Department of Internal Medicine: Recent submissions
Now showing items 201-220 of 258
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High acceptability for cell phone text messages to improve communication of laboratory results with HIV-infected patients in rural Uganda: a cross-sectional survey study
(BMC medical informatics and decision making, 2012)Background: Patient-provider communication is a major challenge in resource-limited settings with large catchment areas. Though mobile phone usership increased 20-fold in Africa over the past decade, little is known about ... -
Adherence to HIV antiretroviral therapy among pregnant and postpartum women during the Option B+ era: 12-month cohort study in urban South Africa and rural Uganda
(Journal of the International AIDS Society, 2020)Introduction: We conducted a cohort study to understand patterns of anti-retroviral therapy (ART) adherence during pregnancy, postpartum and non-pregnancy follow-up among women initiating ART in public clinics offering ... -
A Causal Framework for Understanding the Effect of Losses to Follow-up on Epidemiologic Analyses in Clinic-based Cohorts: The Case of HIV-infected Patients on Antiretroviral Therapy in Africa
(American journal of epidemiology, 2012)Although clinic-based cohorts are most representative of the ‘‘real world,’’ they are susceptible to loss to follow-up. Strategies for managing the impact of loss to follow-up are therefore needed to maximize the value of ... -
Cerebrospinal Fluid Culture Positivity and Clinical Outcomes After Amphotericin-Based Induction Therapy for Cryptococcal Meningitis
(Infectious Diseases Society of America., 2015-10-19)Background. Amphotericin-based combination antifungal therapy reduces mortality from human immunode-fificiency virus (HIV)-associated cryptococcal meningitis. However, 40%–50% of individuals have positive cerebrospinal ... -
Blood pressure trajectories and the mediated effects of body mass index and HIV‐related inflammation in a mixed cohort of people with and without HIV in rural Uganda
(Wiley, 2019-06-19)We sought to describe changes in blood pressure and estimate the effect of HIV on blood pressure (BP) over 4 years of observation in a cohort of 155 HIV‐infected adults (≥40 years) on antiretroviral therapy (ART) and 154 ... -
Biomass fuel as a risk factor for esophageal squamous cell carcinoma: a systematic review and meta-analysis
(Environmental Health, 2019-07-01)Background: The link between use of solid biomass fuel (wood, charcoal, coal, dung, and crop residues) for cooking and/or heating and esophageal squamous cell carcinoma (ESCC) is inconclusive. Objective: We systematically ... -
Is Sub-Saharan Africa prepared for COVID-19?
(Tropical Medicine and Health, 2020-04-10)Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes coronavirus disease 2019 (COVID-19), is the latest virus to cause global health panic. Due to the rapidly escalating numbers of new ... -
Association between HIV and blood pressure in adults and role of body weight as a mediator: Cross-sectional study in Uganda
(Journal of Clinical Hypertension, 2017-06)The authors sought to describe the association between human immunodeficiency virus (HIV) and blood pressure (BP) levels, and determined the extent to which this relationship is mediated by body weight in a cross-sectional ... -
Prevalence and glasgow outcome scale score of severe head injury in Mbarara regional referral hospital
(Research Square, 2020)Background: Traumatic brain injury (TBI) is a common cause of death in the Intensive care units and emergency departments with an estimated annual global mortality of 1.5 million people as a result of severe TBI. The ... -
Aggregate Evaluable Organ Dysfunction Predicts In-Hospital Mortality from Sepsis in Uganda
(The American journal of tropical medicine and hygiene, 2011)We evaluated the association between severity of sepsis and in-hospital mortality in 150 patients with nonsurgical sepsis at a regional referral hospital in Uganda. In-hospital mortality occurred in 5 of 52 (9.6%) patients ... -
Population attributable fraction of esophageal squamous cell carcinoma due to smoking and alcohol in Uganda
(BMC Cancer, 2016)Background: Despite the high rates and regional variation of esophageal squamous cell carcinoma (ESCC) in East Africa, the contributions of smoking and alcohol to the ESCC burden in the general population are unknown. ... -
Short course amphotericin B with high dose fluconazole for HIV-associated cryptococcal meningitis
(Journal of Infection, 2012)Summary Objective: To define more rapidly effective initial antifungal regimens sustainable in resource-constrained settings. Methods: Cohort study in SW Uganda: Thirty HIV-seropositive, antiretroviral therapy-na€ıve, ... -
Smoking cessation after engagement in HIV care in rural Uganda
(AIDS care, 2018)People living with HIV (PLWH) are more likely to smoke compared to HIV-uninfected counterparts, but little is known about smoking behaviors in sub-Saharan Africa. To address this gap in knowledge, we characterized smoking ... -
Performance of a histidine-rich protein 2 rapid diagnostic test, paracheck pf ® , for detection of malaria infections in Ugandan pregnant women
(The American Society of Tropical Medicine and Hygiene, 2012)Improved laboratory diagnosis is critical to reduce the burden of malaria in pregnancy. Peripheral blood smears appear less sensitive than Plasmodium falciparum histidine-rich protein 2–based rapid diagnostic tests (RDTs) ... -
Electrocardiographic Evidence of Cardiac Disease by Sex and HIV Serostatus in Mbarara, Uganda
(Global heart,, 2020-12) -
Learning from People with HIV: Their Insights are Critical to Our Response to the Intersecting COVID‑19 and HIV Pandemics in Africa
(AIDS and Behavior, 2020-06-30)Nearly 70% of the global population of people with HIV (PWH) live in sub-Saharan Africa, in countries that are likely to be severely impacted by the rising third wave of COVID-19. The first case of COVID-19 in Sub Saharan ... -
Different methodological approaches to the assessment of in vivo efficacy of three artemisinin-based combination antimalarial treatments for the treatment of uncomplicated falciparum malaria in African children
(Malaria journal, 2008-08)Results: Data analysed represented 2926 patients from 17 studies in nine African countries. Three ACTs were studied: artesunate-amodiaquine (AS+AQ, N = 1702), artesunate-sulphadoxinepyrimethamine (AS+SP, N = 706) and ... -
Rate of clearance of infection is independently associated with clinical outcome in HIV-associated cryptococcal meningitis: analysis of a combined cohort of 262 patients
(Clinical infectious diseases: an official publication of the Infectious Diseases Society of America, 2009)Background—Progress in therapy of cryptococcal meningitis has been slow because of the lack of a suitable marker of treatment response. Previously, we demonstrated the statistical power of a novel endpoint, the rate of ... -
Independent Association between Rate of Clearance of Infection and Clinical Outcome of HIV-Associated Cryptococcal Meningitis: Analysis of a Combined Cohort of 262 Patients
(Clinical infectious diseases,, 2009)Background: Progress in therapy for cryptococcal meningitis has been slow because of the lack of a suitable marker of treatment response. Previously, we demonstrated the statistical power of a novel endpoint, the rate of ... -
Prognostic implications of baseline anaemia and changes in haemoglobin concentrations with amphotericin B therapy for cryptococcal meningitis
(HIV medicine, 2017)Objectives Anaemia represents a common toxicity with amphotericin B-based induction therapy in HIVinfected persons with cryptococcal meningitis. We sought to examine the impact of amphotericinrelated anaemia on ...
