Department of Internal Medicine: Recent submissions
Now showing items 41-60 of 258
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Quantifying the burden of cardiovascular diseases among people living with HIV in sub-Saharan Africa: Findings from a modeling study for Uganda
(Journal of Global Health Reports, 2020)Background: The burden of non-communicable diseases (NCDs) is rapidly increasing in low- and middle-income countries, but remains largely unknown among people living with HIV (PLWH) in most sub-Saharan African countries. ... -
Prevalence of elevated liver transaminases and their relationship with alcohol use in people living with HIV on anti-retroviral therapy in Uganda
(PloS one, 2021)Background: Isoniazid preventive therapy (IPT) reduces tuberculosis reactivation and mortality among persons living with HIV (PLWH), yet hepatotoxicity concerns exclude “regular and heavy alcohol drinkers” from IPT. We ... -
Post-traumatic stress disorder among persons with HIV who engage in heavy alcohol consumption in southwestern Uganda
(BMC psychiatry, 2021)Background: We aimed to describe the prevalence of PTSD symptoms and its associated factors in persons living with HIV (PLWH) in Uganda who engage in heavy alcohol use. Methods: We analyzed baseline data from the Drinkers ... -
Patient choice improves self-efficacy and intention to complete tuberculosis preventive therapy in a routine HIV program setting in Uganda
(PLoS One, 2021)A 12-dose weekly regimen of rifapentine plus isoniazid (3HP) is recommended for the prevention of active tuberculosis (TB); however, it is unclear whether 3HP should be provided by directly observed therapy (DOT) or ... -
Late disease stage at presentation to an HIV clinic in the era of free antiretroviral therapy in sub-Saharan Africa
(JAIDS Journal of Acquired Immune Deficiency Syndromes, 2009)Background: Access to free antiretroviral therapy (ART) in sub-Saharan Africa has been steadily increasing, and the success of large-scale ART programs depends on early initiation of HIV care. However, little is known about ... -
Interventions to Increase HIV Testing Uptake in Global Settings
(Current HIV/AIDS Reports, 2022)Purpose of Review: HIV testing is the critical first step to direct people living with HIV (PLWH) to treatment. However, progress is still being made towards the UNAIDS benchmark of 95% of PLWH knowing their status by 2030. ... -
Qualitative Study of Changes in Alcohol Use Among HIV-Infected Adults Entering Care and Treatment for HIV/AIDS in Rural Southwest Ugand
(AIDS and Behavior, 2015)Alcohol has a substantial negative impact on the HIV epidemic in sub-Saharan Africa, particularly in Uganda, where heavy alcohol consumption is common. Using a content analytic approach, this qualitative study characterizes ... -
Retention in Care among HIV-Infected Patients in Resource-Limited Settings: Emerging Insights and New Directions
(Current Hiv/aids Reports, 2010)In resource-limited settings—where a massive scale up of HIV services has occurred in the last 5 years— both understanding the extent of and improving retention in care presents special challenges. First, retention in care ... -
Estimation of mortality among HIV-infected people on antiretroviral treatment in east Africa: a sampling based approach in an observational, multisite, cohort study
(The lancet HIV, 2015)Background: Mortality in HIV-infected people after initiation of antiretroviral treatment (ART) in resource-limited settings is an important measure of the effectiveness and comparative effectiveness of the global public ... -
Digital Health Screening in People With HIV in Uganda to Increase Alcohol Use Reporting: Qualitative Study on the Development and Testing of the Self-administered Digital Screener for Health
(JMIR formative research, 2022)Background: Alcohol consumption is a critical driver of the HIV epidemic worldwide, particularly in sub-Saharan Africa, where unhealthy alcohol use and HIV are prevalent. Brief alcohol interventions are effective in ... -
Diagnosing Kaposi’s Sarcoma (KS) in East Africa: how accurate are clinicians and pathologists?
(Infectious Agents and Cancer, 2012)HIV-associated KS is the most common reported malignancy in sub-Saharan Africa, and appropriate therapy of KS requires accurate diagnosis. In much of the region, however, KS diagnosis is limited to clinical suspicion without ... -
Contraceptive Use and Associated Factors among Women Enrolling into HIV Care in Southwestern Uganda
(Infectious diseases in obstetrics and gynecology, 2012)Background: Preventing unintended pregnancies among women living with HIV is an important component of prevention of mother-to-child HIV transmission (PMTCT), yet few data exist on contraceptive use among women entering ... -
Comparative analyses of published cost effectiveness models highlight critical considerations which are useful to inform development of new models
(Journal of medical economics, 2020)Background: Comparative analyses of published cost effectiveness models provide useful insights into critical issues to inform the development of new cost effectiveness models in the same disease area. Objective: The ... -
Cell Phone Availability and Usage for mHealth and Intervention Delivery to Persons Living With HIV in a Low-Resource Setting: Cross-sectional Study
(JMIR Formative Research, 2022)Background: HIV/AIDS is now a manageable chronic illness owing to effective antiretroviral therapy (ART), which involves routine follow-up care, including regular physical visits to the clinic. In the recent past, and in ... -
Adding Fuel to the Fire: Alcohol’s Effect on the HIV Epidemic in Sub-Saharan Africa
(Current HIV/AIDS Reports, 2011)Alcohol consumption adds fuel to the HIV epidemic in sub-Saharan Africa (SSA). SSA has the highest prevalence of HIV infection and heavy episodic drinking in the world. Alcohol consumption is associated with behaviors such ... -
Tracking a sample of patients lost to follow-up has a major impact on understanding determinants of survival in HIV-infected patients on antiretroviral therapy in Africa
(Tropical Medicine & International Health, 2010)Objective: To date, data regarding the determinants of mortality in HIV-infected patients starting antiretroviral therapy (ART) in Africa have been primarily derived from routine clinical care settings practicing the public ... -
Feasibility and acceptability of using the novel urine-based FujiLAM test to detect tuberculosis: A multi-country mixed-methods study
(Journal of Clinical Tuberculosis and Other Mycobacterial Diseases, 2022)Background: The novel urine-based FujiLAM test identifies tuberculosis in HIV-positive patients but may be challenging to use at point-of-care (POC). Objectives: We assessed the feasibility and acceptability of using the ... -
Association between biomarkers of inflammation and dyslipidemia in drug resistant tuberculosis in Uganda
(Lipids in Health and Disease, 2024)Background: Active tuberculosis (TB) significantly increases the risk of cardiovascular disease, but the underlying mechanisms remain unclear. This study aimed to investigate the association between inflammation biomarkers ... -
Evaluating the efficacy and safety of tumor treating fields versus laser interstitial thermal therapy in glioblastoma treatment: a comprehensive systematic review and meta-analysis
(Journal of Surgical Protocols and Research Methodologies,, 2023)Tumor Treating Field (TTF) is considered a new treatment option for glioblastoma. Studies in newly diagnosed GBM (ndGBM) patients have demonstrated a good safety profile and improved efficacy. On the other hand, Laser ... -
Comparing the efficacy of endoscopic endonasal versus microscopic transsphenoidal approach for the management of sellar and suprasellar tumors: a systematic review and meta-analysis protoco
(Journal of Surgical Protocols and Research Methodologies, 2023)Managing sellar and suprasellar tumors is challenging due to their diverse origins and proximity to critical structures. The transsphenoidal surgical approach has become the preferred method, evolving from transcranial ...
