dc.contributor.author | Siedner, Mark J | |
dc.contributor.author | Kim, June-Ho | |
dc.contributor.author | Nakku, Ruth Sentongo | |
dc.contributor.author | Bibangambah, Prossy | |
dc.contributor.author | Hemphill, Linda | |
dc.contributor.author | Triant, Virginia A | |
dc.contributor.author | Haberer, Jessica E | |
dc.contributor.author | Martin, Jeffrey N | |
dc.contributor.author | Mocello, A. Rain | |
dc.contributor.author | BoumII, Yap | |
dc.contributor.author | Kwon, Douglas S | |
dc.contributor.author | Tracy, Russell P | |
dc.contributor.author | Burdo, Tricia | |
dc.contributor.author | Huang, Yong | |
dc.contributor.author | Cao, Huyen | |
dc.contributor.author | Okello, Samson | |
dc.contributor.author | Bangsberg, David R | |
dc.contributor.author | Hunt, Peter W | |
dc.date.accessioned | 2022-02-17T09:56:29Z | |
dc.date.available | 2022-02-17T09:56:29Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Siedner, M. J., Kim, J. H., Nakku, R. S., Bibangambah, P., Hemphill, L., Triant, V. A., ... & Hunt, P. W. (2016). Persistent immune activation and carotid atherosclerosis in HIV-infected Ugandans receiving antiretroviral therapy. The Journal of infectious diseases, 213(3), 370-378. | en_US |
dc.identifier.uri | http://ir.must.ac.ug/xmlui/handle/123456789/1490 | |
dc.description.abstract | Background.
Human immunodefificiency virus (HIV) infection and associated immune activation predict the risk of cardiovascular disease in resource-rich areas. Less is known about these relationships in sub-Saharan Africa.
Methods.
Beginning in 2005, we enrolled subjects in southwestern Uganda into a cohort at the time of antiretroviral therapy (ART) initiation. Multiple immune activation measures were assessed before and 6 months after ART initiation. Beginning in 2013, participants aged >40 years underwent metabolic profifiling, including measurement of hemoglobin A1c and lipid levels and carotidultrasonography. We fifit regression models to identify traditional and HIV-specifific correlates of common carotid intima media thickness (CCIMT).
Results.
A total of 105 participants completed carotid ultrasonography, with a median completion time of 7 years following ART initiation. Age, low-density lipoprotein cholesterol level, and pre-ART HIV load were correlated with CCIMT. No association was found between CCIMT and any pre-ART biomarkers of immune activation. However, in multivariable models adjusted for cardiovascular disease risk factors, lower absolute levels of soluble CD14 and interleukin 6 and greater declines in the CD14 level and kynurenine-tryptophan ratio after 6 months of ART predicted a lower CCIMT years later (P < .01).
Conclusions.
Persistent immune activation despite ART-mediated viral suppression predicts the future atherosclerotic burden among HIV-infected Ugandans. Future work should focus on clinical correlates of these relationships, to elucidate the long-term health priorities for HIV-infected people in the region | en_US |
dc.description.sponsorship | This work was supported by the National Institutes
of Health (grants R21HL124712, K23MH099916, R56AI100765,
R21AI078774, R01MH054907, P01AI027763 and P01AI076174), the Har vard Center for AIDS Research, the Doris Duke Charitable Foundation, and
the Sullivan Family Foundation | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | The Journal of Infectious Diseases | en_US |
dc.subject | HIV/AIDS | en_US |
dc.subject | Uganda | en_US |
dc.subject | aging | en_US |
dc.subject | inflammation | en_US |
dc.subject | atherosclerosis | en_US |
dc.subject | carotid intima media thickness | en_US |
dc.subject | antiretroviral therapy | en_US |
dc.title | Persistent immune activation and carotid atherosclerosis in HIV-infected Ugandans receiving antiretroviral therapy | en_US |
dc.type | Article | en_US |