Diversity of Mycobacterium tuberculosis Complex Lineages Associated with Pulmonary Tuberculosis in Southwestern, Uganda
dc.contributor.author | Micheni, Lisa Nkatha | |
dc.contributor.author | Kassaza, Kennedy | |
dc.contributor.author | Kinyi, Hellen | |
dc.contributor.author | Ntulume, Ibrahim | |
dc.contributor.author | Bazira, Joel | |
dc.date.accessioned | 2021-11-19T07:31:37Z | |
dc.date.available | 2021-11-19T07:31:37Z | |
dc.date.issued | 2021-06-28 | |
dc.identifier.citation | Micheni, L. N., Kassaza, K., Kinyi, H., Ntulume, I., & Bazira, J. (2021). Diversity of Mycobacterium tuberculosis Complex Lineages Associated with Pulmonary Tuberculosis in Southwestern, Uganda. Tuberculosis research and treatment, 2021. | en_US |
dc.identifier.uri | http://ir.must.ac.ug/xmlui/handle/123456789/939 | |
dc.description.abstract | Uganda is among the 22 countries in the world with a high burden of tuberculosis. The southwestern region of the country has consistently registered a high TB/HIV incidence rate. This study is aimed at characterizing the Mycobacterium tuberculosis complex (MTBC) genotypic diversity in southwestern Uganda. A total of 283 sputum samples from patients with pulmonary tuberculosis were genotyped using specific single nucleotide polymorphism markers for lineages 3 and 4. Most of the patients were males with a mean age of 34. The lineage 4 Ugandan family was found to be the most dominant strains accounting for 59.7% of all cases followed by lineage 3 at 15.2%. The lineage 4 non-Ugandan family accounted for 14.5% of all cases while 4.2% showed amplification for both lineage 4 and lineage 3. Eighteen samples (6.4%) of the strains remained unclassified since they could not be matched to any lineage based on the genotyping technique used. This study demonstrates that a wide diversity of strains is causing pulmonary tuberculosis in this region with those belonging to the lineage 4 Ugandan family being more predominant. However, to confirm this, further studies using more discriminative genotyping methods are necessary | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | Hindawi | en_US |
dc.title | Diversity of Mycobacterium tuberculosis Complex Lineages Associated with Pulmonary Tuberculosis in Southwestern, Uganda | en_US |
dc.type | Article | en_US |
Files in this item
This item appears in the following Collection(s)
-
Research Articles [91]
These are different research articles about different Scholars as far as physics is concerned.