Higher baseline CD4 cell count predicts treatment interruptions and persistent viremia in patients initiating ARVs in rural Uganda

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dc.contributor.authorAdakun, Susan A.
dc.contributor.authorSiedner, Mark J.
dc.contributor.authorMuzoora, Conrad
dc.contributor.authorHaberer, Jessica E.
dc.contributor.authorTsai, Alexander C.
dc.contributor.authorHunt, Peter W.
dc.contributor.authorMartin, Jeff N.
dc.contributor.authorBangsberg, David R.
dc.date.accessioned2022-06-14T09:03:20Z
dc.date.available2022-06-14T09:03:20Z
dc.date.issued2013
dc.description.abstractWe examined the association between CD4 cell count and adherence in a cohort of Ugandans initiating ARVs. Outcomes were: a) adherence<90%; b) any treatment interruptions>72 hours; c) number of treatment interruptions; and d) HIV RNA>400 copies/ml. We fit regression models to estimate associations with our exposure of interest, baseline CD4 cell count ≥250 cells/μL (n=60) versus <250 cells/μL (n=413). CD4 cell count≥250 cells/μL was independently associated with increased odds and number of treatment interruptions, and increased odds of persistent viremia. Interventions to support adherence in patients with higher CD4 cell counts should be considered as drug availability to this population increases.en_US
dc.description.sponsorshipU.S. National Institutes of Health R01 MH54907 and P30 AI27763en_US
dc.identifier.citationAdakun, S. A., Siedner, M. J., Muzoora, C., Haberer, J. E., Tsai, A. C., Hunt, P. W., ... & Bangsberg, D. R. (2013). Higher baseline CD4 cell count predicts treatment interruptions and persistent viremia in patients initiating ARVs in rural Uganda. Journal of acquired immune deficiency syndromes (1999), 62(3), 317.en_US
dc.identifier.urihttp://ir.must.ac.ug/handle/123456789/2119
dc.language.isoen_USen_US
dc.publisherJournal of acquired immune deficiency syndromesen_US
dc.subjectAdherenceen_US
dc.subjectTest and Treaten_US
dc.subjectUgandaen_US
dc.subjectHIV/AIDSen_US
dc.subjectAdherence Monitoringen_US
dc.subjectMEMSen_US
dc.titleHigher baseline CD4 cell count predicts treatment interruptions and persistent viremia in patients initiating ARVs in rural Ugandaen_US
dc.typeArticleen_US

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