Evolving failures in the delivery of HIV care: Lessons from a Ugandan meningitis cohort 2006-2016
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Date
2017Author
Flynn, Andrew G
Meya, David B
Hullsiek, Katherine Huppler
Rhein, Joshua
Williams, Darlisha A
Musubire, Abdu
Morawski, Bozena M
Taseera, Kabanda
Sadiq, Alisat
Ndyatunga, Liberica
Roediger, Mollie
Rajasingham, Radha
Bohjanen, Paul R
Muzoora, Conrad
Boulware, David R
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Background: Investments in HIV care in sub-Saharan Africa have increased the number of people aware of their status and receiving antiretroviral therapy (ART), yet HIV/AIDS mortality remains high.
Methods: We performed retrospective analysis of three sequential prospective cohorts of HIV-infected Ugandan adults presenting with AIDS and meningitis from 2006-2009, 2010-2012 and 2013-2016. Participants were categorized as: 1) unknown HIV status; 2) known HIV+ without ART; 3) known HIV+ with previous ART. We further categorized 2006 and 2013 cohort participants by duration of HIV-status knowledge and of ART receipt.
Results: We screened 1353 persons with suspected meningitis. Cryptococcus was the most common pathogen (63%). Over the decade we observed an absolute increase of 37% in HIV status knowledge and 59% in antecedent ART receipt at screening. 2006 cohort participants were new/recent HIV diagnoses (65%) or known HIV+ but not receiving ART (35%). Many 2013 cohort participants were new/recent HIV diagnoses (34%) and known HIV+ with <1-month ART (20%), but a significant proportion were receiving ART 1-4 months (11%) and >4 months (30%). 4% discontinued ART. From 2010 to 2016, meningitis cases per month increased by 33%.
Conclusions: While improved HIV screening and ART access remain much-needed interventions in resource-limited settings, greater investment in viral suppression and opportunistic infection care among the growing HIV-infected population receiving ART is essential to reducing ongoing AIDS mortality.
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