Department of Internal Medicine: Recent submissions

Now showing items 1-20 of 253

    • Self-Rated Competence of Ugandan Healthcare Workers to Obtain Informed Consent for Autopsy 

      Bongomin, Felix; Kibone, Winnie; Nantale, Ritah; Lukande, Robert; Bromley, Ruth; Muzoora, Conrad; Hamer, Davidson H. (The American journal of tropical medicine and hygiene, 2024)
      We examined the self-rated competence of Ugandan healthcare workers (HCWs) in obtaining informed consent for autopsies, considering the challenges of low autopsy acceptance rates globally. In September and October 2023, ...

    • Point-of-care urine tenofovir testing to predict HIV drug resistance among individuals with virologic failure 

      Mccluskey, Suzanne M.; Govender, Katya; Adamson, John; Gandhi, Monica; Spinelli, Matthew A.; Moosa, Mahomed-Yunus; Muyindike, Winnie; Moodley, Pravi; Pillay, Melendhran; Masette, Godfrey; Sunpath, Henry; Pillay, Selvan; Chen, Geoffrey; Hedt-Gauthier, Bethany; Marconi, Vincent C.; Siedner, Mark J. (AIDS, 2023)
      Objective: We sought to evaluate the utility of a point-of-care (POC) urine tenofovir (TFV) assay, developed to objectively assess adherence, to predict HIV drug resistance (HIVDR) in people failing first-line antiretroviral ...

    • Frequency of fungal pathogens in autopsy studies of people who died with HIV in Africa: a scoping review 

      Bongomin, Felix; Kibone, Winnie; Atulinda, Linda; Morgan, Bethan; Ocansey, Bright; Storer, Isabelle S.R.; Rhijn, Norman van; Muzoora, Conrad; Denning, David W.; Hamer, Davidson H. (Clinical Microbiology and Infection, 2023)
      Background: Fungal infections are common in HIV-infected individuals and significantly contribute to mortality. However, a substantial number of cases are undiagnosed before death. Objective: To determine the frequency ...

    • Influences on Adherence to Antiretroviral Therapy (ART) in Early-Stage HIV Disease: Qualitative Study from Uganda and South Africa 

      Ware, Norma C.; Wyatt, Monique A.; Pisarski, Emily E.; Bwana, Bosco M.; Orrell, Catherine; Asiimwe, Stephen; Amanyire, Gideon; Musinguzi, Nicholas; Bangsberg, David R.; Haberer, Jessica E.; META Study Team (AIDS and Behavior, 2020)
      Realization of optimal treatment and prevention benefits in the era of universal antiretroviral therapy (ART) and “U=U” (undetectable = untransmittable) requires high adherence at all stages of HIV disease. This article ...

    • Seemingly Unrelated Regression analysis of the Cost and Health-Related Quality of Life Outcomes of the REVAMP randomised clinical trial 

      Rautenberg, Tamlyn A.; Ng, Shu Kay; George, Gavin; Moosa, Mahomed-Yunus S.; McCluskey, Suzanne M.; Gilbert, Rebecca F.; Pillay, Selvan; Aturinda, Isaac; Ard, Kevin L.; Muyindike, Winnie; Musinguzi, Nicholas; Masette, Godfrey; Pillay, Melendhran; Moodley, Pravi; Brijkumar, Jaysingh; Gandhi, Rajesh T.; Johnson, Brent; Sunpath, Henry; Bwana, Mwebesa B.; Marconi, Vincent C.; Siedner, Mark J. (Value in health regional issues, 2023)
      Objective: To evaluate the nine-month cost and health-related quality of life outcomes of resistance versus viral load testing strategies to manage virological failure in low-middle income countries. Methods: We analysed ...

    • Provider perceptions of young people living with HIV and unhealthy alcohol use in Southwestern Uganda: a qualitative study 

      Odokonyero, Raymond Felix ;  Nakasujja, Noeline; Turiho, Andrew ; Sanyu, Naomi ;  Muyindike, Winnie R.; Nansera, Denis ; Semitala, Fred ; Kamya, Moses R. ; Katahoire, Anne R. ; Hahn, Judith A. ; Camlin, Carol C. ; Muhwezi, Wilson W.  (Addiction Science & Clinical Practice, 2024)
      Background: Unhealthy alcohol use is a common public health problem in HIV care settings in Africa and it affects the HIV continuum of care. In Uganda and other low-income countries, HIV care providers are a key resource ...

    • Psychometric assessment of the Runyankole-translated Marlowe-Crowne Social Desirability Scale among persons with HIV in Uganda 

      Silva, Cristina Espinosa da; Fatch, Robin; Emenyonu, Nneka; Muyindike, Winnie; Adong, Julian; Rao, Sowmya R.; Chamie, Gabriel; Ngabirano, Christine; Tumwegamire, Adah; Kekibiina, Allen; Marson, Kara; Beesiga, Brian; Sanyu, Naomi; Katusiime, Anita; Hahn, Judith A. (BMC Public Health, 2024)
      Background: Social desirability can negatively affect the validity of self-reported measures, including underreporting of stigmatized behaviors like alcohol consumption. The Marlowe-Crowne Social Desirability Scale (SDS) ...

    • Diagnostic Prediction Model for Tuberculous Meningitis: An Individual Participant Data Meta-Analysis 

      Stadelman-Behar, Anna M.; Tiffin, Nicki; Ellis, Jayne; Creswell, Fiona V.; Ssebambulidde, Kenneth; Nuwagira, Edwin; Richards, Lauren; Lutje, Vittoria; Hristea, Adriana; et al (The American Journal of Tropical Medicine and Hygiene, 2024)
      No accurate and rapid diagnostic test exists for tuberculous meningitis (TBM), leading to delayed diagnosis. We leveraged data from multiple studies to improve the predictive performance of diagnostic models across different ...

    • Population Effectiveness of Dolutegravir Implementation in Uganda: A Prospective Observational Cohort Study (DISCO), 48-Week Results 

      McCluskey, Suzanne M.; Muyindike, Winnie R.; Nanfuka, Victoria; Omoding, Daniel; Komukama, Nimusiima; Barigye, Ian T.; Kansiime, Lydia; Tumusiime, Justus; Aung, Taing N.; Stuckwisch, Ashley; Hedt-Gauthier, Bethany; Marconi, Vincent C.; Moosa, Mahomed-Yunus S.; Pillay, Deenan; Giandhari, Jennifer; Lessells, Richard; Gupta, Ravindra K.; Siedner, Mark J. (The Journal of Infectious Diseases, 2024)
      Background: Tenofovir/lamivudine/dolutegravir (TLD) is the preferred first-line antiretroviral therapy (ART) regimen for people with HIV (PWH), including those who were previously virologically suppressed on nonnucleoside ...

    • Mid–Upper Arm Circumference Is a Strong Predictor of Mortality Among Ugandan Adults With HIV-Associated Cryptococcal Meningitis: A Prospective Cohort Study 

      Hale, Gila; Adzemovic, Tessa; Hullsiek, Kathy Huppler; Mulwana, Suzan; Ndyetukira, Jane Francis; Sadiq, Alisat; Kabahubya, Mable; Ayebare, Peruth; Nankungu, Lydia; Namudde, Alice; Namanda, Sylvia; Menya, Grace; Nakitto, Grace; Muzoora, Conrad; Nuwagira, Edwin; Rhein, Joshua; Meya, David B.; Boulware, David R.; Ellis, Jayne; Abassi, Mahsa (Open Forum Infectious Diseases, 2024)
      Background: Mortality among adults diagnosed with HIV-associated cryptococcal meningitis remains high (24%–40%). We hypothesized that nutritional state, as measured by mid–upper arm circumference (MUAC), is a potentially ...

    • Death after cure: Mortality among pulmonary tuberculosis survivors in rural Uganda 

      Baluku, Joseph Baruch; Namanda, Brenda; Namiiro, Sharon; Rwabwera, Diana Karungi; Mwesigwa, Gloria; Namaara, Catherine; Twinomugisha, Bright; Nyirazihawe, Isabella; Nuwagira, Edwin; Kansiime, Grace; Kizito, Enock; Nabukenya-Mudiope, Mary G.; Sekadde, Moorine Penninah; Bongomin, Felix; Senfuka, Joshua; Olum, Ronald; Byaruhanga, Aggrey; Munabi, Ian; Kiguli, Sarah (International Journal of Infectious Diseases, 2024)
      Objectives: To determine the incidence of mortality and its predictors among pulmonary tuberculosis (PTB) survivors treated at a rural Ugandan tertiary hospital. Methods: We conducted a retrospective chart review of data ...

    • How Does Antiretroviral Treatment Attenuate the Stigma of HIV? Evidence from a Cohort Study in Rural Uganda 

      Tsai, Alexander C.; . Bangsberg, David R; Bwana, Mwebesa; Haberer, Jessica E.; Frongillo, Edward A.; Muzoora, Conrad; Kumbakumba, Elias; Hunt, Peter W.; Martin, Jeffrey N.; Weiser, Sheri D. (AIDS and Behavior, 2013)
      Program implementers and qualitative researchers have described how increasing availability of HIV antiretroviral therapy (ART) is associated with improvements in psychosocial health and internalized stigma. To determine ...

    • Endoscopically diagnosed hookworm infestation in an adult with chronic iron infestation in an adult with chronic iron deficiency anaemia 

      Abdirahman, Mohamed Mukhtar; Baruhanga, Emmanuel; Muhumuza, Andrew; Wagubi, Robert; Atwine, Raymond; Tumuhimbise, Christine; Tusiime, Florence; Tuhumwire, Caleb; Lumori, Boniface Amanee Elias (South Sudan Medical Journal, 2024)
      Despite advances in hookworm control and prevention campaigns, the prevalence remains high in sub-Saharan Africa. Iron deficiency anaemia is a major complication in those with prolonged infection, a high hookworm burden, ...

    • Oral Lipid Nanocrystal Amphotericin B for Cryptococcal Meningitis: A Randomized Clinical Trial 

      Boulware, David R.; Atukunda, Mucunguzi; Kagimu, Enock; Musubire, Abdu K.; Akampurira, Andrew; Tugume, Lillian; Ssebambulidde, Kenneth; Kasibante, John; Nsangi, Laura; Mugabi, Timothy; Gakuru, Jane; Kimuda, Sarah; Kasozi, Derrick; Namombwe, Suzan; Turyasingura, Isaac; Rutakingirwa, Morris K.; Mpoza, Edward; Kigozi, Enos; Muzoora, Conrad; Ellis, Jayne; Skipper, Caleb P.; Matkovits, Theresa; Williamson, Peter R.; Williams, Darlisha A.; Fieberg, Ann; Hullsiek, Kathy H.; Abassi, Mahsa; Dai, Biyue; Meya, David B. (Clinical Infectious Diseases, 2023)
      Background: Amphotericin B is the gold standard treatment for severe mycoses. A new orally delivered, less-toxic formulation of amphotericin has been developed. Methods: In our randomized clinical trial, we tested oral ...

    • Implementation of a safer conception programme for HIV- affected men and women in rural Uganda 

      Matthews, Lynn T.; Owembabazi, Moran; Tukwasibwe, Deogratius; Najjuma, Alice; Muyindike, Winnie; Tumwine, John Mary; Hornstein, Benjamin; Bassler, John; Long, Dustin; Gill, Elizabeth; Young, Cynthia; Chitneni, Pooja; Psaros, Christina; Kanyesigye, Micheal; Kalyebara, Paul Kato; Kaida, Angela; Bwana, Mwebesa (Global Public Health, 2024)
      We integrated safer conception care into a Ugandan HIV clinic. People with HIV (PWH), or partnered with a PWH, and desiring children were eligible for the Healthy Families Clinic Program. Clients completed quarterly safer ...

    • Diagnostic performance of fecal Helicobacter pylori antigen test in Uganda 

      Owot, Jacob Canwat; Tuhumwire, Caleb; Tumuhimbise, Christine; Tusiime, Florence; Emmanuel, Byaruhanga; Lumori, Boniface A. E.; Okello, Samson (BMC gastroenterology, 2022)
      We evaluated the diagnostic performance of a qualitative stool antigen test (SAT) in individuals with dyspepsia in rural Uganda using the polymerase chain reaction-based 16S ribosomal RNA assay (16S rRNA) for nucleotide ...

    • Association between biomarkers of inflammation and dyslipidemia in drug resistant tuberculosis in Uganda 

      Baluku, Joseph Baruch ; Nalwanga, Robinah ; Kazibwe, Andrew ;  Olum, Ronald; Nuwagira, Edwin ;  Mugenyi, Nathan; Mulindwa, Frank ;  Bongomin, Felix (Lipids in Health and Disease, 2024)
      Background: Active tuberculosis (TB) significantly increases the risk of cardiovascular disease, but the underlying mechanisms remain unclear. This study aimed to investigate the association between inflammation biomarkers ...

    • Cryptococcal Meningitis and Clinical Outcomes in Persons With Human Immunodeficiency Virus: A Global Vie 

      Person, Anna K.; Crabtree-Ramirez, Brenda; Kim, Ahra; Veloso, Valdiléa; Maruri, Fernanda; Wandeler, Gilles; Fox, Matthew; Moore, Richard; Gill, M. John; Imran, Darma; Nguyen, Kinh Van; Nalitya, Elizabeth; Muyindike, Winnie; Shepherd, Bryan E.; McGowan, Catherine C. (Clinical Infectious Diseases, 2023)
      Background: Cryptococcal meningitis (CM) is a major cause of morbidity and mortality in persons with human immunodeficiency virus (HIV; PWH). Little is known about CM outcomes and availability of diagnostic and treatment ...

    • Participant perspectives on incentives for TB preventative therapy adherence and reduced alcohol use: A qualitative study 

      Appa, Ayesha; Miller, Amanda P.; Fatch, Robin; Kekibiina, Allen; Beesiga, Brian; Adong, Julian; Emenyonu, Nneka; Marson, Kara; Getahun, Monica; Kamya, Moses; Muyindike, Winnie; McDonell, Michael; Thirumurthy, Harsha; Hahn, Judith A.; Chamie, Gabriel; Camlin, Carol S. (PLOS Global Public Health, 2024)
      Economic incentives to promote health behavior change are highly efficacious for substance use disorders as well as increased medication adherence. Knowledge about participants’ experiences with and perceptions of incentives ...

    • Alcohol Consumption in Ugandan HIV-Infected Household-Brewers Versus Non-Brewers 

      Thakarar, Kinna; Asiimwe, Stephen B.; Cheng, Debbie M.; Forman, Leah; Ngabirano, Christine; Muyindike, Winnie R.; Emenyonu, Nneka I.; Samet, Jeffrey H.; Hahn, Judith A. (AIDS and Behavior, 2016)
      The brewing of alcohol in Ugandan households is common, yet little is known about its relationship with alcohol consumption in HIV-infected individuals. We performed a cross-sectional analysis to assess the association ...