Browsing Department of Pharmacology by Author "Alele, Paul E."
Now showing items 1-15 of 15
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Acute and sub-acute toxicity of Echinops kebericho decoction in rats
Deyno, Serawit; Abebe, Abiy; Tola, Mesfin Asefa; Hymete, Ariya; Bazira, Joel; Makonnen, Eyasu; Alele, Paul E. (BMC Complementary Medicine and Therapies, 2020)Background: Echinops kebericho is widely used for treatment of a variety of diseases including infectious, noninfectious disease and fumigation during child birth. Antibacterial, antimalarial, anti-leshimania, anti-diarrheal ... -
Antibacterial Activities of Echinops kebericho Mesfin Tuber Extracts and Isolation of the Most Active Compound, Dehydrocostus Lactone
Deyno, Serawit; Mtewa, Andrew G.; Hope, Derick; Bazira, Joel; Makonnen, Eyasu; Alele, Paul E. (Frontiers in Pharmacology, 2021-01-25)Echinops kebericho Mesfin is traditionally used for the treatment of various infectious diseases. This study investigated antibacterial activity of the essential oil (EO) and the different fractions of ethanol extract. The ... -
Antifungal Activity of the Essential Oil of Echinops kebericho Mesfin: An In Vitro Study
Beressa, Tamirat Bekele; Deyno, Serawit; Alele, Paul E. (Evidence-Based Complementary and Alternative Medicine, 2020)Background: Echinops kebericho is an endemic medicinal plant in Ethiopia widely used in the treatment of infectious and noninfectious diseases. Essential oils are known for their antibacterial, antifungal, antiviral, ... -
Antimicrobial Bioactivity and GC-MS Analysis of Different Extracts of Corchorus olitorius L Leaves
Nakaziba, Rebecca; Amanya, Sharon Bright; Sesaazi, Crispin Duncan; Byarugaba, Frederick; Ogwal-Okeng, Jasper; Alele, Paul E. (e Scientific World Journal, 2022-09-20)Plants have been used for the treatment of infectious diseases among various communities worldwide with undeniable success. Corchorus olitorius L is used to treat various ailments including infections. However, there are ... -
Association of testosterone levels with socio-demographic characteristics in a sample of Ugandan men
Nansunga, Miriam; Manabe, Yukari C.; Alele, Paul E.; Kasolo, Josephine (African Health Sciences, 2014)Background: Testosterone, a male reproductive hormone, affects several physiological processes, such as sperm production, energy, strength, sexual behavior, sleep and the general wellbeing of men. Normal levels of testosterone ... -
Essential oils as topical anti-infective agents: A systematic review and meta-analysis
Deyno, Serawit; Mtewa, Andrew G.; Abebe, Abiy; Hymete, Ariya; Makonnen, Eyasu; Bazira, Joel; Alele, Paul E. (Complementary therapies in medicine, 2019)Objective: This study summarized evidence on efficacy and safety of essential oils (EOs) in the treatment of topical infections. Design and Setting: Systematic review of clinical trials conducted and reported in accordance ... -
Expression of cFos and brain‑derived neurotrophic factor in cortex and hippocampus of ethanol‑withdrawn male and female rats
Alele, Paul E.; Devaud, Leslie L. (Journal of Pharmacology and Pharmacotherapeutics, 2013)Objective: To map areas of brain activation (cFos) alongside changes in levels of brain-derived neurotrophic factor (BDNF) to provide insights into neuronal mechanisms contributing to previously observed sex differences ... -
Khat (Catha edulis) and ethanol co-dependence modulate seizure expression in a pentylenetetrazol seizure model
Alele, Paul E.; Rujumba, James B. (Journal of Ethnopharmacology, 2011)Ethnopharmacological relevance: Khat is a plant with psychostimulant properties whose parts, mainly leaves and twigs, are chewed for its euphoriant effects. Khat use and ethanol abuse are increasingly becoming global health ... -
Phytochemical Analysis, Acute Toxicity, as well as Antihyperglycemic and Antidiabetic Activities of Corchorus olitorius L. Leaf Extracts
Nakaziba, Rebecca; Lubega, Aloysius; OgwalOkeng, Jasper; Alele, Paul E. (The Scientific World Journal, 2022)Background and Aim: Diabetes mellitus is a metabolic disorder that has no known cure with continuous endeavors to find a therapy for the condition. According to some studies, traditional leafy vegetables could prevent and ... -
Plants used to treat malaria in Nyakayojo sub-county, western Uganda
Stangeland, Torunn; Alele, Paul E.; Katuura, Esther; Lye, Kåre A. (Journal of Ethnopharmacology, 2011)Aim of study: We performed an ethnobotanical study of plants used to treat malaria in Nyakayojo subcounty in south western Uganda because malaria in this region, and in Uganda at large, is still the single most important ... -
Postgraduate medical trainees at a Ugandan university perceive their clinical learning environment positively but differentially despite challenging circumstances: a cross-sectional stud
Alele, Paul E.; Kiptoo, Joshua; Hill‑Besinque, Kathleen (BMC Medical Education, 2023)Purpose: The clinical learning environment is an essential component in health professions’ education. Data are scant on how postgraduate trainees in sub‑Saharan Africa perceive their medical school learning environments, ... -
Safety and antidiarrheal activity of Priva adhaerens aqueous leaf extract in a murine model
Nansunga, Miriam; Barasa, Ambrose; Abimana, Justus; Alele, Paul E.; Kasolo, Josephine (Journal of Ethnopharmacology, 2014)Ethnopharmacological relevance: Priva adhaerens (Forssk.) Chiov., a wildly growing plant, is reported in central Uganda to be. An effective traditional remedy for diarrhea. The objective of this study was to provide a ... -
Seizure vulnerability and anxiety responses following chronic co-administration and acute withdrawal of caffeine and ethanol in a rat model
Matovu, Daniel; Alele, Paul E. (Journal of Basic and Clinical Physiology and Pharmacology, 2018)Background: Caffeine antagonizes the intoxicating effects of alcohol. Consequently, there has been a dramatic global increase in the consumption of caffeinated drinks together with alcohol, especially among young adults. ... -
Traditional Medicinal Vegetables in Northern Uganda: An Ethnobotanical Survey
Nakaziba, Rebecca; Anyolitho, Maxson Kenneth; Amanya, Sharon Bright; Sesaazi, Crispin Duncan; Byarugaba, Frederick; Ogwal-Okeng, Jasper; Alele, Paul E. (International Journal of Food Science, 2021)Background: A wide range of indigenous vegetables grow in Uganda especially during rainy seasons but scarcely during droughts, except those that are commercially grown. Although a number of these vegetables have medicinal ... -
Traditional uses of Corchorus olitorius L in Oyam District, Northern Uganda: A cross-sectional ethnobotanical survey
Nakaziba, Rebecca; Anyolitho, Maxson Kenneth; Amanya, Sharon Bright; Ogwal-Okeng, Jasper; Alele, Paul E. (Research square, 2020)Background: Corchorus olitorius L is a naturally growing green leafy vegetable used for various medicinal purposes worldwide. Several studies conducted elsewhere indicate that the plant is used for treating cardiac ...