dc.contributor.author | Bebell, Lisa M. | |
dc.contributor.author | Ayebare, Arnold | |
dc.contributor.author | Boum, Yap | |
dc.contributor.author | Siedner, Mark J. | |
dc.contributor.author | Bazira, Joel | |
dc.contributor.author | Schiff, Steven J. | |
dc.contributor.author | Metlay, Joshua P. | |
dc.contributor.author | Bangsberg, David R. | |
dc.contributor.author | Ttendo, Stephen | |
dc.contributor.author | Firth, Paul G. | |
dc.date.accessioned | 2022-02-28T06:59:27Z | |
dc.date.available | 2022-02-28T06:59:27Z | |
dc.date.issued | 2016 | |
dc.identifier.citation | Bebell, L. M., Ayebare, A., Boum, Y., Siedner, M. J., Bazira, J., Schiff, S. J., ... & Firth, P. G. (2017). Prevalence and correlates of MRSA and MSSA nasal carriage at a Ugandan regional referral hospital. Journal of Antimicrobial Chemotherapy, 72(3), 888-892. | en_US |
dc.identifier.uri | http://ir.must.ac.ug/xmlui/handle/123456789/1589 | |
dc.description.abstract | Background: Despite increasing antimicrobial resistance globally, data are lacking on prevalence and factors associated with Staphylococcus aureus (SA) and MRSA carriage in resource-limited settings.
Objectives: To determine the prevalence of SA and MRSA nasal carriage and factors associated with carriage among Ugandan regional referral hospital patients.
Methods: We enrolled a cross-section of 500 adults, sampling anterior nares for SA and MRSA carriage using Cepheid Xpert SA Nasal Complete.
Results: Mean age was 37 years; 321 (64%) were female and 166 (33%) were HIV infected. Overall, 316 (63%) reported risk factors for invasive SA infection; 368 (74%) reported current antibiotic use. SA was detected in 29% and MRSA in 2.8%. MRSA and MSSA carriers were less likely than SA non-carriers to be female (50% and 56% ver sus 68%, P ¼ 0.03) or to have recently used b-lactam antibiotics (43% and 65% versus 73%, P ¼ 0.01). MRSA carriers were more likely to have open wounds than MSSA carriers and SA non-carriers (71% versus 27% and 40%,
P ¼ 0.001) and contact with pigs (21% versus 2% and 6%, P ¼ 0.008). MRSA carriage ranged from 0% of HIV clinic participants to 8% of inpatient surgical ward participants (P ¼ 0.01). In multi variable logistic regression analysis, male sex was independently associated with SA carriage (OR 1.68, 95% CI 1.12–2.53, P ¼ 0.01) and recent b-lac tam antibiotic use was associated with reduced odds of SA carriage (OR 0.61, 95% CI 0.38–0.97, P ¼ 0.04).
Conclusions: MRSA nasal carriage prevalence was low and associated with pig contact, open wounds and surgical ward admission, but not with HIV infection | en_US |
dc.description.sponsorship | National Institutes of Health Research | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | Oxford University Press | en_US |
dc.title | Prevalence and correlates of MRSA and MSSA nasal carriage at a Ugandan regional referral hospital | en_US |
dc.type | Article | en_US |