GC-FID and GC-MS profiling and in vitro antidiabetic and antioxidant activities of Chenopodium ambrosioides L.
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Date
2023Author
Kasali, Félicien Mushagalusa
Ali, Muhammad Shaiq
Kadima, Justin Ntokamunda
Tusiimire, Jonans
Lateef, Mehreen
Omole, Ruth Anyango
Tabakam, Gaétan Tchangou
Agaba, Amon Ganafa
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Chenopodium ambrosioides is widely used in traditional medicines to manage several health conditions. This study aimed to investigate the chemical composition of the n-hexane fraction and the in vitro antidiabetic and antioxidant properties of C. ambrosioides L. The chemical composition was determined using Gas Chromatography-Flame Ionization Detection and Gas Chromatography-Mass Spectrometry. In vitro evaluations were assessed by evaluating the inhibitory potentials on the activities of _-glucosidase and antioxidant. A total of 58 phytochemicals were identified belonging to 11 classes of substances, of which aliphatic hydrocarbons (38.25%), diterpenes (20.54%), esters (16.33%), triterpenes (11.91%), diverse functional groups (3.74%), aromatic hydrocarbons (2.64%), sesquiterpenes (2.31%), alcohols (1.41%), ketones (0.29%), monoterpenes (0.16%), and fatty acids (0.14%). The major compounds were heptacosane (30.48%) (46), phytol (20.94) (35), and squalene (11.07%) (56). The methanol extract and its fractions showed moderate _-glucosidase activity, but their IC50 values were lower than the positive control 1-deoxynojirimycin. However, the methanol and methanol-water fractions exhibited more scavenging activity on 2,2-diphenyl-1-picrylhydrazyl with IC50 values similar to butylated hydroxyanisole (BHA). The plant is rich in various phytoconstituents, and it’s _-glucosidase and antioxidant status may justify its use in traditional medicine, especially for preventing complications of diabetes.
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