Browsing Research Article by Title
Now showing items 73-92 of 123
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Laboratory and simulated semi-field larvicidal efficacy of Aframomum angustifolium (Sonn.) K. Schum and Tagetes patula essential oils against Anopheles gambiae
(Journal of Natural Pesticide Research, 2024)Introduction: Malaria is a vector-borne, important public health problem spread by mosquitoes in tropical regions. The use of synthetic insecticides for mosquito control has been linked to insecticide resistance and ... -
Ligand-protein interactions of plant-isolated (9z,12z)-octadeca-9,12-dienoic acid with B-ketoacyl-Acp synthase (KasA) in potential anti-tubercular drug designing
(Scientific African, 2021)Mycobacterium tuberculosis remains one of the world’s contributors to mortality. With the emergence of SARS-CoV-2 coinfections, patients with TB are predisposed to being more heavily weighed down by COVID-19 disease and ... -
Ligand-protein interactions of plant-isolated (9z,12z)-octadeca-9,12-dienoic acid with B-ketoacyl-Acp synthase (KasA) in potential anti-tubercular drug designing
(Scientific African, 2020)Mycobacterium tuberculosis remains one of the world’s contributors to mortality. With the emergence of SARS-CoV-2 coinfections, patients with TB are predisposed to being more heavily weighed down by COVID-19 disease and ... -
The meaning of caring for patients with cancer among traditional medicine practitioners in Uganda: A grounded theory approach
(PLOS Global Public Health, 2023)Traditional medicine practitioners (TMPs) are a critical part of healthcare systems in many sub-Saharan African countries and play vital roles in caring for patients with cancer. Despite some progress in describing TMPs’ ... -
Microbial and physical evaluation of selected cough syrups sold at peripheral drug outlets in Bushenyi District, South Western Uganda
(African Journal of Pharmacy and Pharmacology, 2023)Syrups, being non-sterile liquid pharmaceutical formulations, are prone to microbial contamination. The most common microbial contaminants are bacteria and fungi. Contamination of oral liquid pharmaceuticals makes them ... -
Mitigating the burden of adverse drug reactions in older inpatients: short commentary
(Aging Communications, 2022)Studies have consistently identified older age as a predictor of adverse drug reaction (ADR) and the related adverse. The safety data collected during the premarketing phase is lacking due to the omission of distinctive ... -
New Putative Antimicrobial Candidates: In silico Design of Fish-Derived Antibacterial Peptide-Motifs
(Frontiers in Bioengineering and Biotechnology, 2020)Antimicrobial resistance remains a great threat to global health. In response to the World Health Organizations’ global call for action, nature has been explored for novel and safe antimicrobial candidates. To date, fish ... -
Off‑label antibiotic use among paediatric in‑patients: a mixed‑method prospective study at a tertiary hospital in southwestern Uganda
(International Journal of Clinical Pharmacy, 2020)Background: The off-label use of drugs to treat children is a global practice attributed to the traditional exclusion of children from clinical trials mainly due to practical and ethical reasons. Off-label drug use carries ... -
Overview of processed excipients in ocular drug delivery: Opportunities so far and bottlenecks
(Heliyon, 2023-12-23)Ocular drug delivery presents a unique set of challenges owing to the complex anatomy and physiology of the eye. Processed excipients have emerged as crucial components in overcoming these challenges and improving the ... -
Pharmacognostic and phytochemical studies as an invaluable approach for correct identification of medicinal plants: The case of Artemisia vulgaris L. substituted for Artemisia annua L. in Western Uganda
(TMR Integrative Medicine, 2023)Different parts of Artemisia vulgaris L. (A. vulgaris) are ethno-medicinally used as an emmenagogue and for the treatment of ailments such as malaria fever, ulcers, and cancer. However, anecdotal evidence shows that the ... -
Pharmacological reflection of plants traditionally used to manage diabetes mellitus in Tanzania
(Journal of Ethnopharmacology, 2020-12-25)Ethnopharmacological relevance: The increasing national prevalence of diabetes mellitus (DM) and its complications have overstretched the health care system in Tanzania and influenced patients to use herbal medicines as ... -
Pharmacology, phytochemistry, and toxicity profiles of phytolacca dodecandra L’Hér
(Infectious Diseases: Research and Treatment, 2020)Introduction: Phytolacca dodecandra L’Hér. is a native plant of sub-Saharan Africa and Madagascar which is traditionally used for various ailments. Concerned with the scope of the available evidence, we designed a scoping ... -
Physical properties and compactability of various blends of fully gelatinised and pregelatinised maize starch
(Pharmaceutical and Biosciences Journal, 2020)The use of pregelatinised maize starch in direct compression as a sole binder produces tablets with relatively low tensile strength. Fully gelatinised maize starch possesses better binding properties but its use is limited ... -
Phytochemical and Antidiabetic Evaluation of the Methanolic Stem Bark Extract of Spathodea campanulata (P. Beauv.) Bignoniaceae
(Pharmacognosy Journal, 2016-05)Background: Spathodea campanulata (P. Beauv.) Bignoniaceae extract (SCE) is one of many herbal medicines used widely in Ugandan traditional medicine for various ailments. Generally most of these herbal medicines are yet ... -
Poor glycemic control and the contributing factors among type 2 diabetes mellitus patients attending outpatient diabetes clinic at Mbarara regional referral hospital, Uganda
(Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, 2021)Background: Glycemic control is associated with long-term complications in type 2 diabetes management. However, updated reports on glycemic control that are crucial to reducing diabetes mellitus complications remain scarce. ... -
Potential benefits of antiviral African medicinal plants in the management of Viral infections
(Frontiers in Pharmacology, 2021-12-24)Background: Viruses cause various human diseases, some of which become pandemic outbreaks. This study synthesized evidence on antiviral medicinal plants in Africa which could potentially be further studied for viral ... -
Predictors of hospital‑acquired adverse drug reactions: a cohort of Ugandan older adults
(BMC Geriatrics, 2022)Background: Globally, it is estimated that the number of older adults will become 2 billion by 2050. The identification of the predictors of adverse drug reaction (ADR) in hospitalized older patients is crucial to the ... -
Preliminary phytochemical investigation on Mama powder — an approved herbal antimalarial in Nigeria
(Am J Ethnomed, 2018)Malaria is an endemic disease in Africa where one out of four mortalities is reported regularly. Despite the discovery of artemisinin-combination therapy (ACT), high mortality rate persists due to chloroquine-resistant ... -
Prevalence and Factors Associated With Adverse Drug Events Among Patients On Dolutegravir-Based Regimen At The Immune Suppression Syndrome Clinic of Mbarara Regional Referral Hospital, Uganda: A Retrospective Cross-Sectional Study.
(Research square, 2022)Background: Highly Active Antiretroviral Therapy is efficacious in suppression of Human Immunodeficiency Virus (HIV) however; it is associated with numerous toxicities hence great effort has been put into development of ... -
Prevalence and factors associated with adverse drug events among patients on dolutegravir‑based regimen at the Immune Suppression Syndrome Clinic of Mbarara Regional Referral Hospital, Uganda: a mixed design study
(AIDS Research and Therapy, 2022)Background: In low income countries such as Uganda progress has been made towards achieving the United Nations AIDS programme 95-95-95 target however efforts are still impeded by pretreatment drug resistance and adverse ...