dc.contributor.author | Boyce, Ross M. | |
dc.contributor.author | Collins, Matthew | |
dc.contributor.author | Muhindo, Rabbison | |
dc.contributor.author | Nakakande, Regina | |
dc.contributor.author | Ciccone, Emily J. | |
dc.contributor.author | Grounds, Samantha | |
dc.contributor.author | Espinoza, Daniel | |
dc.contributor.author | Zhu, Yerun | |
dc.contributor.author | Matte, Michael | |
dc.contributor.author | Ntaro, Moses | |
dc.contributor.author | Nyehangane, Dan | |
dc.contributor.author | Juliano, Jonathan J. | |
dc.contributor.author | Mulogo, Edgar Mugema | |
dc.date.accessioned | 2022-09-01T07:17:26Z | |
dc.date.available | 2022-09-01T07:17:26Z | |
dc.date.issued | 2020 | |
dc.identifier.citation | Boyce, R. M., Collins, M., Muhindo, R., Nakakande, R., Ciccone, E. J., Grounds, S., ... & Mulogo, E. M. (2020). Dengue in western Uganda: A prospective cohort of children presenting with undifferentiated febrile illness. BMC infectious diseases, 20(1), 1-10. | en_US |
dc.identifier.uri | http://ir.must.ac.ug/xmlui/handle/123456789/2447 | |
dc.description.abstract | Background: The spatial distribution and burden of dengue in sub-Saharan Africa remains highly uncertain, despite high levels of ecological suitability. The goal of this study was to describe the epidemiology of dengue among a cohort of febrile children presenting to outpatient facilities located in areas of western Uganda with differing levels of urbanicity and malaria transmission intensity.
Methods: Eligible children were first screened for malaria using rapid diagnostic tests. Children with a negative malaria result were tested for dengue using a combination NS1/IgM/IgG rapid test (SD Bioline Dengue Duo). Confirmatory testing by RT-PCR was performed in a subset of participants. Antigen-capture ELISA was performed to estimate sero-prevalence.
Results: Only 6 of 1416 (0.42%) children had a positive dengue rapid test, while none of the RT-PCR results were positive. ELISA testing demonstrated reactive IgG antibodies in 28 (2.2%) participants with the highest prevalence seen at the urban site in Mbarara (19 of 392, 4.9%, p < 0.001).
Conclusions: Overall, these findings suggest that dengue, while present, is an uncommon cause of non-malarial, pediatric febrile illness in western Uganda. Further investigation into the ecological factors that sustain low-level transmission in urban settings are urgently needed to reduce the risk of epidemics | en_US |
dc.description.sponsorship | Takeda Vaccines | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | BMC infectious diseases | en_US |
dc.subject | Dengue | en_US |
dc.subject | Fever | en_US |
dc.subject | Arbovirus | en_US |
dc.subject | Epidemiology | en_US |
dc.subject | Uganda | en_US |
dc.title | Dengue in Western Uganda: a prospective cohort of children presenting with undifferentiated febrile illnes | en_US |
dc.type | Article | en_US |