Research Articles: Recent submissions
Now showing items 21-40 of 40
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In-Vivo and In-silico Studies Revealed the Molecular Mechanisms of Colocasia esculenta Phenolics as Novel Chemotherapy against Benign Prostatic Hyperplasia via inhibition of 5α‒Reductase and α1-Adrenoceptor.
(Research Square, 2023)Benign Prostatic Hyperplasia (BPH) is a major cause of lower urinary tract infections and erectile dysfunction thus a major contributor to lowering the quality of life among older men. In this study, we investigated the ... -
Effect of Spice form and Extraction Period on Total Phenolic Content of Selected Ugandan Spices
(European Journal of Medicinal Plants, 2022-04-08)Introduction: Spice consumption is one of the globally recognized healthy nutritional practices. Most spices contain phenolic compounds that may prevent or prolong the onset of noncommunicable diseases. The harvesting, ... -
Protocol Optimization for in vitro Micro Propagation of Dioscorea bulbifera Linn. Germplasm
(Journal of Plant Sciences and Crop Protection, 2020-12-23)Dioscorea bulbifera is a wild, underutilized yam species of nutritional and medicinal importance. It is known to treat ulcers, sores, wounds, spasms, dysentery, diabetes, and cancer and its bioactive component known as ... -
Safety profile of Colocasia esculenta tuber extracts in benign prostate hyperplasia
(Research square, 2022)Introduction: This study was motivated by the increasing global incidence of benign prostatic hyperplasia (BPH) and the promising potential of nutraceuticals as complementary therapies in ameliorating its burden. We report ... -
Qualité sanitaire du lait cru tout au long de la filière dans le district de Mbarara et la ville de Kampala en Ouganda
(Revue d’élevage et de médecine vétérinaire des pays tropicaux, 2005)La qualité sanitaire du lait cru est une problématique importante en Ouganda, tant pour des raisons socio-économiques que sanitaires. L’étude conduite sur la filière informelle du lait cru en Ouganda a mis en évidence deux ... -
Prospect into therapeutic potentials of Moringa oleifera phytocompounds against cancer upsurge: de novo synthesis of test compounds, molecular docking, and ADMET studies
(Bulletin of the National Research Centre, 2021)Background: Cancer chemotherapy is difficult because current medications for the treatment of cancer have been linked to a slew of side effects; as a result, researchers are tasked with developing greener cancer chemotherapies. ... -
Prevalence, Correlates and Treatment Needs of Dental Caries Among People on Antiretroviral Therapy in Uganda: A Cross Sectional Study
(Research square, 2022)Background: Oral diseases are estimated to affect half of people living with HIV in the global north, and are often marked by pain, discomfort, disfigurement and reduced quality of life. Both HIV-specific and antiretroviral ... -
Liquid biopsy: Exosomal microRNAs as novel diagnostic and prognostic biomarkers in cancer
(Molecular Cancer, 2022)Background: Detecting cancer at an early stage before clinical manifestation could be an effective strategy to decrease cancer mortality. Thus, identifying liquid biopsy biomarkers with high efficacy could be a promising ... -
In vitro antimycobacterial activity of medicinal plants Lantana camara, Cryptolepis sanguinolenta, and Zanthoxylum leprieurii
(Journal of Clinical Tuberculosis and Other Mycobacterial Diseases, 2022)Background: Imperative need exists to search for new anti-TB drugs that are safer, and more effective against drug-resistant strains. Medicinal plants have been the source of active ingredients for drug development. However, ... -
Effects of season and agro-ecological zone on the microbial quality of raw milk along the various levels of the value chain in Uganda
(Tropical Animal Health and Production, 2008-11-19)Dairy production in Uganda is pasture based and traditional Ankole cattle make up 80% of the cattle herd, reared in both pastoral and agropastoral ecological zones. Regardless of the zone, milk quality is lowest in production ... -
Cucumeropsis mannii seed oil (CMSO) ameliorates adipokines dysfunction and dyslipidemia in male Wistar rats exposed to Bisphenol-A
(BioRxiv, 2022)Bisphenol-A (BPA) and its analog are extensively utilized in the production of plastics which are rather ubiquitous in our environment. At high temperatures, BPA is leached into water and food packed in plastic containers. ... -
CRISPR/Cas9 and next generation sequencing in the personalized treatment of Cancer
(Molecular Cancer, 2022)Background: Cancer is caused by a combination of genetic and epigenetic abnormalities. Current cancer therapies are limited due to the complexity of their mechanism, underlining the need for alternative therapeutic approaches. ... -
Coping strategies for HIV and mental illness comorbidities among adult patients in southwestern Uganda
(Research square, 2022)Background: HIV and mental illness comorbidity remain one of the healthcare challenges with limited information and medical care attention. The co-existence of the two, result in poor coping thereby increasing vulnerability ... -
Induction of Rhizopus oryzae Germination Under Starvation Using Host Metabolites Increases Spore Susceptibility to Heat Stress
(Phytopathology, 2014)Sweetpotato is a nutritional source worldwide. Soft rot caused by Rhizopus spp. is a major limiting factor in the storage of produce, rendering it potentially unsafe for human consumption. In this study, Rhizopus oryzae ... -
Noma as a complication of false teeth (Ebiino) extraction
(Tungotyo Journal of Medical Case Reports, 2017-04-17)Background: Ebiino, also known as false tooth extraction, is a traditional practice done mainly in the remote areas of African countries, including Uganda. It involves the extraction of tooth buds in babies with common ... -
Dynamics of Plasmodium falciparum alleles in children with normal haemoglobin and with sickle cell trait in western Uganda
(El s e v i e r, 2008-07-31)We describe the diversity of Plasmodium falciparum populations in western Uganda and assess the role that asymptomatic malaria carriers with sickle cell trait (HbAS) may be playing on the Plasmodium population structure. ... -
Cost-effectiveness of malaria microscopy and rapid diagnostic tests versus presumptive diagnosis: implications for malaria control in Uganda
(BioMed Central Ltd, 2011)Current Uganda National Malaria treatment guidelines recommend parasitological confirmation either by microscopy or rapid diagnostic test (RDT) before treatment with artemether-lumefantrine (AL). However, the cost-effectiveness ... -
Antibiotic use among patients with febrile illness in a low malaria endemicity setting in Uganda.
(BioMed Central Ltd, 2011)Uganda embraced the World Health Organization guidelines that recommend a universal ‘test and treat’ strategy for malaria, mainly by use of rapid diagnostic test (RDT) and microscopy. However, little is known how increased ... -
Social norms, misperceptions, and mosquito net use: a population-based, cross-sectional study in rural Uganda
(BMC, 2019)Mosquito net use is an essential part of malaria prevention. Although previous research has shown that many people sleep under a mosquito net in endemic areas, it is unknown whether people underestimate how common it is ... -
Malaria morbidity and mortality in Uganda
(Uganda Ministry of Health, 2003-03-30)