Browsing Department of Biochemistry by Author "Aja, Patrick Maduabuchi"
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Combating Lassa Fever in West African Sub-Region: Progress, Challenges, and Future Perspectives
Aloke, Chinyere; Obasi, Nwogo Ajuka; Aja, Patrick Maduabuchi; Emelike, Chinedum Uche; Egwu, Chinedu Ogbonnia; Jeje, Olamide; Edeogu, Chuks Oswald; Onisuru, Olalekan Olugbenga; Orji, Obasi Uche; Achilonu, Ikechukwu (Viruses, 2023)Lassa fever (LF) is a rodent-borne disease that threatens human health in the sub-region of West Africa where the zoonotic host of Lassa virus (LASV) is predominant. Currently, treatment options for LF are limited and since ... -
Cucumeropsis mannii seed oil protects against bisphenol A-induced hepatotoxicity by mitigating inflammation and oxidative stress in rats
Aja, Patrick Maduabuchi; Chukwu, Chinecherem Adanna; Ugwu, Okechukwu Paul-Chima; Ale, Boniface Anthony; Agu, Peter Chinedu; Deusdedi, Tusubira; Chukwu, Darlington C.; l Ani, Onyedika Gabrie; Ekpono, Ezebuilo Ugbala; Ogwoni, Hilary Akobi; Awoke, Joshua Nonso; Ogbu, Patience N.; Aja, Lucy; Ukachi, Oliver Ugochukwu; Orji, Obasi Uche; Nweke, Chinoso Peter; Egwu, Chinedu; Ekpono, Ejike Ugbala; Ewa, Gift Onyinyechi; et al (RPS Pharmacy and Pharmacology Reports, 2024)Objectives: This study looked at how Cucumeropsis mannii seed oil (CMSO) affected male Wistar albino rats’ liver damage caused by bisphenol A (BPA). Methods: The standard HPLC method was used to assess the CMSO’s ... -
Elucidation of chemical profiles and molecular targets of Mondia whitei leave fractions bioactive as novel therapeutics: an in vitro and in silico assay
Onohuean, Hope; Onohuean, Fanny Eseohe; Igbinoba, Sharon Iyobor; Ezeonwumelu, Joseph Obiezu Chukwujekwu; Agu, Peter Chinedu; Ifie, Josiah Eseoghene; Deusdedit, Tusubira; Aja, Patrick Maduabuchi (Journal of Genetic Engineering and Biotechnology, 2022)Background: Mondia whitei root is often used in Africa as a local therapeutic agent for libido enhancement. The fractions of the M. whitei leaves (MWL) lack chemical characterization of their bioactive components and ... -
In-Vivo and In-silico Studies Revealed the Molecular Mechanisms of Colocasia esculenta Phenolics as Novel Chemotherapy against Benign Prostatic Hyperplasia via inhibition of 5α‒Reductase and α1-Adrenoceptor.
Tusubira, Deusdedit; Munezero, Jonasi; Agu, Peter Chinedu; Ajayi, Clement Olusoji; Oloro, Joseph; Namale, Nathiim; Ssedyabane, Frank; Nakiguli, Caroline Kiwanuka; Adegboyega, Abayomi E.; Aja, Patrick Maduabuchi (Research Square, 2023)Benign Prostatic Hyperplasia (BPH) is a major cause of lower urinary tract infections and erectile dysfunction thus a major contributor to lowering the quality of life among older men. In this study, we investigated the ... -
UCP-LF and other assay methods for schistosome circulating anodic antigen between 1978 and 2022
Fasogbon, Ilemobayo Victor; Aja, Patrick Maduabuchi; Ondari, Erick Nyakundi; Adebayo, Ismail; Ibitoye, Olukayode Adebola; Egesa, Moses; Tusubira, Deusdedit; Sasikumar, Swamiappan; Onohuean, Hope (Biology Methods and Protocol, 2023)Detection of circulating anodic antigen (CAA) is known for its high sensitivity in diagnosing schistosomiasis infection, even in low-prevalence settings. The Up-Converting Phosphor-Lateral Flow (UCP-LF) assay developed in ...