Research Articles: Recent submissions
Now showing items 261-280 of 440
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Xpert MTB/RIF Ultra for the diagnosis of HIV-associated tuberculous meningitis: a prospective validation study
(The Lancet infectious diseases, 2020)Introduction: Tuberculous meningitis accounts for 1–5% of tuberculosis cases. Diagnostic delay contributes to poor outcomes. We evaluated the performance of the new Xpert MTB/RIF Ultra (Xpert Ultra) for tuberculous meningitis ... -
Determinants of loss to follow-up among HIV positive patients receiving antiretroviral therapy in a test and treat setting: A retrospective cohort study in Masaka, Uganda
(PLOS ONE, 2020-04-07)Background: Retaining patients starting antiretroviral therapy (ART) and ensuring good adherence remain cornerstone of long-term viral suppression. In this era of test and treat (T&T) policy, ensuring that patients starting ... -
Health-profession students’ teaching and learning expectations in Ugandan medical schools: pre- and postcommunity placement comparison
(Advances in Medical Education and Practice, 2015)Purpose: The benefits of community-based medical education for both students and teachers are becoming increasingly clear. However, there is paucity of information about the importance of incorporating students’ thoughts ... -
Patient experiences and perspectives on Hypertension at a major referral hospital in rural southwestern Uganda
(2020)Objectives Novel care models are needed to address the large burden of hypertension globally. We aimed to explore how patients in rural Uganda experience and perceive hypertension in order to understand factors that ... -
Detection of Mycobacterium Tuberculosis Multiple Strains in Sputum Samples from Patients with Pulmonary Tuberculosis in South Western Uganda using MIRU-VNTR
(Research Square, 2021-09-09)Infections with multiple strains of Mycobacterium tuberculosis are now widely recognized as a common occurrence. Identification of patients infected with multiple strains, provides both insight into the disease dynamics ... -
Five-year retention of volunteer community health workers in rural Uganda: a population-based retrospective cohort
(Health Policy and Planning., 2021)Community health workers (CHWs) effectively improve maternal, newborn and child health (MNCH) outcomes in low-to-middle-income countries. However, CHW retention remains a challenge. This retrospective registry analysis ... -
Use of Colorimetric Culture Methods for Detection of Mycobacterium tuberculosis Complex Isolates from Sputum Samples in Resource- Limited Settings
(Journal of clinical microbiology, 2013-05-08)Despite recent advances, tuberculosis (TB) diagnosis remains imperfect in resource-limited settings due to its complexity and costs, poor sensitivity of available tests, or long times to reporting. We present a report on ... -
Depressive Symptoms Before and After Antiretroviral Therapy Initiation Among Older‑Aged Individuals in Rural Uganda
(AIDS and Behavior, 2019)This study aims to characterize associations between depression symptom severity and HIV infection, both prior to and in years after ART initiation, among older adults. The Ugandan Non-Communicable Diseases & Aging Cohort ... -
Depression in Ugandan Rural Women Involved in a Money Saving Group: The Role of Spouse’s Unemployment, Extramarital Relationship, and Substance Use
(International Journal of Women’s Health, 2021-09-22)Background: Rural women are highly prevalent to depression, where spouse-related factors, including extramarital affairs and poverty, intensify its likelihood of occurrence. However, women engaged with a Money-Saving Group ... -
Training leads to improved performance of Health Unit Management Committees in southwestern Uganda
(Research square, 2020-03-11)Background: A quality health workforce is critical for the development of health systems and effective delivery of health services. In southwestern Uganda, Health Unit Management Committees (HUMCs) are central to the ... -
Depression During Pregnancy and the Postpartum Among HIV-Infected Women on Antiretroviral Therapy in Uganda
(Journal of acquired immune deficiency syndromes (1999), 67(Suppl 4), S179., 2014-12)Background: Among HIV-infected women, perinatal depression compromises clinical, maternal, and child health outcomes. Antiretroviral therapy (ART) is associated with lower depression symptom severity but the uniformity of ... -
Depression and HIV associated neurocognitive disorders among HIV infected adults in rural southwestern Uganda: a cross-sectional quantitative study
(BMC Psychiatry, 2021-07)Background: HIV-Associated Neurocognitive Disorder (HAND remains a pronounced consequence of HIV/AIDS despite improved life expectancies. This is often associated with several dysfunctions such as decrease of attention, ... -
Timing of malaria in pregnancy and impact on infant growth and morbidity: a cohort study in Uganda
(Malaria journal, 2016)Background: Malaria in pregnancy (MiP) is a major cause of fetal growth restriction and low birth weight in endemic areas of sub-Saharan Africa. Understanding of the impact of MiP on infant growth and infant risk of malaria ... -
Ideal Cardiovascular Health and Carotid Atherosclerosis in a Mixed Cohort of HIV-Infected and Uninfected Ugandans
(AIDS Research and Human Retroviruses, 2016)Background and Aims: Preventable cardiovascular disease (CVD) risk factors are responsible for the majority of CVD-related deaths, and are increasingly recognized as a cause of morbidity and mortality for HIV-infected ... -
D-dimer levels and traditional risk factors are associated with incident hypertension among HIV-infected individuals initiating antiretroviral therapy in Uganda
(Journal of acquired immune deficiency syndromes, 2016)Objectives-We sought to describe blood pressure changes after antiretroviral therapy (ART) initiation and evaluate the association of markers of inflammation with incident hypertension in a cohort of HIV-individuals in ... -
Cytomegalovirus Viremia Associated With Increased Mortality in Cryptococcal Meningitis in Sub-Saharan Africa
(Clinical Infectious Diseases, 2019-09)Background. Cryptococcal meningitis and tuberculosis are both important causes of death in persons with advanced human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS). Cytomegalovirus (CMV) viremia ... -
The Prevalence of Community Acquired Salmonellosis, Associated Factors and Antibiotic Susceptibility Among Out Patients Attending Kagando Hospital, Kasese District, Mid-western, Uganda
(Research square, 2021)Background: Uganda has experienced a number of typhoid fever out breaks, the most recent being in Kampala city in which 1,038 (29%) patients were positive out of 3464 suspected cases. In 2011, typhoid cases (1042) were ... -
The pathway of obstructed labour as perceived by communities in south-western Uganda: a grounded theory study
(Global health action, 2011-12-27)Background: Obstructed labour is still a major cause of maternal and perinatal morbidity and mortality in Uganda, where many women give birth at home alone or assisted by non-skilled birth attendants. Little is known of ... -
COVID-19 pandemic: implementing control measures in Africa using the 'SHEF2' model
(Pan African Medical Journal, 2020-09)The COVID-19 Pandemic in Africa is a severe reminder of the brunt of emerging and re-emerging infectious pathogens and the need for simple, context-oriented, and sustainable health models to combat them when the need arises. ... -
Context matters in understanding the vulnerability of women- perspectives from southwestern Uganda.
(Archives of Public Health., 2021-01)Background: Vulnerability at the individual, family, community or organization level affects access and utilization of health services, and is a key consideration for health equity. Several frameworks have been used to ...