dc.contributor.author | Tenywa, Mercy Gladys | |
dc.contributor.author | Agaba, Amon Ganafa | |
dc.contributor.author | Ajayi, Clement Olusoji | |
dc.contributor.author | Tolo, Casim Umba | |
dc.contributor.author | Katuura, Esther | |
dc.date.accessioned | 2022-07-28T08:34:33Z | |
dc.date.available | 2022-07-28T08:34:33Z | |
dc.date.issued | 2022-04 | |
dc.identifier.citation | Mercy, G. T., Amon, G. A., Clement, O. A., Casim, U. T., & Esther, K. (2022). Analgesic, anti-inflammatory and oxytocic activities of Dracaena steudneri Engl. stem bark aqueous extract in Wistar rats. Journal of Medicinal Plants Research, 16(4), 148-153. | en_US |
dc.identifier.uri | http://ir.must.ac.ug/xmlui/handle/123456789/2287 | |
dc.description.abstract | Dracaena steudneri Engl. (Dracaenaceae) is a medicinal plant that is used in labour by traditional birth attendants to induce labour, relieve pain and treat various diseases; albeit no documentation. This study determined the analgesic, anti-inflammatory and oxytocic effects of the D. steudneri stem bark aqueous extract. D. steudneri stem bark was collected, authenticated, oven-dried at 45ºC for 48 h, pulverized and extracted using the decoction method. The analgesic effect of the aqueous extract was determined using the acetic acid writhing test, anti-inflammatory activity was determined using paw oedema method while oxytocic activity was determined using abortion and other standard test procedures and were tested at 12.1 24.1 and 48.2 mg/kg. The results of the analgesic study showed that the extract reduced the number of abdominal writhing between 53.51 and 92.40% at 6.02 and 48.2 mg/kg dose, respectively while the standard drug showed a reduction of 36.58% at 10 mg/kg. The anti-inflammatory results showed percentage inhibition of 18.6% (2 h), 22% (2 h) and 18.9% (6 h) at 12.1, 24.1 and 48.2 mg/kg, respectively. The in vivo oxytocic activity showed average time taken for the rats to deliver was between 20.63 h at lowest dose (12.1 mg/kg) and 8.25 h at highest dose (48.0 mg/kg) while Oxytocin the reference drug exhibited, 22 h as the average time taken for delivery | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | Journal of Medicinal Plants Research | en_US |
dc.subject | Analgesic | en_US |
dc.subject | Oxytocic | en_US |
dc.subject | Anti-inflammatory and obstetrics | en_US |
dc.title | Analgesic, anti-inflammatory and oxytocic activities of Dracaena steudneri Engl. stem bark aqueous extract in Wistar rats | en_US |
dc.type | Article | en_US |