dc.contributor.author | Amir, Abdallah | |
dc.contributor.author | Saulters, Kacie J. | |
dc.contributor.author | Olum, Sam | |
dc.contributor.author | Pitts, Kelly | |
dc.contributor.author | Parsons, Andrew | |
dc.contributor.author | Churchill, Cristina | |
dc.contributor.author | Taseera, Kabanda | |
dc.contributor.author | Muhindo, Rose | |
dc.contributor.author | Moore, Christopher C. | |
dc.date.accessioned | 2022-05-18T09:30:10Z | |
dc.date.available | 2022-05-18T09:30:10Z | |
dc.date.issued | 2016 | |
dc.identifier.citation | Amir, A., Saulters, K. J., Olum, S., Pitts, K., Parsons, A., Churchill, C., ... & Moore, C. C. (2016). Outcomes of patients with severe sepsis after the first 6 hours of resuscitation at a regional referral hospital in Uganda. Journal of critical care, 33, 78-83. | en_US |
dc.identifier.uri | http://ir.must.ac.ug/xmlui/handle/123456789/1956 | |
dc.description.abstract | Introduction: The optimal resuscitation strategy for patients with severe sepsis in resource-limited settings is unknown. Therefore, we determined the association between intravenous fluids, changes in vital signs and lactate after the first 6 hours of resuscitation from severe sepsis, and in-hospital mortality at a hospital in Uganda.
Materials and methods: We enrolled patients admitted with severe sepsis to Mbarara Regional Referral Hospital and obtained vital signs and point-of-care blood lactate concentration at admission and after 6 hours of resuscitation. We used logistic regression to determine predictors of in-hospital mortality.
Results: We enrolled 218 patients and had 6 hour postresuscitation data for 202 patients. The median (interquartile range) age was 35 (26-50) years, 49% of patients were female, and 57% were HIV infected. The in-hospital mortality was 32% and was associated with admission Glasgow Coma Score (adjusted odds ratio [aOR], 0.749; 95% confidence interval [CI], 0.642-0.875; P b .001), mid-upper arm circumference (aOR, 0.876; 95% CI, 0.797- 0.964; P = .007), and 6-hour systolic blood pressure (aOR, 0.979; 95% CI, 0.963-0.995; P = .009) but not lactate clearance of 10% or greater (aOR, 1.2; 95% CI, 0.46-3.10; P = .73).
Conclusions: In patients with severe sepsis in Uganda, obtundation and wasting were more closely associated with in-hospital mortality than lactate clearance of 10% or greater. | en_US |
dc.description.sponsorship | Pfizer Initiative in International Health and the Center for Global Health at the University of Virginia. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | Journal of Critical Care | en_US |
dc.subject | Severe sepsis | en_US |
dc.subject | Resuscitation | en_US |
dc.subject | Monitoring | en_US |
dc.subject | Mortality | en_US |
dc.subject | Uganda | en_US |
dc.subject | Africa | en_US |
dc.title | Outcomes of patients with severe sepsis after the first 6 hours of resuscitation at a regional referral hospital in Uganda | en_US |
dc.type | Article | en_US |