AIDS (London, England), 31(17), 2345., 2017)Objectives: To estimate prevalence, examine time trends, and test for clinical correlates and outcomes associated with HIV-1 intersubtype recombination under a full-genome sequencing context in a rural community in Mbarara, ... -
Prevalence and correlates for ADHD and relation with social and academic functioning among children and adolescents with HIV/AIDS in Uganda
(Springer Nature, 2017)Background: Aim of this study was to determine the prevalence of attention-deficit/hyperactivity disorder (ADHD), its associated correlates and relations with clinical and behavioural problems among children and adolescents ... -
Prevalence and factors associated with depression symptoms among school‑going adolescents in Central Uganda
(Bio Med Central, 2016)Background: Depression in adolescents constitutes a global public health concern. However, data on its prevalence and associated factors are limited in low income countries like Uganda. Methods: Using a cross-sectional ... -
Prevalence and glasgow outcome scale score of severe head injury in Mbarara regional referral hospital
(Research Square, 2020)Background: Traumatic brain injury (TBI) is a common cause of death in the Intensive care units and emergency departments with an estimated annual global mortality of 1.5 million people as a result of severe TBI. The ... -
Prevalence and grade of diabetic peripheral neuropathy among known diabetic patients in rural Uganda
(Frontiers in Clinical Diabetes and Healthcare, 2022)Background: Diabetic peripheral neuropathy (DPN) is the most common complication of diabetes mellitus (DM). Approximately 50% of diabetic patients are estimated to develop DPN, depending on disease duration and diabetic ... -
Prevalence and Virologic Consequences of Transmitted HIV-1 Drug Resistance in Uganda
(AIDS research and human retroviruses, 2014)Few reports have examined the impact of HIV-1 transmitted drug resistance (TDR) in resource-limited settings where there are fewer regimen choices and limited pretherapy/posttherapy resistance testing. In this study, we ...