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dc.contributor.authorMiller, Kathleen
dc.contributor.authorMuyindike, Winnie
dc.contributor.authorMatthews, Lynn T.
dc.contributor.authorKanyesigye, Michael
dc.contributor.authorSiedner, Mark J.
dc.date.accessioned2023-10-23T12:23:25Z
dc.date.available2023-10-23T12:23:25Z
dc.date.issued2017
dc.identifier.citationMiller, K., Muyindike, W., Matthews, L. T., Kanyesigye, M., & Siedner, M. J. (2017). Program implementation of option B+ at a President's emergency plan for AIDS relief-supported HIV clinic improves clinical indicators but not retention in Care in Mbarara, Uganda. AIDS patient care and STDs, 31(8), 335-341.en_US
dc.identifier.urihttp://ir.must.ac.ug/xmlui/handle/123456789/3204
dc.description.abstract2013 WHO guidelines for prevention of mother to child transmission recommend combination antiretroviral therapy (ART) for all pregnant women, regardless of CD4 count (Option B/B+). We conducted a retrospective analysis of data from a government-operated HIV clinic in Mbarara, Uganda before and after implementation of Option B+ to assess the impact on retention in care. We limited our analysis to women not on ART at the time of their first reported pregnancy with CD4 count >350. We fit regression models to estimate relationships between calendar period (Option A vs. Option B+) and the primary outcome of interest, retention in care. One thousand and sixty-two women were included in the analysis. Women were more likely to start ART within 6 months of pregnancy in the Option B+ period (68% vs. 7%, p < 0.0001) and had significantly greater increases in CD4 count 1 year after pregnancy (+172 vs. -5 cells, p < 0.001). However, there was no difference in the proportion of women retained in care 1 year after pregnancy (73% vs. 70%, p = 0.34). In models adjusted for age, distance to clinic, marital status, and CD4 count, Option B+ was associated with a non-significant 30% increased odds of retention in care at 1 year [adjusted odds ratio (AOR) = 1.30, 95% CI 0.98–1.73, p = 0.06]. After transition to an Option B+ program, pregnant women with CD4 count >350 were more likely to initiate combination therapy; however, interventions to mitigate losses from HIV care during pregnancy are needed to improve the health of women, children, and families.en_US
dc.language.isoenen_US
dc.publisherAIDS patient care and STDsen_US
dc.subjectPMTCTen_US
dc.subjectPregnancyen_US
dc.subjectRetention in careen_US
dc.titleProgram Implementation of Option B– at a President’s Emergency Plan for AIDS Relief-Supported HIV Clinic Improves Clinical Indicators But Not Retention in Care in Mbarara, Ugandaen_US
dc.typeArticleen_US


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