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Appetite Suppressing Activity of Rumex Usambarensis Leaf and Stem Aqueous Extract in Wistar Albino Female Rats: an in vivo Experimental Study
(Journal of Experimental Pharmacology, 2024)Background: The burden of obesity and overweight associated morbidity and mortality is increasing in epidemic proportions worldwide. Suppression of appetite is one of the mechanisms that has been shown to reduce weight. ... -
Preclinical immunomodulatory activity of COVIDEX® herbal product developed for supportive treatment of COVID-19 in Uganda
(African Journal of Pharmacy and Pharmacology, 2024)The outbreak of the COVID-19 pandemic due to the SARSCoV-2 virus caused international lockdown with devastating effects on global health. In Africa, most people resorted to the use of herbal products for the prevention and ... -
Impact of Artemisia annua and Moringa oleifera on Viral Load, T Cell Activation, and Exhaustion in Ugandan People Living with HIV/AIDS (PLWH)
(African Journal of Pharmacy and Pharmacology, 2024)Highly active antiretroviral therapy (HAART) effectively controls HIV replication in HIV-positive individuals, but chronic immune activation persists, leading to increased virus replication, T cell depletion, and exhaustion, ... -
Anticancer potential of delphinidin and its derivatives: therapeutic and mechanistic insights
(Medicinal Chemistry Research, 2024)Anthocyanins are water-soluble naturally occurring flavonoids present in fruits, flowers, leaves, and roots of fruit plants and vegetables. One of the important anthocyanidin components of red wine and berries is delphinidin ... -
Prevalence and risk factors of chemotherapy- induced oral mucositis among adult cancer patients at the cancer unit of Mbarara Regional Referral Hospital
(Asia‐Pacific Journal of Clinical Oncology, 2024)Background: Chemotherapy is a common treatment for cancer, but it is associated with adverse drug reactions like oral mucositis. This condition destroys basal cells in the oral mucosal layer, causing inflammation and ... -
Comparison of Antibacterial Activities of Fermented with those of Unfermented Annona muricata (L) Fruit Extracts
(International Journal for Microbiology and Applied sciences, 2015)Fermentation is known to enhance antibacterial activities of some plant products. The research aimed to compare the antibacterial activities of the fermented with those of unfermented fruits of Annona muricata, obtained ... -
Impact of Global Health Scholarship Programs in the Faculty of Medicine at Mbarara University of Science and Technology
(International Medical Education, 2024)In recognition of the critical role of residency programs in narrowing health care inequalities, Global Health scholarships were introduced at Mbarara University of Science and Technology (MUST) in 2011. Since then, at ... -
Effectiveness of Jena DM® Herbal Formulation as Complementary Therapy to Conventional Oral Hypoglycemic Agents in Type-2 Diabetes Mellitus: A Quasi-Experimental Study
(Cureus, 2024)Background: There is vast preclinical evidence that indicates that extracts from several Artemisia plant species have significant antidiabetic benefits. However, clinical evidence is limited to this effect. Objective: We ... -
A Comparison Analysis on Remdesivir, Favipiravir, Hydroxychloroquine, Chloroquine and Azithromycin in the Treatment of Corona Virus Disease 2019 (Covid-19) - A Review
(World Journal of Pharmacy and Pharmaceutical Sciences, 2020)Background: This comparative study is to ascertain the efficacy and results proven drug used in the management of the novel corona virus disease 19 since most patients admitted are recovering while there is no clinically ... -
Gut-brain axis: A cutting-edge approach to target neurological disorders and potential synbiotic application
(Heliyon, 2024)The microbiota-gut-brain axis (MGBA) represents a sophisticated communication network between the brain and the gut, involving immunological, endocrinological, and neural mediators. This bidirectional interaction is ... -
Appetite Suppressing Activity of Rumex Usambarensis Leaf and Stem Aqueous Extract in Wistar Albino Female Rats: an in vivo Experimental Study
(Journal of Experimental Pharmacology, 2024)Background: The burden of obesity and overweight associated morbidity and mortality is increasing in epidemic proportions worldwide. Suppression of appetite is one of the mechanisms that has been shown to reduce weight. ... -
Prevalence and factors associated with inappropriate anti- diabetic medication therapy among type 2 diabetes mellitus patients at the medical and surgical wards of Mbarara Regional Referral Hospital, Uganda
(Plos one, 2022)Background: Inappropriate Anti-Diabetic Medication Therapy (IADT) refers to a drug-related problem and includes ‘ineffective drug therapy’, ‘unnecessary drug therapy’, ‘dosage too high’, and ‘dosage too low’. This study ... -
An exploratory study on becoming a traditional spiritual healer among Baganda in Central Uganda
(PLOS Global Public Health, 2024)Traditional medicinal knowledge and healing practices of indigenous spiritual healers play important roles in health care, and contribute towards achieving Universal Health Care. Traditional spiritual healers (TSHs) are ... -
Effects of Physalis peruviana L. (leaf crude extracts) on blood glucose and functional biomarkers in streptozotocin-nicotinamide-induced diabetic rats
(Die Pharmazie-An International Journal of Pharmaceutical Sciences, 2024)Promoting antidiabetic phytomedicines necessitates evidence-based preclinical investigations, particularly in animal models. The present study investigated the validity of using the streptozotocin-nicotinamide-induced type ... -
Virological Non-Suppression, Non-Adherence and the Associated Factors Among People Living with HIV on Dolutegravir-Based Regimens: A Retrospective Cohort Study
(HIV/AIDS - Research and Palliative Care, 2024)Background: HIV is one of the leading causes of morbidity and mortality, with 39.0 million people living with HIV worldwide, 25.6 million of whom reside in the African region. Highly active anti-retroviral therapy (HAART) ... -
Total polyphenols and antihyperglycemic activity of aqueous fruits extract of Abelmoschus esculentus: Modeling and optimization of extraction conditions
(PloS one, 2021)Aqueous fruits extract of Abelmoschus esculentus (L.) Moench (Malvaceae) has been used traditionally in several communities to alleviate elevated blood glucose levels. However, optimized extraction conditions have not been ... -
Preliminary phytochemical investigation on Mama powder — an approved herbal antimalarial in Nigeria
(Am J Ethnomed, 2018)Malaria is an endemic disease in Africa where one out of four mortalities is reported regularly. Despite the discovery of artemisinin-combination therapy (ACT), high mortality rate persists due to chloroquine-resistant ... -
Effect of Ethanol Leaf Extract of Khat (Catha edulis forsk) on Prefrontal Cortex Oxidative Markers and Hematological Profile of Wistar Rats
(Journal of Scientific Research & Reports, 2021)Aim: This study evaluated the effect of ethanol leaf extract of Catha edulis on the prefrontal cortex oxidative markers and hematological profile of Wistar rats. Study Design: The study design was experimental. Place ... -
A review for selecting medicinal plants commonly used for malaria in Uganda
(African Journal of Pharmacy and Pharmacology, 2020)The menace of current cases of parasite resistance to antimalarial drugs, non- availability and accessibility, and the high costs of pharmaceutical products contribute to the high rate of medicinal plants consumption in ... -
Human Health Risk Assessment of Heavy Metals in Kampala (Uganda) Drinking Water
(Journal of Food Research, 2022)Levels of aluminium, arsenic, cadmium, chromium, copper, iron, mercury, manganese, nickel, lead and zinc in tap water, groundwater-fed protected spring and bottled water were determined. The cancer and non-cancer risks ...