Browsing Research Article by Title
Now showing items 79-98 of 123
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New Putative Antimicrobial Candidates: In silico Design of Fish-Derived Antibacterial Peptide-Motifs
(Frontiers in Bioengineering and Biotechnology, 2020)Antimicrobial resistance remains a great threat to global health. In response to the World Health Organizations’ global call for action, nature has been explored for novel and safe antimicrobial candidates. To date, fish ... -
Off‑label antibiotic use among paediatric in‑patients: a mixed‑method prospective study at a tertiary hospital in southwestern Uganda
(International Journal of Clinical Pharmacy, 2020)Background: The off-label use of drugs to treat children is a global practice attributed to the traditional exclusion of children from clinical trials mainly due to practical and ethical reasons. Off-label drug use carries ... -
Overview of processed excipients in ocular drug delivery: Opportunities so far and bottlenecks
(Heliyon, 2023-12-23)Ocular drug delivery presents a unique set of challenges owing to the complex anatomy and physiology of the eye. Processed excipients have emerged as crucial components in overcoming these challenges and improving the ... -
Pharmacognostic and phytochemical studies as an invaluable approach for correct identification of medicinal plants: The case of Artemisia vulgaris L. substituted for Artemisia annua L. in Western Uganda
(TMR Integrative Medicine, 2023)Different parts of Artemisia vulgaris L. (A. vulgaris) are ethno-medicinally used as an emmenagogue and for the treatment of ailments such as malaria fever, ulcers, and cancer. However, anecdotal evidence shows that the ... -
Pharmacological reflection of plants traditionally used to manage diabetes mellitus in Tanzania
(Journal of Ethnopharmacology, 2020-12-25)Ethnopharmacological relevance: The increasing national prevalence of diabetes mellitus (DM) and its complications have overstretched the health care system in Tanzania and influenced patients to use herbal medicines as ... -
Pharmacology, phytochemistry, and toxicity profiles of phytolacca dodecandra L’Hér
(Infectious Diseases: Research and Treatment, 2020)Introduction: Phytolacca dodecandra L’Hér. is a native plant of sub-Saharan Africa and Madagascar which is traditionally used for various ailments. Concerned with the scope of the available evidence, we designed a scoping ... -
Physical properties and compactability of various blends of fully gelatinised and pregelatinised maize starch
(Pharmaceutical and Biosciences Journal, 2020)The use of pregelatinised maize starch in direct compression as a sole binder produces tablets with relatively low tensile strength. Fully gelatinised maize starch possesses better binding properties but its use is limited ... -
Phytochemical and Antidiabetic Evaluation of the Methanolic Stem Bark Extract of Spathodea campanulata (P. Beauv.) Bignoniaceae
(Pharmacognosy Journal, 2016-05)Background: Spathodea campanulata (P. Beauv.) Bignoniaceae extract (SCE) is one of many herbal medicines used widely in Ugandan traditional medicine for various ailments. Generally most of these herbal medicines are yet ... -
Poor glycemic control and the contributing factors among type 2 diabetes mellitus patients attending outpatient diabetes clinic at Mbarara regional referral hospital, Uganda
(Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, 2021)Background: Glycemic control is associated with long-term complications in type 2 diabetes management. However, updated reports on glycemic control that are crucial to reducing diabetes mellitus complications remain scarce. ... -
Potential benefits of antiviral African medicinal plants in the management of Viral infections
(Frontiers in Pharmacology, 2021-12-24)Background: Viruses cause various human diseases, some of which become pandemic outbreaks. This study synthesized evidence on antiviral medicinal plants in Africa which could potentially be further studied for viral ... -
Predictors of hospital‑acquired adverse drug reactions: a cohort of Ugandan older adults
(BMC Geriatrics, 2022)Background: Globally, it is estimated that the number of older adults will become 2 billion by 2050. The identification of the predictors of adverse drug reaction (ADR) in hospitalized older patients is crucial to the ... -
Preliminary phytochemical investigation on Mama powder — an approved herbal antimalarial in Nigeria
(Am J Ethnomed, 2018)Malaria is an endemic disease in Africa where one out of four mortalities is reported regularly. Despite the discovery of artemisinin-combination therapy (ACT), high mortality rate persists due to chloroquine-resistant ... -
Prevalence and Factors Associated With Adverse Drug Events Among Patients On Dolutegravir-Based Regimen At The Immune Suppression Syndrome Clinic of Mbarara Regional Referral Hospital, Uganda: A Retrospective Cross-Sectional Study.
(Research square, 2022)Background: Highly Active Antiretroviral Therapy is efficacious in suppression of Human Immunodeficiency Virus (HIV) however; it is associated with numerous toxicities hence great effort has been put into development of ... -
Prevalence and factors associated with adverse drug events among patients on dolutegravir‑based regimen at the Immune Suppression Syndrome Clinic of Mbarara Regional Referral Hospital, Uganda: a mixed design study
(AIDS Research and Therapy, 2022)Background: In low income countries such as Uganda progress has been made towards achieving the United Nations AIDS programme 95-95-95 target however efforts are still impeded by pretreatment drug resistance and adverse ... -
Prevalence and risk factors of nephrotoxicity among adult cancer patients at Mbarara regional referral hospital
(Dove Medical Press Limited., 2021-10-17)Background: Nephrotoxicity is common among cancer patients, yet some anti-cancer drugs, for example, platinum derivatives, are nephrotoxic and have narrow therapeutic indices. If nephrotoxicity is not managed, it can ... -
Prevalence and factors associated with adverse drug reactions among heart failure patients hospitalized at Mbarara Regional Referral Hospital, Ugand
(BMC Cardiovascular Disorders, 2022)Background: Adverse drug reaction (ADR) of medications remains an obstacle to achieving optimal disease outcomes. This study aimed to assess the prevalence and associated factors of ADR among Heart failure (HF) patients ... -
Prevalence and factors associated with potential drug-drug interactions in prescriptions presented at private pharmacies in Mbarara city, southwestern Uganda
(BMC Pharmacology and Toxicology, 2023)Background: Drug-drug interactions (DDIs) influence the effectiveness of medication and thus determine the treatment outcomes of diseases managed with pharmacotherapy. This study aimed to determine the prevalence, severity, ... -
Prevalence of Medication Errors and the Associated Factors: A Prospective Observational Study Among Cancer Patients at Mbarara Regional Referral Hospital
(Cancer Management and Research, 2021)Background: Medication error is one of the most common medical errors in the practice of modern medicine. Among cancer patients receiving chemotherapy, medication errors can be potentially harmful given the narrow therapeutic ... -
Prevalence of the Use of Herbal Medicines among Patients with Cancer: A Systematic Review and Meta-Analysis
(Evidence-Based Complementary and Alternative Medicine, 2021-05)Background. Although herbal medicines are used by patients with cancer in multiple oncology care settings, the magnitude of herbal medicine use in this context remains unclear. ) e purpose of this review was to establish ... -
Prevalence, characteristics and predicting risk factors of adverse drug reactions among hospitalized older adults: A systematic review and meta-analysis
(SAGE Open Medicine, 2021)Background: Occurrence of adverse drug reactions is a major global health problem mostly affecting older adults. Identifying the magnitude and predictors of adverse drug reactions is crucial to developing strategies to ...