dc.contributor.author | Nansera, D. | |
dc.contributor.author | Bajunirwe, F. | |
dc.contributor.author | Elyanu, P. | |
dc.contributor.author | Asiimwe, C. | |
dc.contributor.author | Amanyire, G. | |
dc.contributor.author | Graziano, F. M. | |
dc.date.accessioned | 2021-12-02T12:21:55Z | |
dc.date.available | 2021-12-02T12:21:55Z | |
dc.date.issued | 2012-08-02 | |
dc.identifier.citation | Nansera, D., Bajunirwe, F., Elyanu, P., Asiimwe, C., Amanyire, G., & Graziano, F. M. (2012). Mortality and loss to follow-up among tuberculosis and HIV co-infected patients in rural southwestern Uganda. The International journal of tuberculosis and lung disease, 16(10), 1371-1376. | en_US |
dc.identifier.uri | http://ir.must.ac.ug/xmlui/handle/123456789/1063 | |
dc.description.abstract | BACKGROUND: We describe the presentation and outcome of care among patients with tuberculosis (TB) and human immunodeficiency virus (HIV) co-infection from a prospective observational cohort in Uganda.
METHODS: We analysed basic demographics, CD4+ counts, time of initiating antiretroviral therapy (ART), clinical and haematological parameters and outcome of care of 386 patients enrolled between February 2007 and March 2010.
RESULTS: At presentation, 56.7% of the patients were sputum-positive, 89.9% had new TB infection, 62.7% had wasting, 78.7% were anaemic, 72.1% had a CD4+ count of <200 cells/mm3, 20.2% had pneumonia, 50.3% had oral thrush and 1.3% had Kaposi’s sarcoma. Patients developing TB within 3 months of starting ART were less likely to have wasting, to be anaemic or to have a CD4+ count of <100 cells/mm3. The cure, default and death rates were respectively 54.3%, 24% and 16%. At 8 months, 53 (13.7%) were confirmed dead, 119 (30.8%) were lost to follow-up, 28 (7.3%) were transferred out and 1 (0.3%) had treatment failure. Mortality and loss to follow-up were associated with failure to start ART and having a CD4+ count of <200 cells/mm3.
CONCLUSION: In Uganda, TB-HIV patients present with severe immune suppression and are at increased risk of death and loss to follow-up, particularly those not on ART. There is need for early identification and improved follow-up of TB-HIV co-infected patients | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | The International Journal of Tuberculosis and Lung Disease | en_US |
dc.subject | TB-HIV | en_US |
dc.subject | Mortality | en_US |
dc.subject | Loss to follow-up | en_US |
dc.title | Mortality and loss to follow-up among tuberculosis and HIV co-infected patients in rural southwestern Uganda | en_US |
dc.type | Article | en_US |