Point-of-Care Diagnosis and Prognostication of Cryptococcal Meningitis With the Cryptococcal Antigen Lateral Flow Assay on Cerebrospinal Fluid
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Oxford University Press
Abstract
The cryptococcal antigen (CRAG) lateral flow assay (LFA)
had 100% sensitivity and specificity on cerebrospinal fluid
samples. Pretreatment LFA titers correlated with quantitative cultures (R2 = 0.7) and predicted 2- and 10-week mortality. The CRAG LFA is an accurate diagnostic assay for CSF
and should be considered for point-of-care diagnosis of
cryptococcal meningitis.
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Citation
Kabanda, T., Siedner, M. J., Klausner, J. D., Muzoora, C., & Boulware, D. R. (2014). Point-of-care diagnosis and prognostication of cryptococcal meningitis with the cryptococcal antigen lateral flow assay on cerebrospinal fluid. Clinical infectious diseases, 58(1), 113-116.