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dc.contributor.authorRautenberg, Tamlyn A.
dc.contributor.authorNg, Shu Kay
dc.contributor.authorGeorge, Gavin
dc.contributor.authorMoosa, Mahomed-Yunus S.
dc.contributor.authorMcCluskey, Suzanne M.
dc.contributor.authorGilbert, Rebecca F.
dc.contributor.authorPillay, Selvan
dc.contributor.authorAturinda, Isaac
dc.contributor.authorArd, Kevin L.
dc.contributor.authorMuyindike, Winnie R.
dc.contributor.authorMusinguzi, Nicholas
dc.contributor.authorMasette, Godfrey
dc.contributor.authorPillay, Melendhran
dc.contributor.authorMoodley, Pravi
dc.contributor.authorBrijkumar, Jaysingh
dc.contributor.authorGandhi, Rajesh T.
dc.contributor.authorJohnson, Brent
dc.contributor.authorSunpath, Henry
dc.contributor.authorBwana, Mwebesa B.
dc.contributor.authorMarconi, Vincent C.
dc.contributor.authorSiedner, Mark J.
dc.date.accessioned2023-09-29T09:35:29Z
dc.date.available2023-09-29T09:35:29Z
dc.date.issued2023
dc.identifier.citationRautenberg, T. A., Ng, S. K., George, G., Moosa, M. Y. S., McCluskey, S. M., Gilbert, R. F., ... & Siedner, M. J. (2023). Determinants of health-related quality of life in people with Human Immunodeficiency Virus, failing first-line treatment in Africa. Health and Quality of Life Outcomes, 21(1), 1-8.en_US
dc.identifier.urihttp://ir.must.ac.ug/xmlui/handle/123456789/3129
dc.description.abstractBackground: Antiretroviral treatment improves health related quality of life (HRQoL) of people with human immunodeficiency virus (PWH). However, one third initiating first-line treatment experience virological failure and the determinants of HRQoL in this key population are unknown. Our study aims to identify determinants of among PWH failing antiretroviral treatment in sub-Saharan Africa. Methods: We analysed data from a cohort of PWH having virological failure (> 1,000 copies/mL) on first-line ART in South Africa and Uganda. We measured HRQoL using the EuroQOL EQ-5D-3L and used a two-part regression model to obtain by-country analyses for South Africa and Uganda. The first part identifies risk factors that were associated with the likelihood of participants reporting perfect health (utility = 1) versus non-perfect health (utility < 1). The second part identifies risk factors that were associated with the EQ-5 L-3L utility scores for participants reporting non-perfect health. We performed sensitivity analyses to compare the results between the two-part model using tobit models and ordinary least squares regression. Results: In both countries, males were more likely to report perfect health and participants with at least one comorbidity were less likely to report perfect health. In South Africa, participants with side effects and in Uganda those with opportunistic infections were also less likely to report perfect health. In Uganda, participants with 100% ART adherence were more likely to report perfect health. In South Africa, high HIV viral load, experiencing ART side effects, and the presence of opportunistic infections were each associated with lower HRQoL, whereas participants with 100% ART adherence reported higher HRQoL. In Uganda participants with lower CD4 count had lower HRQoL. Conclusion: Markers of advanced disease (opportunistic infection, high viral load, low CD4), side effects, comorbidities and lack of ART adherence negatively impacted HRQoL for PWH experiencing virological failure.en_US
dc.description.sponsorshipPresident’s Emergency Plan for AIDS Relief and the National Institute of Allergy and Infectious Diseases of the National Institutes of Health (NIH R01 AI124718).en_US
dc.language.isoen_USen_US
dc.publisherHealth and Quality of Life Outcomesen_US
dc.subjectVirological failureen_US
dc.subjectHealth state utility valuesen_US
dc.subjectEQ-5Den_US
dc.subjectHIVen_US
dc.subjectHealth related quality-of-lifeen_US
dc.subjectTwo part regressionen_US
dc.titleDeterminants of health-related quality of life in people with Human Immunodeficiency Virus, failing first-line treatment in Africaen_US
dc.typeArticleen_US


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