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dc.contributor.authorOlds, Peter K.
dc.contributor.authorKiwanuka, Julius P.
dc.contributor.authorNansera, Denis
dc.contributor.authorHuang, Yong
dc.contributor.authorBacchetti, Peter
dc.contributor.authorJin, Chengshi
dc.contributor.authorGandhi, Monica
dc.contributor.authorHaberer, Jessica E.
dc.date.accessioned2022-05-09T13:07:12Z
dc.date.available2022-05-09T13:07:12Z
dc.date.issued2015
dc.identifier.citationOlds, P. K., Kiwanuka, J. P., Nansera, D., Huang, Y., Bacchetti, P., Jin, C., ... & Haberer, J. E. (2015). Assessment of HIV antiretroviral therapy adherence by measuring drug concentrations in hair among children in rural Uganda. AIDS care, 27(3), 327-332.en_US
dc.identifier.urihttp://ir.must.ac.ug/xmlui/handle/123456789/1876
dc.description.abstractCurrent tools for measuring medication adherence have significant limitations, especially among pediatric populations. We conducted a prospective observational study to assess the use of antiretroviral (ARV) drug levels in hair for evaluating antiretroviral therapy (ART) adherence among HIV-infected children in rural Uganda. Three-day caregiver recall, 30-day visual analog scale (VAS), Medication Event Monitoring System (MEMS), and unannounced pill counts and liquid formulation weights (UPC) were collected monthly over a one-year period. Hair samples were collected quarterly and analyzed for nevirapine (NVP) levels, and plasma HIV RNA levels were collected every six months. Among children with at least one hair sample collected, we used univariable random intercept linear regression models to compare log transformed NVP concentrations with each adherence measure, and the child’s age, sex, and CD4 count percentage (CD4%). One hundred and twenty-one children aged 2–10 years were enrolled in the study; 74 (61%) provided at least one hair sample, and the mean number of hair samples collected per child was 1.9 (standard deviation [SD] 1.0). Three-day caregiver recall, VAS, and MEMS were found to be positively associated with increasing NVP concentration in hair, although associations were not statistically significant. UPC was found to have a non-significant negative association with increasing hair NVP concentration. In conclusion, NVP drug concentrations in hair were found to have non-significant, although generally positive, associations with other adherence measures in a cohort of HIV-infected children in Uganda. Hair collection in this population proved challenging, suggesting the need for community education and buy-in with the introduction of novel methodologiesen_US
dc.description.sponsorshipNIH/NIAID (American Recovery and Reinvestment Act Funds) [grant number 3R01AI065233-05S2].en_US
dc.language.isoen_USen_US
dc.publisherAIDS Careen_US
dc.subjectAntiretroviral therapyen_US
dc.subjectHuman immunodeficiency virusen_US
dc.subjectAdherenceen_US
dc.subjectChildrenen_US
dc.subjectUgandaen_US
dc.titleAssessment of HIV antiretroviral therapy adherence by measuring drug concentrations in hair among children in rural Ugandaen_US
dc.typeArticleen_US


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