Faculty of Medicine: Recent submissions
Now showing items 121-140 of 2030
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Carbapenem‑resistant Enterobacteriaceae in the livestock, humans and environmental samples around the globe: a systematic review and meta‑analysis
(Scientific Reports, 2024)Carbapenem‑resistant Enterobacteriaceae (CRE) have diminished treatment options causing serious morbidities and mortalities. This systematic review and meta‑analysis assessed the prevalence and associated factors of ... -
Association between dyslipidemia and cervical intraepithelial neoplasia: A case-control study in south-western Uganda
(African Journal of Laboratory Medicine, 2024)Background: Altered lipid levels may be associated with the development of a number of malignancies, including cancer of the cervix. However, there is limited understanding of this relationship in the rural Ugandan context. ... -
Gut-brain axis: A cutting-edge approach to target neurological disorders and potential synbiotic application
(Heliyon, 2024)The microbiota-gut-brain axis (MGBA) represents a sophisticated communication network between the brain and the gut, involving immunological, endocrinological, and neural mediators. This bidirectional interaction is ... -
Point-of-care potentials of lateral flow-based field screening for Mycoplasma bovis infections: a literature review
(Biology Methods and Protocols, 2024)Point-of-care (POC) field screening for tools for Mycoplasma bovis (M. bovis) is still lacking due to the requirement for a simple, robust field-applicable test that does not entail specialized laboratory equipment. In ... -
Primary Healthcare Workers’ Awareness of Acute Rheumatic Fever & Rheumatic Heart Disease: A Study in Public Health Facilities in South Western Uganda
(Pediatric Health, Medicine and Therapeutics, 2024)Introduction: Timely identification and treatment of a streptococcal throat infection prevents acute rheumatic fever (ARF) and its progression to Rheumatic Heart Disease (RHD). However, children in developing countries ... -
Sequence variation does not confound the measurement of plasma PfHRP2 concentration in African children presenting with severe malaria
(Malaria journal, 2012)Background: Plasmodium falciparum histidine-rich protein PFHRP2 measurement is used widely for diagnosis, and more recently for severity assessment in falciparum malaria. The Pfhrp2 gene is highly polymorphic, with deletion ... -
Evaluation of OMNIgene Sputum and Ethanol Reagent for Preservation of Sputum Prior to Xpert and Culture Testing in Uganda
(Journal of Clinical Microbiology, 2019)Xpert MTB/RIF (Xpert) and culture are the most reliable methods for tuberculosis diagnosis but are still poorly accessible in many low-resource countries. We aimed to assess the effects of OMNIgene Sputum (OM-S) and ethanol ... -
Effect of Empiric Anti–Mycobacterium tuberculosis Therapy on Survival Among Human Immunodeficiency Virus–Infected Adults Admitted With Sepsis to a Regional Referral Hospital in Uganda
(In Open Forum Infectious Diseases, 2019)Background: Mycobacterium tuberculosis is the leading cause of bloodstream infection among human immunodeficiency virus (HIV)–infected patients with sepsis in sub-Saharan Africa and is associated with high mortality ... -
Factors associated with HIV testing among traditional healers and their clients in rural Uganda: Results from a cross-sectional study
(International journal of STD & AIDS, 2021)Uptake of HIV testing is suboptimal in Uganda, particularly in rural communities. Reaching UNAIDS95-95-95 goals requires strategies to increase HIV testing among hard-to-reach populations. This cross-sectional study sought ... -
Early biting and insecticide resistance in the malaria vector Anopheles might compromise the effectiveness of vector control intervention in Southwestern Uganda
(Malaria journal, 2015)Background: Southwestern Uganda has high malaria heterogeneity despite moderate vector control and other interventions. Moreover, the early biting transmission and increased resistance to insecticides might compromise ... -
In‑vivo and in‑silico studies revealed the molecular mechanisms of Colocasia esculenta phenolics as novel chemotherapy against benign prostatic hyperplasia via inhibition of 5α‑reductase and α1‑adrenoceptor
(In Silico Pharmacology, 2023)Benign Prostatic Hyperplasia (BPH) is a major cause of lower urinary tract infections and erectile dysfunction thus a major contributor to lowering the quality of life among older men. In this study, we investigated the ... -
Diagnosing Severe Falciparum Malaria in Parasitaemic African Children- a Prospective Evaluation of Plasma Pf HRP2 Measurement
(PLOS Medicine, 2012)Background: In African children, distinguishing severe falciparum malaria from other severe febrile illnesses with coincidental Plasmodium falciparum parasitaemia is a major challenge. P. falciparum histidine-rich protein ... -
Carriage prevalence and serotype distribution of Streptococcus pneumoniae prior to 10-valent pneumococcal vaccine introduction- population-based cross-sectional study in South Western Uganda, 2014
(Vaccine, 2017)Background: Information on Streptococcus pneumoniae nasopharyngeal (NP) carriage before the pneumococcal conjugate vaccine (PCV) introduction is essential to monitor impact. The 10-valent PCV (PCV10) was officially introduced ... -
Predictors of delayed culture conversion among Ugandan patients
(BMC infectious diseases, 2017)Background: Estimates of month-2 culture conversion, a proxy indicator of tuberculosis (TB) treatment efficacy in phase-2 trials can vary by culture-type and geographically with lower rates reported among African sites. ... -
Prospective cohort study of the feasibility and yield of household child tuberculosis contact screening in Uganda
(The International Journal of Tuberculosis and Lung Disease, 2017)Setting: Screening and isoniazid preventive therapy (IPT) of child contacts of tuberculosis (TB) patients is poorly implemented in resource-limited countries, in part due to difficulties in TB diagnosis in children. ... -
Inhaled Nitric Oxide and Cerebral Malaria: Basis of a Strategy for Buying Time for Pharmacotherapy
(The Pediatric Infectious Disease Journal, 2012)There are approximately 225–600 million new malaria infections worldwide annually, with severe and cerebral malaria representing major causes of death internationally. The role of nitric oxide (NO) in the host response in ... -
Artesunate versus quinine in the treatment of severe falciparum malaria in African children (AQUAMAT): an open-label, randomised trial
(The Lancet, 2010)Background: Severe malaria is a major cause of childhood death and often the main reason for paediatric hospital admission in sub-Saharan Africa. Quinine is still the established treatment of choice, although evidence from ... -
Male Gender is independently associated with pulmonary tuberculosis among sputum and non-sputum producers people with presumptive tuberculosis in Southwestern Uganda
(BMC infectious diseases, 2014)Background: Little is known about the association between gender and risk of TB infection. We sought to assess the impact of gender on TB prevalence among people with presumptive tuberculosis at a regional referral hospital ... -
“Everything is a Mess”: How COVID‑19 is Impacting Engagement with HIV Testing Services in Rural Southwestern Uganda
(AIDS and Behavior, 2020)In southwestern Uganda, where HIV prevalence among sexually active adults is ~ 7% [1], we have been conducting longitudinal research to improve uptake of HIV testing among communities who utilize informal health providers, ... -
Diagnostic Accuracy of the Small Membrane Filtration Method for Diagnosis of Pulmonary Tuberculosis in a High-HIV-Prevalence Setting
(Journal of clinical microbiology, 2016)Sputumacid-fastbacilli (AFB) smear microscopy has suboptimal sensitivity but remains the most commonly used laboratory test to diagnose pulmonary tuberculosis (TB). We prospectively evaluated the small membrane filtration ...