dc.contributor.author | Haberer, Jessica E. | |
dc.contributor.author | Musiimenta, Angella | |
dc.contributor.author | Atukunda, Esther Cathyln | |
dc.contributor.author | Musinguzi, Nicholas | |
dc.contributor.author | Wyatt, Monique A | |
dc.contributor.author | Ware, Norma C | |
dc.contributor.author | Bangsberg, David R | |
dc.date.accessioned | 2022-04-21T14:28:28Z | |
dc.date.available | 2022-04-21T14:28:28Z | |
dc.date.issued | 2016 | |
dc.identifier.citation | Haberer, J. E., Musiimenta, A., Atukunda, E. C., Musinguzi, N., Wyatt, M. A., Ware, N. C., & Bangsberg, D. R. (2016). Short message service (SMS) reminders and real-time adherence monitoring improve antiretroviral therapy adherence in rural Uganda. AIDS (London, England), 30(8), 1295. | en_US |
dc.identifier.isbn | 0269-9370 | |
dc.identifier.uri | http://ir.must.ac.ug/xmlui/handle/123456789/1791 | |
dc.description | Adherence monitoring improve antiretroviral therapy adherence in rural Uganda. | en_US |
dc.description.abstract | Objective: To explore the effects of four types of short message service (SMS) plus real time adherence monitoring on antiretroviral therapy (ART) adherence: daily reminders, weekly reminders, reminders triggered after a late or missed dose (delivered to patients), and notifications triggered by sustained adherence lapses (delivered to patient-nominated social supporters).
Design: Pilot randomized controlled trial.
Methods: Sixty-three individuals initiating ART received a real-time adherence monitor and were randomized (1 : 1 : 1): (1) Scheduled SMS reminders (daily for 1 month, weekly for 2 months), then SMS reminders triggered by a late or missed dose (no monitoring signal within 2 h of expected dosing); SMS notifications to social supporters for sustained adherence lapses (no monitoring signal for >48 h) added after 3 months. (2) Triggered SMS reminders starting at enrolment; SMS notifications to social supporters added after 3 months. (3) Control: No SMS. HIV RNA was determined at 9 months. Percentage adherence and adherence lapses were compared by linear generalized estimating equations and Poisson regression, respectively.
Results: Median age was 31 years, 65% were women, and median enrollment CD4þ cell count was 322 cells/ml 97% took once daily tenofovir/emtricitabine/efavirenz. Compared to control, adherence was 11.1% higher (P¼0.04) and more than 48-h
lapses were less frequent (IRR 0.6, P¼0.02) in the scheduled SMS arm. Adherence and more than 48-h lapses were similar in the triggered SMS arm and control. No differences in HIV RNA were seen.
Conclusion: Scheduled SMS reminders improved ART in the context of real-time monitoring. Larger studies are needed to determine the impact of triggered reminders and role of social supporters in improving adherence. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Wolters Kluwer Health, Inc. | en_US |
dc.subject | Antiretroviral therapy, real-time adherence monitoring, short message service (SMS) | en_US |
dc.title | Short message service (SMS) reminders and real-time adherence monitoring improve antiretroviral therapy adherence in rural Uganda | en_US |
dc.type | Article | en_US |