dc.contributor.author | Ssedyabane, Frank | |
dc.contributor.author | Randall, Thomas C | |
dc.contributor.author | Tusubira, Deusdedit | |
dc.contributor.author | Castro, Cesar M | |
dc.contributor.author | Najjuma, Josephine Nambi | |
dc.contributor.author | Okeny, Christopher | |
dc.contributor.author | Nuwashaba, Doreen | |
dc.contributor.author | Mudondo, Hope | |
dc.contributor.author | Kajabwangu, Rogers | |
dc.contributor.author | Muhumuza, Joy | |
dc.contributor.author | Namuli, Alexcer | |
dc.contributor.author | Ngonzi, Joseph | |
dc.date.accessioned | 2024-01-10T07:32:39Z | |
dc.date.available | 2024-01-10T07:32:39Z | |
dc.date.issued | 2024 | |
dc.identifier.citation | Ssedyabane, F., Randall, T. C., Tusubira, D., Castro, C. M., Najjuma, J. N., Okeny, C., ... & Ngonzi, J. (2024). Serum Lipids, Insulin-Like Growth Factor Binding Protein-3 and Treatment Outcomes in Women with and without Cervical Lesions in South Western Uganda: A Cohort Study. Pathology and Laboratory Medicine International, 91-105. | en_US |
dc.identifier.uri | http://ir.must.ac.ug/xmlui/handle/123456789/3341 | |
dc.description.abstract | Purpose: There is a documented association between cervical cancer and metabolic syndrome. In this study, we determined the association between lipids, insulin-like growth factor binding protein-3 (IGFBP-3) and treatment outcomes for cervical lesions at Mbarara Regional Referral Hospital (MRRH) in south western Uganda.
Patients and Methods: In this prospective cohort study, we recruited 94 cases and 94 controls at the cervical cancer clinic of MRRH, and followed them for 12 months. Cases were confirmed with cytology and/or histology. With consent, we collected demographic data and measured lipids and IGFBP-3 both at baseline and after 12 months. The lipid profile was measured using a Cobas 6000 Chemistry Analyzer, whereas IGFBP-3 was measured using a MAGLUMI fully automated chemiluminescence immunoassay analyzer. Abnormal values for lipids were defined using WHO recommended cut-offs. IGFBP-3 concentrations were divided into two categories of low concentration (<3.29 µg/mL) and raised concentration (≥3.29 µg/mL). Statistical analyses were conducted in STATA version 17 using logistic regression analysis. A p-value of <0.05 was taken to be statistically significant.
Results: The average (mean ± SD) age of our participants was 38.7±8.2 years for controls and 34.5±7.8 years for cases. The average serum IGFBP-3 concentration was 3.769±1.098 µg/mL among cases with cleared lesions and 3.505±0.979 µg/mL among cases whose lesions persisted. A serum IGFBP-3 concentration of less than 3.291 µg/mL was likely to be associated with clearance of cervical lesions (AOR 1.65, p=0.67), although this was not statistically significant. A serum triglyceride concentration of 35–135 mg/dL was also likely to be associated with clearance of cervical lesions (AOR 2.41, p=0.46), although this was also not statistically significant. Conclusion: Although not statistically significant, reduced serum concentrations of IGFBP-3 and triglyceride may be associated with clearance of cervical lesions. Lipid management may be of benefit in the treatment of cervical lesions | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | Pathology and Laboratory Medicine International | en_US |
dc.subject | Cervical intraepithelial neoplasia | en_US |
dc.subject | Cervical lesions | en_US |
dc.subject | Clearance | en_US |
dc.subject | Persistence | en_US |
dc.subject | IGFBP-3 | en_US |
dc.title | Serum Lipids, Insulin-Like Growth Factor Binding Protein-3 and Treatment Outcomes in Women with and without Cervical Lesions in South Western Uganda: A Cohort Study | en_US |
dc.type | Article | en_US |