Faculty of Medicine: Recent submissions
Now showing items 161-180 of 2030
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Distinct cytokine profiles in late pregnancy in Ugandan people with HIV
(Scientific Reports, 2024)During pregnancy, multiple immune regulatory mechanisms establish an immune‑tolerant environment for the allogeneic fetus, including cellular signals called cytokines that modify immune responses. However, the impact of ... -
Customization and acceptability of the WHO labor care guide to improve labor monitoring among health workers in Uganda. An iterative development, mixed method study
(PLOS Global Public Health, 2024)Cognisant of persistently high maternal and perinatal mortality rates, WHO called for adoption and evaluation of new adaptable and context-specific solutions to improve labor monitoring and health outcomes. We aimed at ... -
Association between clinical and sonographic patterns of major peripheral arterial occlusion among patients presenting with lower limb dry gangrene at a single center in Western Uganda
(Tungs' Medical Journal, 2024-05-13)Background: Dry gangrene occurs due to a reduced blood supply in body parts, resulting in gradual necrosis. It is among the leading indications for lower limb amputation; however, in situations where timely access of ... -
“We are never taught anything about the elderly.” Establishing the gap in elderly health care competencies in nursing education in Uganda
(BMC nursing, 2022)Background: Nurses contribute the largest portion of Uganda’s health workforce providing care to individuals of all ages and communities. However, despite the growing number of the elderly population in Uganda with improved ... -
The Role of Mass Media Campaigns in Improving Adherence to Antiretroviral Therapy Among Adolescents Living with HIV in Southwestern Uganda
(HIV/AIDS, 2022)Background: Globally, about 1.8 million adolescents between the ages of 10 and 19 were living with HIV by close of 2021, of these, about 1.5 million were living in sub-Saharan Africa. This study explored the influence of ... -
Legacy of COVID-19 Innovations: Strengthening African Primary Health Care through Pandemic Innovations
(Sustainability, 2023)The COVID-19 pandemic led to a global surge of health care innovations aimed at curbing the pandemic. Some of the innovations were newly developed whereas others were modifications of existing technologies to suit the ... -
Evidence-Supported Interventions for Reducing Secondary Stroke Risk in Sub-Saharan Africa: A Systematic Review
(Neuropsychiatric Disease and Treatment, 2023)The study set out to perform a systematic literature review of evidence-based interventions that target the reduction of secondary stroke risk in Africa. The review analyzed longitudinal intervention studies conducted in ... -
Burden of heart diseases in children attending cardiology clinic in a regional referral hospital in Uganda
(International Clinical Pathology Journal, 2017)Introduction: Patterns and prevalence of heart diseases are different between the high income countries and low income countries. Acquired heart diseases like RHD, cardiomyopathies, pericarditis are still a public health ... -
Adverse maternal outcomes and associated factors among mothers of advanced age delivering at a tertiary hospital, southwestern Uganda: a cross-sectional study
(BMC Pregnancy and Childbirth, 2024)Background: Mothers of advanced age, defined as pregnant women aged ≥ 35 years at the time of giving birth, are traditionally known to be associated with increased risks of adverse maternal outcomes. We determined the ... -
A cross-sectional study of ERG expression and the relationship with clinicopathological features of Prostate cancer in Southwestern Uganda
(Diagnostic Pathology, 2024)Background: Prostate cancer is the leading cause of cancer-related death and the second most commonly diagnosed cancer among men in Uganda and most countries in Sub-Saharan Africa (SSA). The TMPRSS2-ERG fusion gene is the ... -
Screening for Glucose-6-Phosphate Dehydrogenase Deficiency Using Three Detection Methods: A Cross-Sectional Survey in Southwestern Uganda
(The American Society of Tropical Medicine and Hygiene, 2016)Despite the potential benefit of primaquine in reducing Plasmodium falciparum transmission and radical cure of Plasmodium vivax and Plasmodium ovale infections, concerns over risk of hemolytic toxicity in individuals with ... -
Reducing stroke burden through a targeted self-management intervention for reducing stroke risk factors in high-risk Ugandans: A protocol for a randomized controlled trial
(Plos one, 2021)Introduction: Stroke burden is rapidly increasing globally. Modifiable risk factors offer an opportunity to intervene, and targeting hypertension is a key actionable target for stroke risk reduction in sub-Saharan Africa. ... -
Newborn care knowledge and practices among care givers of newborns and young infants attending a regional referral hospital in Southwestern Uganda
(PloS one, 2024-05-07)A child born in developing countries has a 10 times higher mortality risk compared to one born in developed countries. Uganda still struggles with a high neonatal mortality rate at 27/ 1000 live births. Majority of these ... -
Iron status of pregnant women at first antenatal booking in Mbarara University Teaching Hospital
(Tropical doctor, 1999)An assessment of iron status was made on 96 pregnant women and 29 non-pregnant, non-lactating menstruat- ing women of comparable age group as controls. Anaemia (haemoglobin < 110 g/l) was present in 84.4% of the pregnant ... -
Estimating prognosis for traumatic brain injury patients in a low-resource setting: how do providers compare to the CRASH risk calculator?
(Journal of neurosurgery, 2020)Objective: Traumatic brain injury (TBI), a burgeoning global health concern, is one condition that could benefit from prognostic modeling. Risk stratification of TBI patients on presentation to a health facility can support ... -
Implementation of a safer conception programme for HIV- affected men and women in rural Uganda
(Global Public Health, 2024)We integrated safer conception care into a Ugandan HIV clinic. People with HIV (PWH), or partnered with a PWH, and desiring children were eligible for the Healthy Families Clinic Program. Clients completed quarterly safer ... -
Genetic diversity in Plasmodium falciparum merozoite surface protein 1 and 2 coding genes and its implications in malaria epidemiology: a review of published studies from 1997–2007
(Journal of Vector Borne Diseases, 2009-04)A major characteristic of human malaria parasites is their genetic diversity and an increasing number of studies have been reported on the epidemiology of Plasmodium falciparum, mainly focusing on the polymorphism of ... -
Evaluation of the Deki Reader™, an automated RDT reader and data management device, in a household survey setting in low malaria endemic southwestern Uganda
(Malaria journal, 2017)Background: Early diagnosis of suspected malaria cases with a rapid diagnostic test (RDT) has been shown to be an effective malaria control tool used in many resource‑constrained settings. However, poor quality control and ... -
Appetite Suppressing Activity of Rumex Usambarensis Leaf and Stem Aqueous Extract in Wistar Albino Female Rats: an in vivo Experimental Study
(Journal of Experimental Pharmacology, 2024)Background: The burden of obesity and overweight associated morbidity and mortality is increasing in epidemic proportions worldwide. Suppression of appetite is one of the mechanisms that has been shown to reduce weight. ... -
Antimicrobial treatment practices among Ugandan children with suspicion of central nervous system infection
(PLoS One, 2018)Acute central nervous system (CNS) infections in children in sub-Saharan Africa are often fatal. Potential contributors include late presentation, limited diagnostic capacity and inadequate treatment. A more nuanced ...