Health-point survey of bacteria urinary tract infections among suspected diabetic patients attending clinics in Bushenyi, Uganda

Abstract

Background: Although Urinary tract infections (UTI) and diabetes are individual public health pandemic, their comorbidities remain a global health dilemma. Regional surveillance holds the key to effective intervention. Objectives: To evaluate the prevalence and antibacterial resistance pattern of bacteria etiological agents of UTI among diabetic patients in the Bushenyi district of Uganda. Methods: In this cross-sectional study, 418 midstream urines from consenting 331 diabetics (230 females and 101 males) and 87 non-diabetic (60 females and 27 males) individuals were collected aseptically and processed using standard microbiological methods. Data generated were tested for statistical significance and scientific relevance. Results: Bacteria UTI was 31.1% prevalent in diabetic and 11.4% in non-diabetics. Diabetic patients yielded: 13.6%, Staphylococcus species, 8.8% E.coli, and 8.6% Klebsiella species. Klebsiella species showed 100% resistance to Erythromycin, 71.4% to Cotrimoxazole, and 92.9% to Ampicillin. Bacteria from diabetic patients remained sensitive to Nitrofurantoin, Ciprofloxacin, Ceftazidime, and Ceftriaxone. Extended Spectrum β-Lactamases were detected in 3.5% of Klebsiella species. Age and sex significantly (p<0.05) influenced diabetic UTI prevalence. Conclusion: Diabetes significantly (p<0.05) influenced the observed (27%) UTI distribution. Resistance to Ampicillin and Cotrimoxazole may affect their use in UTI management. Antibacterial misuse is highly discouraged and Nitrofurantoin remains urinary antiseptic.