Research Articles: Recent submissions
Now showing items 21-40 of 111
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Blood Pressure Variability and Shifting in Clinical Outcome Amongst Stroke Patients in South western Uganda
(East African Journal of Neurological Sciences, 2024)Background: Higher blood pressure variability is associated with shifting towards worse outcome among stroke patients. Methods: We conducted a prospective cohort study of CT head confirmed ischemic and hemorrhagic stroke ... -
Trichomoniasis and associated factors in Rugarama hospital, a peri-urban health facility in south western Uganda
(Journal of Protozoology Research, 2024)Trichomoniasis is one of the neglected sexually transmitted infections caused by Trichomonas vaginalis. A cross-sectional study to determine the prevalence and factors associated with trichomoniasis among patients seeking ... -
The Tuberculosis Sentinel Research Network (TB- SRN) of the International epidemiology Databases to Evaluate AIDS (IeDEA): protocol for a prospective cohort study in Africa, Southeast Asia and Latin America
(MJ open, 2024)Introduction: Tuberculosis (TB) is a leading infectious cause of death globally. It is the most common opportunistic infection in people living with HIV, and the most common cause of their morbidity and mortality. Following ... -
The Role of Antioxidants in Improving Pregnancy Outcomes
(IAA Journal of Applied Sciences, 2024)Pregnancy is a physiologically demanding phase marked by profound changes that elevate oxidative stress levels, posing potential risks to maternal and fetal health. Oxidative stress, resulting from an imbalance between ... -
Dyslipidemia: prevalence and association with precancerous and cancerous lesions of the cervix; a pilot stud
(Lipids in Health and Disease, 2024)Background: In Sub-Saharan Africa, the prevalence of dyslipidemia is on the rise, with studies showing dyslipidemia as a contributing factor to the progression of premalignant lesions to cervical cancer. In Uganda, cervical ... -
Limited threat of Plasmodium falciparum pfhrp2 and pfhrp3 gene deletion to the utility of HRP2-based malaria RDTs in Northern Uganda
(Malaria Journal, 2024)Background: Rapid diagnostic tests (RDTs) that detect Plasmodium falciparum histidine-rich protein-2 (PfHRP2) are exclusively deployed in Uganda, but deletion of the pfhrp2/3 target gene threatens their usefulness as malaria ... -
Anemia in HIV Patients Attending Highly Active Antiretroviral Therapy Clinic at Hoima Regional Referral Hospital: Prevalence, Morphological Classification, and Associated Factor
(HIV/AIDS - Research and Palliative Care, 2023)Purpose: To determine the prevalence of anemia, the morphological classification and to assess the factors associated with anemia among HIV patients attending Highly Active Antiretroviral Therapy (HAART) clinic at Hoima ... -
Prospective evaluation of the impact of potent antiretroviral therapy on the incidence of Kaposi’s Sarcoma in East Africa: findings from the International Epidemiologic Databases to Evaluate AIDS (IeDEA) Consortium
(Infectious Agents and Cancer, 2012)Prior to the rollout of potent antiretroviral therapy (ART), Kaposi’s sarcoma (KS) was the most commonly reported malignancy in many resource-limited settings, such as most of sub-Saharan Africa. In resource-replete settings ... -
Phosphatidylethanol confirmed alcohol use among ART-naïve HIV-infected persons who denied consumption in rural Uganda
(AIDS care, 2017)Under-reporting of alcohol use by HIV-infected patients could adversely impact clinical care. This study examined factors associated with under-reporting of alcohol consumption by patients who denied alcohol use in clinical ... -
Iron Deficiency Anaemia in Children
(International Research in Medical and Health Sciences, 2023)Two-thirds of anemia in children worldwide, of which IDA accounts for 20 to 25% of cases, are caused by iron deficiency, which is a significant global health burden. Despite treatment, unfortunately, IDA can have ... -
Prevalence of Gestational Diabetes Mellitus and Predisposing Factors among Pregnant Women Attending Antenatal Clinic at Kawolo General Hospital. A Cross-sectional Descriptive Study.
(Student's Journal of Health Research Africa, 2022)Background: Globally, the prevalence of Hyperglycemia first detected in pregnancy (Gestational Diabetes Mellitus) varies from 1 - 28 %. 16.2 % of women have some form of hyperglycemia, of which GDM is about 85.1%. 87.6% ... -
Antioxidants in the Management of Sickle Cell Anaemia: An Area to Be Exploited for the Wellbeing of the Patients
(International Research in Medical and Health Sciences, 2023)Sickle cell disease (SCD), also known as sickle cell anemia, is an often serious autosomal recessive disorder that occurs when both parents pass the defective gene to their children. When oxygen pressure is low, the biconcave ... -
A Cross-Sectional Study to Determine Urinary Tract Infections and Antibiotic Susceptibility Patterns among Pregnant Women attending Antenatal Clinic at Kawempe National Referral Hospital, Uganda.
(Student's Journal of Health Research Africa, 2022)Background: Urinary Tract Infection (UTI) is a disease of urinary system. This type of infection involves urethritis, pyro nephritis or cystitis. Symptoms can be pelvic pain, increased urge to urinate, pain on passing out ... -
Physico-Chemical and Microbiological Safety of Water Utilized in the Medical Cell, Mbarara City, Southwestern Uganda, a Cross-Sectional Study
(Student's Journal of Health Research Africa, 2023)Introduction: Safe and readily available water is very vital for public health functions whether it is used for drink- ing, food production, washings, or recreation purposes. This study assessed the physical properties ... -
Investigating Metabolic and Molecular Ecological Evolution of Opportunistic Pulmonary Fungal Coinfections: Protocol for a Laboratory-Based Cross-Sectional Study
(JMIR Research Protocols, 2023)Background: Fungal-bacterial cocolonization and coinfections pose an emerging challenge among patients suspected of having pulmonary tuberculosis (PTB); however, the underlying pathogenic mechanisms and microbiome interactions ... -
FKBP11 upregulation promotes proliferation and migration in hepatocellular carcinoma
(Cancer Biomarkers, 2023)Background: Hepatocellular carcinoma (HCC) is one of the leading causes of cancer related deaths world over. Early\ diagnosis and effective treatment monitoring significantly improves patients’ outcomes. FKBP11 gene is ... -
Beyond undetectable: Modeling the clinical benefit of improved antiretroviral adherence in persons with HIV with virologic suppression
(In Open Forum Infectious Diseases, 2023)Background: Incomplete antiretroviral therapy (ART) adherence has been linked to deleterious immunologic, inflammatory, and clinical consequences, even among virally suppressed (<50 copies/mL) persons with HIV (PWH). The ... -
Malaria Prevalence and Associated Factors in Children Under Five Years in Dokolo District, Northern Uganda: A Community-Based Cross-Sectional Study
(Annals of Epidemiology and Public Health, 2023)Introduction: Malaria remains a major public health problem affecting children <5 years because of the weak im¬mune system. Uganda set targets to control and eliminate malaria with interventions of most at-risk groups; ... -
Association between obesity and cervical intraepithelial neoplasia: results from a case control study in south western Uganda
(BMC Women's Health, 2023)Background: Though obesity has been said to be associated with a number of malignancies including cervical cancer, its association with cervical intraepithelial neoplasia (CIN) is still a contentious issue. This study was ... -
Comparison of automated determination of phosphatidylethanol (PEth) in dried blood spots (DBS) with previous manual processing and testing
(Alcohol, 2022)Phosphatidylethanol (PEth) is a sensitive and specific biomarker of alcohol consumption in the prior 2–3 weeks. Standard, manual PEth testing using dried blood spots (DBS) is a multi-step time-consuming process. A novel, ...