Differences in Immunologic Factors Among Patients Presenting with Altered Mental Status During Cryptococcal Meningitis

Simple item page
dc.contributor.authorLofgren, Sarah
dc.contributor.authorHullsiek, Kathy H.
dc.contributor.authorMorawski, Bozena M.
dc.contributor.authorNabeta, Henry W.
dc.contributor.authorKiggundu, Reuben
dc.contributor.authorTaseera, Kabanda
dc.contributor.authorMusubire, Abdu
dc.contributor.authorSchutz, Charlotte
dc.contributor.authorAbassi, Mahsa
dc.contributor.authorBahr, Nathan C.
dc.contributor.authorTugume, Lillian
dc.contributor.authorMuzoora, Conrad
dc.contributor.authorWilliams, Darlisha A.
dc.contributor.authorRolfes, Melissa A.
dc.contributor.authorVelamakanni, Sruti S.
dc.contributor.authorRajasingham, Radha
dc.contributor.authorMeintjes, Graeme
dc.contributor.authorRhein, Joshua
dc.contributor.authorMeya, David B.
dc.contributor.authorBoulware, David R.
dc.date.accessioned2022-02-08T10:09:43Z
dc.date.available2022-02-08T10:09:43Z
dc.date.issued2017-01
dc.description.abstractAltered mental status in cryptococcal meningitis results in poorer survival, but underlying causes of altered mentation are poorly understood. Within two clinical trials, we assessed risk factors for altered mental status (GCS score<15) considering baseline clinical characteristics, CSF cytokines/chemokines, and antiretroviral therapy. Among 326 enrolled participants, 97 (30%) had GCS<15 and these patients had lower median CSF cryptococcal antigen titers (P = .042) and CCL2 (P = .005) but higher opening pressures (320 vs. 269 mm H2O; P = .016), IL-10 (P = .044), and CCL3 (P = .008) compared with persons with GCS=15. Altered mental status may be associated with host immune response rather than Cryptococcus burdenen_US
dc.description.sponsorshipNational Institute of Neurologic Diseases and Stroke and the Fogarty International Center (Grants R01NS086312 and R25TW009345) and by the National Institute of Allergy and Infectious Diseases (grants U01AI089244 and T32AI055433).en_US
dc.identifier.citationLofgren, S., Hullsiek, K. H., Morawski, B. M., Nabeta, H. W., Kiggundu, R., Taseera, K., ... & COAT and ASTRO-CM Trial Teams. (2017). Differences in immunologic factors among patients presenting with altered mental status during cryptococcal meningitis. The Journal of infectious diseases, 215(5), 693-697.en_US
dc.identifier.urihttp://ir.must.ac.ug/handle/123456789/1431
dc.language.isoen_USen_US
dc.publisherThe Journal of Infectious Diseasesen_US
dc.subjectCryptococcal meningitisen_US
dc.subjectHIV; immunologyen_US
dc.subjectAltered mental statusen_US
dc.subjectCytokines.en_US
dc.titleDifferences in Immunologic Factors Among Patients Presenting with Altered Mental Status During Cryptococcal Meningitisen_US
dc.typeArticleen_US

Files

Original bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
Differences in Immunologic Factors among Patients Presenting with Altered Mental Status during Cryptococcal Meningitis.pdf
Size:
151.33 KB
Format:
Adobe Portable Document Format
Description:
Main Article
Download

License bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Research articles