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Surveillance of Plasmodium falciparum pfcrt haplotypes in southwestern Uganda by high resolution melt analysis.
(BMC Public Health, 2021)
Background: Chloroquine (CQ) resistance is conferred by mutations in the Plasmodium falciparum CQ resistance transporter (pfcrt). Following CQ withdrawal for anti‑malarial treatment, studies across malaria‑endemic countries ...
Evaluation of the SD Bioline TB Ag MPT64 test for identification of Mycobacterium tuberculosis complex from liquid cultures in Southwestern Uganda
(AOSIS, 2017)
Background: To confirm presence of Mycobacterium tuberculosis complex, some tuberculosis culture laboratories still rely on para-nitrobenzoic acid (PNB), a traditional technique that requires sub-culturing of clinical ...
Lowenstein-Jensen Selective Medium for Reducing Contamination in Mycobacterium tuberculosis Culture
(JCM, 214-07)
We compared Mycobacterium tuberculosis sputum culture recovery and contamination rates between Lowenstein-Jensenmedium(LJ)containing the following decontaminants and LJalone:(i)PANTA(n 299),(ii) Selectatab-MB(n 299),and(iii) ...
MinION Whole-Genome Sequencing in Resource-Limited Settings: Challenges and Opportunities
(Current Clinical Microbiology Reports, 2022-11)
Purpose of Review The introduction of MinION whole-genome sequencing technology greatly increased and simplified complete genome sequencing in various fields of science across the globe. Sequences have been generated from ...
Cryptococcus neoformans Genotypic Diversity and Disease Outcome among HIV Patients in Africa
(Journal of Fungi, 2022)
Cryptococcal meningoencephalitis, a disease with poor patient outcomes, remains the most prevalent invasive fungal infection worldwide, accounting for approximately 180,000 deaths each
year. In several areas of sub-Saharan ...
Detection of Plasmodium Species by High-Resolution Melt Analysis of DNA from Blood Smears Acquired in Southwestern Uganda
(Journal of Clinical Microbiology, 2017-10-02)
Microscopic diagnosis of malaria using Giemsa-stained blood smears is the standard of care in resource-limited settings. These smears represent a potential source of DNA for PCR testing to confirm Plasmodium infections or ...
Status of pulmonary fungal pathogens among individuals with clinical features of pulmonary tuberculosis at Mbarara University Teaching Hospital in Southwestern Uganda
(Therapeutic advances in infectious disease, 2021)
Background: Pulmonary mycoses are important diseases of the respiratory tract caused by pulmonary fungal pathogens. These pathogens are responsible for significant morbidity and mortality rates worldwide; however, less ...
Status of pulmonary fungal infections among individuals with clinical signs of pulmonary tuberculosis at a University Teaching Hospital in Southwestern Uganda
(Research square, 2021)
Background: Pulmonary mycoses are very important diseases of the respiratory tract and are responsible for significant morbidity and mortality rates worldwide. However, less attention has been paid to them. In this study ...
Rifampicin and isoniazid drug resistance among patients diagnosed with pulmonary tuberculosis in southwestern Uganda
(PloS one, 2021)
Multidrug-resistant tuberculosis (MDR-TB) has become a major threat to the control of tuberculosis globally. Uganda is among the countries with a relatively high prevalence of tuberculosis despite significant control ...
Antimicrobial Resistance Patterns and Molecular Characterization of Klebsiella pneumoniae in Clinical Isolates at Mbarara Regional Referral Hospital
(Advances in Infectious Diseases, 2019-08)
Background: Klebsiella pneumoniae is one of the most frequent opportunistic pathogens causing a range of infections and being resistant for beta- lactamases (ESBL) and Carbapenemases.
Aim: The aim of the present study ...