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dc.contributor.authorMbalibulha, Yona
dc.contributor.authorNatukunda, Bernard
dc.contributor.authorOkwi, Andrew Livex
dc.contributor.authorKalyango, Joan N
dc.contributor.authorIsaac, Kajja
dc.contributor.authorOnonge, Sam
dc.date.accessioned2023-02-24T08:13:21Z
dc.date.available2023-02-24T08:13:21Z
dc.date.issued2022
dc.identifier.citationMbalibulha, Y., Natukunda, B., Okwi, A. L., Kalyango, J. N., Isaac, K., & Ononge, S. (2022). Alloimmunization to Rh Antigen (D, C, E, C, E) Among Pregnant Women Attending Antenatal Care in South Western Uganda. Journal of Blood Medicine, 747-752.en_US
dc.identifier.urihttp://ir.must.ac.ug/xmlui/handle/123456789/2780
dc.description.abstractIntroduction: Maternal red cell alloimmunization to Rh antigen in pregnant women occurs when the immune system is sensitized by foreign red blood cell surface antigens, in this case fetal red blood cells, inducing an immune response. Various antigens of blood group systems may cause alloimmunization, especially the Rh, Kel, Fy, JK, and MNS systems. This study aimed to determine alloimmunization to the different frequencies of Rh antigen among pregnant women in South Western Uganda. Methods: A total of 1369 pregnant women consented and were recruited into a cross-sectional study during their regular antenatal visits during the period August 2020 to July 2021. Samples (4 mL) of anticoagulated and coagulated blood were obtained, and Rh blood grouping including Rh antigen and the indirect antiglobulin test (IAT) was carried out using the agglutination technology of the LISS ID-Card technique in the Ortho Biovue ID-Micro Typing System. Results: Out of 1369 participants recruited to the study, 78 (5.7%) were D−, 1291 were D+, and 134 (9.8%) had alloantibodies. Among those with alloantibodies, 115 (85.8%) were D+ and 19 (14.2%) D−. The percentage alloimmunization according to the Rh antigens was highest in e (9.72%), c (2.48%), C (2.34%) and E (0.94%) antigens. With the ABO system, alloimmunization was highest in blood group B (10.7%), followed by A (10.6%), O (9.2%) and then AB (7.1%). Alloimmunization was more prevalent in D− (24%) than in D+ participants (8.9%). Rhesus antigen e was the most prevalent antigen (99.8%), followed by c. The alloimmunization rate of 9.8% among these participants is high, and appears in both D+ and D− women. The other Rhesus antigens are seen to cause alloimmunization, with antigen e causing the highest prevalence. In conclusion, there is a need to identify antibodies and study the outcome for clinical significance, especially in D+ women, to facilitate proper pregnancy management.en_US
dc.description.sponsorshipSwedish International Development Cooperation Agency (Sida) and Makerere University under Sida contribution No 51180060en_US
dc.language.isoen_USen_US
dc.publisherJournal of Blood Medicineen_US
dc.subjectRh alloimmunizationen_US
dc.subjectRh antigensen_US
dc.subjectHemolytic disease of the fetus and newbornen_US
dc.subjectPregnant womenen_US
dc.subjectWestern Ugandaen_US
dc.titleAlloimmunization to Rh Antigen (D, C, E, C, E) Among Pregnant Women Attending Antenatal Care in South Western Ugandaen_US
dc.typeArticleen_US


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